Larvicidal action of ethanolic extracts from fruit endocarps of Melia azedarach and Azadirachta indica against the dengue mosquito Aedes aegypti

Wandscheer, Carolina Bueno; Duque, Jonny E.; Silva, Mario A.N. da; Fukuyama, Yoshiyasu; Wohlke, Jonathan L.; Adelmann, Juliana; Fontana, José D.

doi:10.1016/j.toxicon.2004.07.009

Cited by 103 publications

(70 citation statements)

References 28 publications

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“…Kamaraj et al [26] reported that the highest larval mortality was found in leaf petroleum ether, flower methanol extracts of [27] . Wandscheer et al [28] reported the naturally occurring insecticides may play a more prominent role in mosquito control programs in the future. Earlier, Georges et al [29] reported that the n-hexane, ethyl acetate, and methanol extracts of Cassia nigricans showed 100% larval mortality against Ochlerotatus triseriatus.…”

Section: Discussionmentioning

confidence: 99%

“…Their results showed that, The percent adult emergence was inversely proportional to the concentration of compounds and directly proportional to the pupal mortality. Among the five different compounds tested for pupicidal activity against selected vector mosquitoes, the patchouli alcohol was found to be most effective for pupicidal activity provided 28 …”

Section: Related Reportsmentioning

confidence: 98%

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Pupicidal and repellent activities of Pogostemon cablin essential oil chemical compounds against medically important human vector mosquitoes

Gokulakrishnan¹,

Elumalai²,

Shanmugam

et al. 2013

Asian Pacific Journal of Tropical Disease

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Section: Discussionmentioning

confidence: 99%

Section: Related Reportsmentioning

confidence: 98%

Pupicidal and repellent activities of Pogostemon cablin essential oil chemical compounds against medically important human vector mosquitoes

Gokulakrishnan¹,

Elumalai²,

Shanmugam

et al. 2013

Asian Pacific Journal of Tropical Disease

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“…General cautions must be taken for the possible presence of aflatoxins, usually present in case of bad storage, as in other botanical raw materials. The results showed that neem products could act primarily as larvicides (Zebitz, 1986(Zebitz, , 1987Naqvi et al, 1991;Rao et al, 1992Rao et al, , 1995Amorose, 1995;Wandscheer et al, 2004;Okumu et al, 2007, Howard et al, 2009. Organic solvent extracts and oils from neem and Melia azedrach have displayed several bioactivities against insects governing chemical maturation of molt hormones, chitin biosynthesis and field deterrence.…”

Section: Using Neem Treementioning

confidence: 99%

Neem Tree (Azadirachta indica A. Juss) as Source of Bioinsectides

Nicoletti

Maccioni²,

Coccioletti³

et al. 2012

Insecticides - Advances in Integrated Pest Management

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Micro vs. macro competing for lifeMicroorganims are difficult to find and to kill, because they are in enormous number and everywhere. For instance, in our body we can count more procariotic than eucariotic cells. Fortunately, most of them are useful friends, but others can be very dangerous and destructives. Actually, microorganisms are liable of major plagues affecting humans. These invisible our competitors act infections by complicated mechanisms, often involving other creatures. Mosquitos are the favorite partners as major vector of transmission. Therefore, mosquitos are co-responsible of malaria, dengue fever, yellow fever, filariasis, schistosomiasis, Japanese encephalitis, Chagas morbus, hemorrhagic fever, arbovirosis, as well as of several minor pathologies, such as systemic allergic and inflammatory reactions and dolorous bites. Although in developed countries the impact of these pathologies is nowadays restricted or absent, and main causes of death are related to physiological aspects (cancer, hearth and www.intechopen.com Insecticides -Advances in Integrated Pest Management 412 coronary failures, ecc.), in the remaining predominant part of the world, the alert is always the same and means infection by injure or by bite. Practically all mankind living in ordinary conditions is continuously exposed to one or more mosquito-borne or connected diseases and suffer in different degrees the effects of the mosquitos attack. Only dengue worldwide threatens the health of around 2.5 billion people, and figures for malaria are surely worst. Malaria infects more than 500 million humans each year. About 90% of cases occur in Africa, including those of malaria-related deaths, but only in India 15 million cases and 20,000 deaths are estimated annually by WHO. However, as all living beings, also microorganisms have their own Achilles heel. Their movement capacity is very limited, therefore they use animals as vectors for efficiently diffusing in every habitats. Usually, they change to adapt to the host, accumulating therein and becoming vulnerable. Therefore, the option seems to be simple: kill the vector and kill the microorganism. Fighting the vectorSeveral strategies have been proposed against microorganism/mosquito based diseases in order to control or at least limit mosquitos invasion, mainly based on three types of action: direct, environmental, indirect. Direct methods use as target the adults, whereas indirect methods are mainly focused on effects on mosquito development, including controls of larvae by hormones or other growth regulators. Environmental methods are based on change in the habitat of the insect and display severe collateral effects on other organisms. So far, mainly synthetic insecticides have been produced and used, in large quantities and types. Initial euphoria for the resolving effects has been punctually followed by negative drawback. Chemical pesticides resulted non-selective, that means harmful and toxic to other organisms including humans, plus the cause of a series of unexpected and dur...

