Larval crowding results in hormesis-like effects on longevity in Drosophila: timing of eclosion as a model

Lushchak, Oleh; Karaman, H. S.; Kozeretska, Iryna; Koliada, Alexander; Zabuga, O. G.; Pisaruk, Anatoly; Koshel, N. M.; Mechova, L. V.; Inomistova, M.; Khranovska, N.; Vaiserman, Alexander

doi:10.1007/s10522-018-9786-0

Cited by 25 publications

(39 citation statements)

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“…Moreover, high larval density increases local temperature (Appleby and Credland 2007) and promotes a generalised stress response which can mediate individual's thermotolerance (Henry et al 2018). Given the ongoing environmental changes and the rapid decline in insect species worldwide (Wilson and Maclean 2011), it is appealing that population density could mediate the ability of populations to overcome extreme temperature shocks (Lushchak et al 2019). Similar general effects of larval density are observed in Hymenopterans (Kuno 1962;Milonas 2005;Taylor 1988) although more studies in parasitoids, which poses a more complex relationship between developmental density and resource (e.g., host size), are needed.…”

Section: Immediate and Delayed Density-dependent Effectsmentioning

confidence: 97%

Integrative developmental ecology: a review of density-dependent effects on life-history traits and host-microbe interactions in non-social holometabolous insects

Ponton

Morimoto

2020

Evol Ecol

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Population density modulates a wide range of eco-evolutionary processes including inter- and intra-specific competition, fitness and population dynamics. In holometabolous insects, the larval stage is particularly susceptible to density-dependent effects because the larva is the resource-acquiring stage. Larval density-dependent effects can modulate the expression of life-history traits not only in the larval and adult stages but also downstream for population dynamics and evolution. Better understanding the scope and generality of density-dependent effects on life-history traits of current and future generations can provide useful knowledge for both theory and experiments in developmental ecology. Here, we review the literature on larval density-dependent effects on fitness of non-social holometabolous insects. First, we provide a functional definition of density to navigate the terminology in the literature. We then classify the biological levels upon which larval density-dependent effects can be observed followed by a review of the literature produced over the past decades across major non-social holometabolous groups. Next, we argue that host-microbe interactions are yet an overlooked biological level susceptible to density-dependent effects and propose a conceptual model to explain how density-dependent effects on host-microbe interactions can modulate density-dependent fitness curves. In summary, this review provides an integrative framework of density-dependent effects across biological levels which can be used to guide future research in the field of ecology and evolution.

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Section: Immediate and Delayed Density-dependent Effectsmentioning

confidence: 97%

Integrative developmental ecology: a review of density-dependent effects on life-history traits and host-microbe interactions in non-social holometabolous insects

Ponton

Morimoto

2020

Evol Ecol

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“…Population density, nutrition conditions, and diet supplementations with various active molecules or natural extracts affect fly lifespan and metabolism by triggering mRNA levels of certain peptides. Larval density affected lifespan partially by triggering an expression of the gene encoding the insulin receptor dInR (Lushchak et al, 2019). DILPs are also independently regulated transcriptionally by dietary interventions.…”

Section: Factors Affecting Transcription Of Dilpsmentioning

confidence: 99%

Drosophila insulin‐like peptides: from expression to functions – a review

Semaniuk

Piskovatska

Strilbytska

et al. 2020

Entomologia Exp Applicata

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Insulin‐like peptides (ILPs) belong to the insulin superfamily and act as hormones, neuromediators, and growth factors during the post‐embryonic life‐cycle stages of insects. These peptides are encoded by different genes in various species. In the genus Drosophila, eight peptides are known, seven of which are likely to bind the Drosophila insulin receptor, whereas DILP8 is a known ligand of the Lgr3 receptor. Binding of DILPs 1‐7 to receptors leads to activation of intracellular proteins related to the conserved insulin/IGF (insulin‐like growth factors) signaling pathway. The insulin pathway acts within a complex physiological regulatory network involved in the coordination of development, growth, behavior, metabolism, lifespan, and cognitive functions in insects. The current review summarizes recent data about the structure and function of ILPs in fruit flies. The role of environmental factors and genetic manipulations in modulating the functions of DILPs and their association with lifespan and metabolism of Drosophila are assessed. Further investigation and identification of pharmacological or biotechnological interventions that may decrease insulin/IGF signaling could be a highly promising approach for extension of human health span and longevity.

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“…The pioneering studies of Lints and Lints (1969ab✉ showed that, in females, increasing preimaginal density decreased mean daily fecundity, weight, thoracic size and increased duration of development and lifespan. Preimaginal density also decreased larval viability (Moya and Botella 1985;Zwaan et al 1991✉ or fecundity (Lushchak et al 2019✉. These results have been replicated in both sexes and may probably be explained at least partly by a lack of yeast, as supplementing crowded cultures with yeast decreased some effects of crowding and, conversely, removing yeast -3mimicked the effects of crowding in non-crowded cultures (Klepsatel et al 2018✉.…”

Section: Introductionmentioning

confidence: 66%

Neglecting larval rearing conditions in Drosophila melanogaster can negatively impact research on ageing

Bourg

2021

Biogerontology

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The developmental conditions of Drosophila melanogaster flies can modify the phenotypic traits of adults. However, the control of these conditions is neglected by some authors in their articles and the readers are unaware, for instance, whether flies developed in crowded cultures or fed on a new or used medium. Controlling developmental conditions allows to know precisely the viability of flies, their duration of development and sex-ratio, which can be warning signals of bad rearing conditions. As developmental conditions can modify the results of experiments on the effects of ageing it is necessary to strictly control them.

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Larval crowding results in hormesis-like effects on longevity in Drosophila: timing of eclosion as a model

Cited by 25 publications

References 50 publications

Integrative developmental ecology: a review of density-dependent effects on life-history traits and host-microbe interactions in non-social holometabolous insects

Integrative developmental ecology: a review of density-dependent effects on life-history traits and host-microbe interactions in non-social holometabolous insects

Drosophila insulin‐like peptides: from expression to functions – a review

Neglecting larval rearing conditions in Drosophila melanogaster can negatively impact research on ageing

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