Larvicidal Activity of Secondary Plant Metabolites inAedes aegyptiControl: An Overview of the Previous 6 Years

Abstract

Aedes aegypti is the main transmitter of several arboviruses, mainly dengue. It occurs, recently, in more than 100 countries and majority of the world population lives in areas of mosquito incidence, marking its control relevant and necessary. Presently, the main form of vector control is the use of synthetic insecticides; however, its continuous application has led to inefficiency due to resistance development. Based on this fact, the insecticides from natural sources appear as a friendly alternative for man and the environment. This study provides an overview of the larvicidal compounds isolated from plant extracts while controlling A. aegypti, in the previous 6 years (2013-2018), and aims to impart more knowledge regarding the described metabolites and to encourage the search for new bioactive compounds. In addition, the proposals for mechanisms of action and structure-activity relationships that may justify the larvicidal potential are also discussed.

Fractionated Extracts From Gnidia kraussiana (Malvales: Thymeleaceae) as Bioactive Phytochemicals for Effective Management of Callosobruchus maculatus (Coleoptera: Chrysomelidae) in Stored Vigna unguiculata (Fabales: Fabaceae) Seeds

“…Thus, acetone solvent may be more appropriated than methanol for chemical extraction for larvicide development. The larvicidal activities of these chemical groups extracted from different plant families were reported ( de Souza Wiuillda et al 2019 ). Different flavonoids are found to alter molting in insect, causing death; they either act as anti-estrogens or inhibit cytochrome P450 isozyme expression and activity ( Salunke et al 2005 ).…”

Larvicidal Activity of Two Rutaceae Species Against the Vectors of Dengue and Filarial Fever

“…In general, protein is the essential element of the animal body as well as insect structure. Its higher amount in their body indicates larger body mass, which establishes higher reproductive success in insects, improved competitive ability (Warren et al, 2006), and disease vulnerability and stress resistance (Lee et al, 2008;de Souza Wuillda, 2019).…”

Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential

“…In recent years, there has been increased interest in secondary metabolites with potential larvicidal activity in a number of countries around the world [ 258 ]. Dengue fever, yellow fever, dengue hemorrhagic fever, malaria and chikungunya are the most severe diseases transmitted by mosquitoes.…”

“…Dengue fever, yellow fever, dengue hemorrhagic fever, malaria and chikungunya are the most severe diseases transmitted by mosquitoes. Aedes aegypti is one of the mosquito species involved in the transmission of such vector disease outbreaks [ 258 , 259 ]. Larvicidal activity has been documented in extracts of conifer spp.…”

“…The mosquito control technique is determined by the larval stages (egg, larvae, pupae, and adult) of the target. Mosquito control methods include spraying chemical insecticides on adult mosquitoes or destroying mosquito larvae before they grow into adults, either by means of synthetic larvicides or by using botanical extracts as an alternative larvicide [ 258 ]. The use of these synthetic insecticides against mosquitoes creates insecticide resistance as well as multifarious problems, such as environmental pollution and poisonous hazards to human beings [ 261 ].…”