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“…We also described the seed limonoids from Melia azedarach as being toxic to A. aegypti larvae (Wandscheer et al, 2004). More recently, our preliminary toxicity bioassays against Artemia salina nauplii have indicated that simple ethanolic extracts from other species of Brazilian flora may kill A. aegypti larvae with similar efficiency or even better.…”

Section: Introductionmentioning

confidence: 93%

“…St.-Hil., Aquifoliaceae, which is known as "erva-mate", biosynthesizes methylxanthines or puric alkaloids which act as defense mechanism against insects and molds (Ashihara et al, 2008;Cardozo Jr et al, 2007;Jacques et al, 2008). Melia azedarach L., Meliaceae, which is known as the Chinaberry tree, "santa-bárbara" or "cinamomo", produces bitter triterpenoids called limonoids and these compounds inhibit chitin biosynthesis and therefore block the development or renewal of the exoskeleton during the insect morphogenetic cycle (Cronquist, 1988;Kumar et al, 1996;Wandscheer et al, 2004). The species Origanum vulgare L., Lamiaceae, is rich in p-cymene and in the phenolic derivatives carvacrol and thymol, the later ones being toxic to Culex pipiens mosquito larvae (Arcila-Lozano et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

The combined action of phytolarvicides for the control of dengue fever vector, Aedes aegypti

Grzybowski¹,

Tiboni²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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Amongst other botanical sources, Annona muricata L., Annonaceae, seeds and Piper nigrum L., Piperaceae, fruits are particularly enriched with acetogenins and piperine-related amides, respectively. These crude ethanolic extracts are potent bioactives that can kill Aedes aegypti larvae (dengue fever mosquito). A. muricata displayed a 93.48 μg/mL LC50 and P. nigrum an 1.84 μg/mL LC50. An uncommon pharmacognostical/toxicological approach was used, namely different combinations of both extracts to achieve an improved lethal effect on the larvae. The independence test (χ²) was utilized to evaluate the combination of the two crude extracts. All of the tested combinations behaved synergistically and these novel results were attributed to the completely different biochemical mechanisms of the differentiated chemical substances that were present in the two botanical sources. Besides the two above selected plants, Melia azedarach L., Meliaceae, Origanum vulgare L., Lamiaceae, and Ilex paraguariensis A. St.-Hil., Aquifoliaceae, in order of decreasing toxicity, may also be sought as potential extracts for the sake of synergic combinations.

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Larvicidal action of ethanolic extracts from fruit endocarps of Melia azedarach and Azadirachta indica against the dengue mosquito Aedes aegypti

Cited by 103 publications

References 28 publications

Pupicidal and repellent activities of Pogostemon cablin essential oil chemical compounds against medically important human vector mosquitoes

Pupicidal and repellent activities of Pogostemon cablin essential oil chemical compounds against medically important human vector mosquitoes

Neem Tree (Azadirachta indica A. Juss) as Source of Bioinsectides

The combined action of phytolarvicides for the control of dengue fever vector, Aedes aegypti

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