Larvicidal activity of plant extracts by inhibition of detoxification enzymes in Culex pipiens

Al-Solami, Habeeb M.

doi:10.1016/j.jksus.2021.101371

Cited by 12 publications

(4 citation statements)

References 36 publications

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“…Herein, AChE showed different activity patterns, where it was significantly increased in columbamine and β -sitosterol treatments, and decreased in (AC), palmatine, and jatrorrhizine treatments, whereas GST was significantly increased in all tested materials. In similar studies, Al-Solami [ 38 ] found that Lantana camara extract significantly restricted the AChE activity in larvae, as compared to larvae treated with other plant extracts and/or positive control, and successfully reduced the GST levels.…”

Section: Discussionmentioning

confidence: 94%

Mosquitocidal Activity of the Methanolic Extract of Annickia chlorantha and Its Isolated Compounds against Culex pipiens, and Their Impact on the Non-Target Organism Zebrafish, Danio rerio

Selim

Rahman

Mahran

et al. 2022

Insects

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In this study, the crude extract and its isolated compounds from the stem bark of Annickiachlorantha were tested for their larvicidal, developmental, and repellent activity against the mosquito vector, Culex pipiens, besides their toxicity to the non-target aquatic organism, the zebrafish (Danio rerio). The acute larvicidal activity of isolated compounds; namely, palmatine, jatrorrhizine, columbamine, β-sitosterol, and Annickiachlorantha methanolic extract (AC), was observed. Developmentally, the larval duration was significantly prolonged when palmatine and β-sitosterol were applied, whereas the pupal duration was significantly prolonged for almost all treatments except palmatine and jatrorrhizine, where it shortened from those in the control. Acetylcholinesterase (AChE) enzyme showed different activity patterns, where it significantly increased in columbamine and β-sitosterol, and decreased in (AC), palmatine, and jatrorrhizine treatments, whereas glutathione S-transferase (GST) enzyme was significantly increased when AC methanolic extract/isolated compounds were applied, compared to the control. The adult emergence percentages were significantly decreased in all treatments, whereas tested compounds revealed non-significant (p > 0.05) changes in the sex ratio percentages, with a slight female-to-male preference presented in the AC-treated group. Additionally, the tested materials revealed repellence action; interestingly, palmatine and jatrorrhizine recorded higher levels of protection, followed by AC, columbamine, and β-sitosterol for 7 consecutive hours compared to the negative and positive control groups. The non-target assay confirms that the tested materials have very low toxic activity compared to the reported toxicity against mosquito larvae. A docking simulation was employed to better understand the interaction of the isolated compounds with the enzymes, AChE and GST. Additionally, DFT calculations revealed that the reported larvicidal activity may be due to the differing electron distributions among tested compounds. Overall, this study highlights the potential of A. chlorantha extract and its isolated compounds as effective mosquitocidal agents with a very low toxic effect on non-target organisms.

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Section: Discussionmentioning

confidence: 94%

Mosquitocidal Activity of the Methanolic Extract of Annickia chlorantha and Its Isolated Compounds against Culex pipiens, and Their Impact on the Non-Target Organism Zebrafish, Danio rerio

Selim

Rahman

Mahran

et al. 2022

Insects

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“…2,4-Difluorobenzoic acid, 2-nitro-5-fluorophenyl ester or 2,4-DFBA (fluorobenzoic acids) had a strong correlation (r = -0.999, P = 0.033) with aphid colonies at 7 DAI. Fluorobenzoic acid and octadecenoic acid compounds are reported to be important insecticidal compounds in controlling Culex pipiens, mosquito larvae [21]. The compound 2,5-Octadecadiynoic acid, methyl ester (fatty acid), was reported as an antimicrobial found in Ziziphus jujuba [22] and Clerodendrum infortunatum L [23].…”

Section: Resultsmentioning

confidence: 99%

Metabolite profile variation of chili pepper genotypes for resistance to aphids infestation

