Larvicidal Activity of Grandisin Against Aedes aegypti

Maleck, Marise; Alencar, Jerônimo; Guimarães, Anthony Érico; Kato, Massuo Jorge

doi:10.2987/08-5828.1

Cited by 34 publications

(32 citation statements)

References 22 publications

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“…The bioassays were carried out using eggs that were placed in a receptacle containing mineral water with fish food (0.3 mg/larva) (Alcon Guppy) for hatching [9,25]. All experiments were carried out on third instar (L3) larvae (F1-F5) in triplicate with three repetitions, to determine the effect of the neolignan.…”

Section: Methodsmentioning

confidence: 99%

Burchellin: study of bioactivity against Aedes aegypti

et al. 2014

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BackgroundThe dengue mosquito Aedes aegypti Linnaeus, 1762 is a widespread insect pest of serious medical importance. Since no effective vaccine is available for treating dengue, the eradication or control of the main mosquito vector is regarded as essential. Since conventional insecticides have limited success, plants may be an alternative source of larvicidal agents, since they contain a rich source of bioactive chemicals. The aim of this study was to evaluate the larvicidal activity of the neolignan burchellin isolated from Ocotea cymbarum (Lauraceae), a plant from the Amazon region, against third instar larvae of A. aegypti.MethodsBurchellin obtained from O. cymbarum was analyzed. The inhibitory activity against A. aegypti eggs and larvae and histological changes in the digestive system of treated L3 larvae were evaluated. In addition, nitric oxide synthase activity and nitric oxide levels were determined, and cytotoxicity bioassays performed.ResultsThe data showed that burchellin interfered with the development cycle of the mosquito, where its strongest toxic effect was 100% mortality in larvae (L3) at concentrations ≥ 30 ppm. This compound did not show target cell toxicity in peritoneal macrophages from BALB/c mice, and proved to have molecular stability when dissolved in water. The L3 and L4 larvae treated with the compound showed cellular destruction and disorganization, cell spacing, and vacuolization of epithelial cells in small regions of the midgut.ConclusionThe neolignan burchellin proved to be a strong candidate for a natural, safe and stable phytolarvicidal to be used in population control of A. aegypti.

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Section: Methodsmentioning

confidence: 99%

Burchellin: study of bioactivity against Aedes aegypti

et al. 2014

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“…The treatment on A. aegypti consisted of applications of the substance at fi nal concentrations of 10 and 50 g/mL, in glass containers (4.0 cm diameter ´ 4.5 cm high) containing dechlorinated water (10 mL). [23] After 1 hour of treatment, the medium was added to a diet of fi sh meal (Alcon Guppy) at 0.3 mg/larvae, for the mosquitoes to develop. [24] Ten third-stage (L3) larvae were used per group: test, control (without khellin or solvent), and testimony control (solvent containing the dilution of the substance).…”

Section: A Aegypti (Diptera: Culicidae)mentioning

confidence: 99%

Khellin: A furanochromone with toxicity against Oncopeltus fasciatus (Hemiptera) and Aedes aegypti (Diptera)

Maleck¹,

Serdeiro²,

Santos³

et al. 2013

J Nat Pharm

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Natural products isolated from plants may be an alternative source of larvicidal and insecticide activity. Khellin is a natural furanochromone isolated from fruits of Ammi visnaga (L.) Lam. (Umbelliferae family), which grows extensively in the Mediterranean region. This substance shows several types of biological activity, such as in vitro cytotoxicity, antispasmodic action, and phototherapeutic potential. Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti; the milkweed bug, Oncopeltus fasciatus, is a phytophagous Hemiptera and a Phytomonas vector. Our main goal was to evaluate the toxicity of khellin in relation to the nymphs of O. fasciatus (Hemiptera) and larvae of A. aegypti (Diptera). To the best of our knowledge, this is the fi rst report concerning furanochromone bioactivity against insect vectors for human disease.

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“…The inhibition of tubulin polymerization was the only previous report concerning potential antitumor activity of dihydrobenzofuran neolignans related to 3,4-di-O-methylcedrusin. 22 The lignoids isolated from Licaria chrysophylla and Licaria aurea may be important leads for the development of new therapeutic agents based on structural modifications of these compounds. 25 The exploration of the chemical diversity of the naturally occurring lignans and neolignans has resulted in the characterization of many interesting lead compounds in various therapeutic areas; it is thus reasonable to expect that many more leads have yet to be discovered and developed, mainly for antitumor drugs.…”

Section: Resultsmentioning

confidence: 99%

“…One benzofuranoid-type lignan (1) and six neolignans (2-7) were isolated from Licaria chrysophylla [18][19][20][21] while the tetrahydrofuran-type neolignan grandisin (8) was isolated from Licaria aurea (Figure 1). 21 Grandisin was evaluated for larvicidal activity against the mosquito Aedes aegypti 22 and for insect control against Chrysomya megacephala.…”

Section: Introductionmentioning

confidence: 99%

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Bezerra¹,

Lins²,

Athayde-Filho³

et al. 2012

Quím. Nova

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Recebido em 18/5/12; aceito em 28/9/12; publicado na web em 9/11/12Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 μM, while none showed activity between 5 and 70 μM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors.

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Larvicidal Activity of Grandisin Against Aedes aegypti

Cited by 34 publications

References 22 publications

Burchellin: study of bioactivity against Aedes aegypti

Burchellin: study of bioactivity against Aedes aegypti

Khellin: A furanochromone with toxicity against Oncopeltus fasciatus (Hemiptera) and Aedes aegypti (Diptera)

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

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Larvicidal Activity of Grandisin Against Aedes aegypti

Cited by 34 publications

References 22 publications

Burchellin: study of bioactivity against Aedes aegypti

Burchellin: study of bioactivity against Aedes aegypti

Khellin: A furanochromone with toxicity against Oncopeltus fasciatus (Hemiptera) and Aedes aegypti (Diptera)

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-&#945; inhibitory activity

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Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity