Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles

Pinto, Eduardo Júnior Serrão; Araújo, Jennifer Thayanne Cavalcante de; Ferreira, Ricardo Marcelo dos Anjos; Souto, Raimundo Nonato Picanço; Lima, Laís Aragão; Silva, Paulo Goberlânio de Barros; Garcı́a, M. Teresa; Fuente, Ana de la; Sousa, Francisco Fábio Oliveira de

doi:10.1016/j.jddst.2021.102513

Cited by 6 publications

(7 citation statements)

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“…This allowed assessing the effects of the nanoparticles on the environment and health, reproductive system, development, or behavior alterations. 297,299,311,315,318 Together, these results may validate the idea that the choice of a suitable animal model should be conducted based on the nanomedicine's intended application, as referred to formerly in the fit-bydesign approach. For instance, if the nanomedicine is intended for theranostic or only therapeutic purposes, it should be tested on animal models that mimic the diseases.…”

Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 54%

“…These may lead to considerable problems in results’ translation regarding sex and age bias. The majority of the mentioned studies have focused on assessing the toxicity of the nanoparticles with the future intention to use them for nanomedicine purposes, namely to treat cancer or infections. , The animals are usually divided into healthy animals and treatment groups. When the intended purpose of the nanomedicine is addressed for cancer, a group of animals representing the cancer xenograft model that does not receive the treatment regimen, usually termed the control group, is used.…”

Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 99%

“…Interestingly, as referred to previously, inorganic nanoparticles coated with polymers, namely PEG, have reduced associated toxicities and increased half-systemic-circulation time. , The nanoparticles’ toxicity was evaluated using nonmammalian models (20%), such as Daphnia magna , Danio rerio , Drosophila , and Caenorhabditis elegans . This allowed assessing the effects of the nanoparticles on the environment and health, reproductive system, development, or behavior alterations. ,,,, …”

Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

et al. 2022

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Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations and technophobic demands must be counterbalanced in parallel. Some of the burning issues today are the following: (1) Where is nano today? (2) How good are the communication and investment networks between academia/research and governments? (3) Is there any spotlight application for nanotechnology? Nanomedicine is a particular arm of nanotechnology within the healthcare landscape, focused on diagnosis, treatment, and monitoring of emerging (such as coronavirus disease 2019, COVID-19) and contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, and cancer) diseases. However, it may only represent the bright side of the coin. In fact, in the recent past, the concept of nanotoxicology has emerged to address the dark shadows of nanomedicine. The nanomedicine field requires more nanotoxicological studies to identify undesirable effects and guarantee safety. Here, we provide an overall perspective on nanomedicine and nanotoxicology as central pieces of the giant puzzle of nanotechnology. First, the impact of nanotechnology on education and research is highlighted, followed by market trends and scientific output tendencies. In the next section, the nanomedicine and nanotoxicology dilemma is addressed through the interplay of in silico, in vitro, and in vivo models with the support of omics and microfluidic approaches. Lastly, a reflection on the regulatory issues and clinical trials is provided. Finally, some conclusions and future perspectives are proposed for a clearer and safer translation of nanomedicines from the bench to the bedside.

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Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 54%

Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 99%

Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

et al. 2022

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“…In recent years, many university research centers and pharmaceutical industries have started to design and develop NDDS for the diagnosis and therapy of NTDs (Long et al, 2015). The recent advances in nanomaterial-based drug delivery systems for the successful treatment of NTDs, particularly leishmaniasis (Gour et al, 2009), chagas disease (Morilla and Romero, 2015), soiltransmitted helminthiasis (Hoekendijk et al, 2016), african trypanosomiasis/sleeping sickness (Stijlemans et al, 2017) and dengue (Silva et al, 2012;Pinto et al, 2021) are mainly highlighted in this study. Finally, we examined potential approaches to improve research and development of economic nano-engineered materials for NTDs to facilitate their translation into clinics and social implementation.…”

Section: Introductionmentioning

confidence: 98%

Nano Based Approach for the Treatment of Neglected Tropical Diseases

Pandian

Panneerselvam

Pavadai

et al. 2021

Front. Nanotechnol.

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Neglected tropical diseases (NTDs) afflict more than one billion peoples in the world’s poorest countries. The World Health Organization (WHO) has recorded seventeen NTDs in its portfolio, mainly caused by bacterial, protozoal, parasitic, and viral infections. Each of the NTDs has its unique challenges on human health such as interventions for control, prevention, diagnosis, and treatment. Research for the development of new drug molecules against NTDs has not been undertaken by pharmaceutical industries due to high investment and low-returns, which results in limited chemotherapeutics in the market. In addition, conventional chemotherapies for the treatment of NTDs are unsatisfactory due to its low efficacy, increased drug resistance, short half-life, potential or harmful fatal toxic side effects, and drug incompetence to reach the site of parasite infection. In this context, active chemotherapies are considered to be re-formulated by overcoming these toxic side effects via a tissue-specific targeted drug delivery system. This review mainly emphasizes the recent developments of nanomaterial-based drug delivery systems for the effective treatment of NTDs especially sleeping sickness, leishmaniasis, chagas disease, soil-transmitted helminthiasis, african trypanosomiasis and dengue. Nanomaterials based drug delivery systems offer enhanced and effective alternative therapy through the re-formulation approach of conventional drugs into site-specific targeted delivery of drugs.

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“…Important biological activities of AA have already been demonstrated, such as activity against larvae and pupae of Aedes aegypti and Culex quinquefasciatus [14], antiplasmodial activity [15], and antioxidant activity [16]. A report demonstrated the antimicrobial effect of AA when used in zein nanoparticles against biofilm‐producing Streptococcus mutans [17].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L.

Lima

Nascimento

Sousa

et al. 2023

Fundamemntal Clinical Pharma

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The rising of diseases caused by multidrug-resistant bacteria has encouraged researchers to explore more antimicrobial substances, as well as chemicals capable of potentiating the action of existing ones against multidrugresistant bacteria. Anacardium occidentale produces a fruit known as cashew nut, filled with a dark, almost black, caustic, and flammable liquid called cashew nutshell liquid (CNSL). The goal of the study was to evaluate the intrinsic antimicrobial activity of the major compounds present in CNSL, called anacardic acids (AA), as well as their possible modulatory action as an adjuvant of Norfloxacin against a Staphylococcus aureus strain overproducing the NorA efflux pump (SA1199B). Microdilution assays were performed to determine the minimum inhibitory concentration (MIC) of AA against different microbial species. Norfloxacin and Ethidium Bromide (EtBr) resistance modulation assays were performed in the presence or absence of AA against SA1199-B. AA showed antimicrobial activity against Gram-positive bacterial strains tested but no activity against Gram-negative bacteria or yeast strains. At subinhibitory concentration, AA reduced the MIC values for Norfloxacin and EtBr against the SA1199-B strain. Furthermore, AA increased the intracellular accumulation of EtBr in this NorA overproducer strain, indicating that AA are NorA inhibitors. Docking analysis showed that AA probably modulates Norfloxacin efflux by spatial impediment at the same binding site of NorA.

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Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles

Cited by 6 publications

References 46 publications

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

Nano Based Approach for the Treatment of Neglected Tropical Diseases

Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L.

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