Daryanto

Syukur

SOBIR

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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The cotton aphids (CA) were reported to reduce chili pepper production in tropical area and transmits several viruses. Using resistant cultivars can reduce the number of insecticide sprays and maintain natural enemies. The research objective was to evaluate aphid infestation in seven chili pepper genotypes and investigate secondary metabolite profiles under aphid infestation. Seven chili pepper genotypes belonging to the species Capsicum annuum L. were used in this study. The experiment was conducted using a four-replication randomized complete block design. We used a no-choice clip cage test to evaluate the chili pepper genotype. The evaluation was carried out under greenhouse conditions. Each plant was infested with one aphid using a wet brush in an insect-proof cage about five weeks after sowing. The resistance level was determined after seven days of infection (7 DAI) by counting the number of aphids. Gas chromatography-mass spectrophotometry (GC-MS) was used to perform untargeted metabolomic studies. The results showed that IPB C20 and IPB C367 genotypes had low aphid infestation, while IPB C313 showed the highest aphid infestation. Untargeted metabolomics using GC-MS detected 16 metabolites in the control plant and 27 in the treatment. Principal component analysis (PCA) (PC1 = 62% and PC2 = 23%) can used to differentiate metabolites among resistant genotypes, susceptible genotypes, and control plants. Chili pepper resistance to aphid infestation was antibiosis with numerous potential metabolite chemicals, such as fluorobenzoic acid, which strongly connected with decreased aphid colonies at 7 DAI. This study will be useful for pest control and will aid in the developing of aphid-resistant cultivars.

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“…pipens (LC 50 = 168 p.p.m. ), followed by those of R. stricta , A. fruticose , and R. chalepensis (LC 50 = 248.7, 374.4, and 539.3, respectively; Al‐Solami, 2021). These studies indicate that extracts from various medicinal plants have good larvicidal activities against Aedes , Anopheles , and Culex mosquitoes.…”

Section: Plant Extractsmentioning

confidence: 99%

Efficacy of plant products in controlling disease vector mosquitoes, a review

Hillary,

Ceasar,

Ignacimuthu

2024

Entomologia Exp Applicata

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Mosquitoes pose a severe threat to the environment as vectors of numerous harmful diseases affecting humans and animals. Mosquitoes transmit pathogens that cause dengue, chikungunya, malaria, zika, yellow fever, Japanese encephalitis, and filariasis. Today's mosquito control strategies heavily rely on the use of chemical insecticides such as N,N‐diethyl‐meta‐toluamide (DEET), N,N‐diethyl mandelic acid amide (DEM), and dimethyl phthalate (DMP). However, the widespread use of chemical insecticides has resulted in pollution, bio‐magnification, and other health and environmental issues. It has also become ineffective because of the mosquitoes' aptitude to develop resistance, emphasizing the urgent need for safe, effective, and long‐lasting strategies. An alternative and promising approach to circumventing these obstacles involves the implementation of insecticides made from natural compounds found in plants. Therefore, the scientific community has shifted its focus towards plant‐based phytochemicals, oils, and extracts, as these are eco‐friendly, safe, and cost‐effective alternatives to conventional chemical insecticides. This review aims to provide details on current advances in plant‐based products (plant compounds, extracts, and essential oils), which are used to control all the life cycle stages (egg, larva, pupa, and adult) of the mosquito genera Aedes, Anopheles, and Culex. Hopefully, this review will pave the way to devise control strategies against these challenging pests.

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Larvicidal activity of plant extracts by inhibition of detoxification enzymes in Culex pipiens

Cited by 12 publications

References 36 publications

Mosquitocidal Activity of the Methanolic Extract of Annickia chlorantha and Its Isolated Compounds against Culex pipiens, and Their Impact on the Non-Target Organism Zebrafish, Danio rerio

Mosquitocidal Activity of the Methanolic Extract of Annickia chlorantha and Its Isolated Compounds against Culex pipiens, and Their Impact on the Non-Target Organism Zebrafish, Danio rerio

Metabolite profile variation of chili pepper genotypes for resistance to aphids infestation

Efficacy of plant products in controlling disease vector mosquitoes, a review

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