Larvicidal activity of Mentha x villosa Hudson essential oil, rotundifolone and derivatives

Lima, Tamires Cardoso; Silva, Tayane Kayne Mariano da; Silva, Fabiana Lima; Barbosa-Filho, José Maria; Marques, Márcia Ortiz Mayo; Santos, Roseli La Corte dos; Cavalcanti, Sócrates Cabral de Holanda; Sousa, Damião Pergentino de

doi:10.1016/j.chemosphere.2013.10.035

Cited by 55 publications

(44 citation statements)

References 42 publications

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“…The extraction of the essential oil from fresh leaves of Mentha x villosa and analysis of the EOMV by GC-MS were performed as previously described by Lima et al, [8] and confirmed the identity of the oil to be tested, in particular its major component rotundifolone (ca. 70%).…”

Section: Extraction Of the Essential Oilmentioning

confidence: 99%

“…[7,8] Its essential oil has several proven biological activities such as antinociceptive, [9] cardiovascular, [10] spasmolytic, [11] schistosomicidal, [12] antimicrobial, [13] and larvicidal. [8] Our previous study showed that the essential oil from Mentha x villosa leaves possesses significant cytotoxic action against human tumour cell lines and antitumour activity on mice transplanted with Sarcoma 180 tumour cells. [14] In the same study, we also demonstrated that the essential oil from M. x villosa possesses low systemic toxicity in mice transplanted with Sarcoma 180.…”

Section: Introductionmentioning

confidence: 99%

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Antitumour effects of the essential oil from Mentha x villosa combined with 5‐fluorouracil in mice

Amaral

Andrade

Dória

et al. 2016

Flavour & Fragrance J

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In the previous study, we demonstrated that the essential oil from the leaves of Mentha x villosa (EOMV) shows antitumour activities. In the present paper, the effects of the combination of 5-fluorouracil (5-FU) with the EOMV were determined in mice transplanted with Sarcoma 180 tumour cells. Hematological and biochemical analyses, as well as morphological analyses of the tumour and the organs (liver, spleen and kidney) were performed in order to evaluate the toxicological aspects. The combination of the EOMV (50 and 100 mg/kg/day) with 5-FU (10 mg/kg/day) led to a higher tumour growth inhibition rate (58.9% and 65.7%, respectively) when compared with 5-FU alone at 10 mg/kg/day (30.2%). The combined use of 5-FU (10 mg/ kg/day) with the EOMV (50 and 100 mg/kg/day) showed similar tumour growth inhibition rate to that of 5-FU alone at the highest dose (25 mg/kg/day) with less severe leukopenia. However, neither the enzymatic activity of transaminases nor the urea and creatinine levels were modified when compared with the 5-FU groups. These findings indicate that the EOMV may enhance the therapeutic effectiveness of chemotherapeutic drugs.

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Section: Extraction Of the Essential Oilmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antitumour effects of the essential oil from Mentha x villosa combined with 5‐fluorouracil in mice

Amaral

Andrade

Dória

et al. 2016

Flavour & Fragrance J

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“…Natural compounds (MF, MpC, and PE) were prepared according to Machado et al (2015) and Lima et al (2014) in the laboratory of Prof. Dr. Damião Pergentino de Sousa, University of Paraíba, João Pessoa, PB, Brazil. Ethanol, D-glucose, potassium dichromate, sodium chloride, and potassium dihydrogen phosphate were purchased from Merck, Darmstadt, Germany.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

In vitroandin vivotoxicological evaluations of methyl ferulate, methylp-coumarate, and pulegone 1,2-epoxide

Raza

Muhammad

Sousa

et al. 2015

Pharmaceutical Biology

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Objectives: The objective of this study is to evaluate the toxicity of methyl ferulate (MF), methyl p-coumarate (MpC), and pulegone 1,2-epoxide (PE) with in vitro and in vivo assays. Materials and methods:The in vitro toxicity of MF, MpC, and PE was assessed at a concentration of 10 mg/ml with the Ames assay using two strains of Salmonella typhimurium TA98 and TA100.Human red blood cells (RBC) were used to determine the hemolytic activity of these compounds. The cytotoxicity of above compounds was determined with brine shrimp lethality bioassay (BSLB) at the concentrations of 0.1-20 mg/ml. While dermal and ocular irritation studies were conducted on healthy rabbits (n ¼ 8) for 96 and 12 h post-topical application of test compounds, respectively.Results: PE produced 6-8% hemolysis of RBCs at all the tested concentrations while MF and MpC produced 10-5% hemolysis up to 20 mg/ml, and 50-85% hemolysis at concentrations of 40 and 80 mg/ml, respectively. The Ames assay indicated that MF, MpC, and PE were nonmutagenic as the test values were not significantly higher as compared with background values of the assay. BSLB suggested the lethal concentration (LC 50 ) values of MF, MpC, and PE as 4.38, 6.74, and 25.91 mg/ml, respectively. In vivo ocular and dermal irritation scores of MF, MpC, and PE were comparable with ethanol (control) in rabbits indicating the non-irritant nature of these natural compounds. Conclusion:The present studies suggest that these compounds are non-toxic/non-irritant and might be used for medicinal purposes.

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“…Los reportes demuestran que la presencia de un grupo carbonilo exocíclico y el doble enlace conjugado parecen contribuir a la actividad larvicida (69). En general, la sustitución del doble enlace por un grupo epóxido disminuye la actividad (69,123).…”

Section: Relación Entre Estructura Y Actividad Y Entre Propiedad Y Acunclassified

Essential oils and their components as an alternative in the control of mosquito vectors of disease

et al. 2017

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: diseño del trabajo, revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Benjamín Nogueda-Torres: diseño del trabajo, revisión sistemática de la actividad de los componentes Alejandro D. Camacho: revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Guadalupe Virginia Nevárez-Moorillón: revisión sistematica de la actividad biológica de los aceites esenciales, revisión de los estudios de simulación computacional y modelado molecular de los sesquiterpenos y dianas biológicas, y revisión del manuscrito Luvia E. Sánchez-Torres: revisión sistemática de la actividad de los componentes y escritura del manuscrito Sergio Andrade-Ochoa participó en todas las étapas del estudio. Essential oils and their components as an alternative in the control of mosquito vectors of diseaseMore than half of the human population is exposed to mosquito-borne infections. Climate change and the emergence of strains resistant to traditionally used insecticides have motivated the search of new agents for mosquito population control. Essential oils have been effective repellents and larvicidal agents. The aim of this work was to review research studies conducted in recent years on the larvicidal activity of essential oils and their components against Aedes, Anopheles and Culex mosquitoes, as well as the latest reports about their possible mechanism of action. Más de la mitad de la población humana está expuesta a contraer infecciones transmitidas por mosquitos. La falta de tratamientos y vacunas eficaces para muchas de estas enfermedades hace que su control dependa principalmente de la utilización de agentes insecticidas (1). Los individuos que habitan en las áreas tropicales están más expuestos a contraer enfermedades transmitidas por vectores y este riesgo ha aumentado en otras zonas debido a la globalización (2).Culex, Aedes y Anopheles son vectores de diversas enfermedades, como la filariasis, el dengue, la malaria, y otras. Culex quinquefasciatus está presente en vastas regiones tropicales del mundo, es la principal plaga doméstica en muchas áreas urbanas y está implicada en la transmisión de muchos agentes patógenos, entre ellos, el causante de la filariasis linfática. Esta enfermedad está ampliamente distribuida en las zonas tropicales, con alrededor de 120 millones de personas infectadas en todo el mundo (3).

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Larvicidal activity of Mentha x villosa Hudson essential oil, rotundifolone and derivatives

Cited by 55 publications

References 42 publications

Antitumour effects of the essential oil from Mentha x villosa combined with 5‐fluorouracil in mice

Antitumour effects of the essential oil from Mentha x villosa combined with 5‐fluorouracil in mice

In vitroandin vivotoxicological evaluations of methyl ferulate, methylp-coumarate, and pulegone 1,2-epoxide

Essential oils and their components as an alternative in the control of mosquito vectors of disease

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