Larval crowding in Drosophila melanogaster induces Hsp70 expression, and leads to increased adult longevity and adult thermal stress resistance

Sørensen, Jesper Givskov; Loeschcke, Volker

doi:10.1016/s0022-1910(01)00119-6

Cited by 163 publications

(132 citation statements)

References 37 publications

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“…Our data provide further points of contrast between dwarf mice, and mice whose longevity reflects either a low-calorie or a methionine-restricted diet: the former show stress resistance in tests of skin cell fibroblasts, and the latter show resistance to APAP toxicity, but not vice versa. Work in worms and flies has suggested that resistance to multiple forms of stress is characteristic of mutants that confer extended life span (Larsen, 1993;Sorensen and Loeschcke, 2001;Arking, 2001;de Castro et al, 2004), leading to the plausible idea that stress resistance itself brings about the retardation of aging and postponement of death, at least in these invertebrate systems. We take, as our working hypothesis, the idea that stress resistance in one or more cell types may play a role in the anti-aging effects of dwarf, CR and Meth-R mice, but acknowledge that much more is still to be learned about the cells and tissues involved in each of these models, the ways in which stress resistance is induced by nutritional and hormonal deviations, and the pathways by which altered cellular properties delay or decelerate age-related injuries in critical tissues.…”

Section: Discussionmentioning

confidence: 99%

Stress resistance and aging: Influence of genes and nutrition

Harper

Salmon

Chang

et al. 2006

Mechanisms of Ageing and Development

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Previous studies have shown that dermal fibroblast cell lines derived from young adult mice of the long-lived Snell dwarf (dw/dw), Ames dwarf (df/df) and growth hormone receptor knockout (GHR-KO) mouse stocks are resistant, in vitro, to the cytotoxic effects of hydrogen peroxide, cadmium, ultraviolet light, paraquat, and heat. Here we show that, in contrast, fibroblasts from mice on low-calorie (CR) or low methionine (Meth-R) diets are not stress resistant in culture, despite the longevity induced by both dietary regimes. A second approach, involving induction of liver cell death in live animals using acetaminophen (APAP), documented hepatotoxin resistance in the CR and Meth-R mice, but dw/dw and GHR-KO mutant mice were not resistant to this agent, and were in fact more susceptible than littermate controls to the toxic effects of APAP. These data thus suggest that while resistance to stress is a common characteristic of experimental life span extension in mice, the cell types showing resistance may differ among the various models of delayed or decelerated aging.

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Section: Discussionmentioning

confidence: 99%

Stress resistance and aging: Influence of genes and nutrition

Harper

Salmon

Chang

et al. 2006

Mechanisms of Ageing and Development

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“…A fruit fly cannot mate until its cuticle has hardened, and our experience indicates that when males are collected within 12h, the vast majority are virgins. Male and female flies have different stress susceptibilities (Sorensen and Loeschcke, 2001), so it is important to note that the results of these experiments might differ if females or mated individuals had been used. Fly bottles were placed inside Plexiglas chambers, each of which were regulated at a test P O2 by a ROXY-8 oxygen regulation system (Sable Systems, Las Vegas, NV, USA).…”

Section: Maintenance Of Flies and Oxygen Rearingmentioning

confidence: 99%

Lifespan and oxidative stress show a non-linear response to atmospheric oxygen inDrosophila

Rascón

Harrison

2010

Journal of Experimental Biology

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SUMMARYOxygen provides the substrate for most ATP production, but also serves as a source of reactive oxygen species (ROS), which can induce cumulative macromolecular oxidative damage and cause aging. Pure oxygen atmospheres (100kPa) are known to strongly reduce invertebrate lifespan and induce aging-related physiological changes. However, the nature of the relationship between atmospheric oxygen, oxidative stress, and lifespan across a range of oxygen levels is poorly known. Developmental responses are likely to play a strong role, as prior research has shown strong effects of rearing oxygen level on growth, size and respiratory system morphology. In this study, we examined (1) the effect of oxygen on adult longevity and (2) the effect of the oxygen concentration experienced by larvae on adult lifespan by rearing Drosophila melanogaster in three oxygen atmospheres throughout larval development (10, 21 and 40kPa), then measuring the lifespan of adults in five oxygen tensions (2, 10, 21, 40, 100kPa). We also assessed the rate of protein carbonyl production for flies kept at 2, 10, 21, 40 and 100kPa as adults (all larvae reared in normoxia). The rearing of juveniles in varying oxygen treatments affected lifespan in a complex manner, and the effect of different oxygen tensions on adult lifespan was non-linear, with reduced longevity and heightened oxidative stress at extreme high and low atmospheric oxygen levels. Moderate hypoxia (10kPa) extended maximum, but not mean lifespan.

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“…Some studies have addressed the effect of density per se on behavioral traits, such as locomotor activity (Sewell 1979, Bahrndorff et al 2012, although only under one set of thermal conditions and for either males or females. In addition, studies have found that larval density in Drosophila can also affect thermal performance, where larvae reared at high densities show increased expression of heat shock proteins and increased thermal performance (Sørensen and Loeschcke 2001).…”

mentioning

confidence: 99%

Temperature and Population Density Effects on Locomotor Activity of <I>Musca domestica</I> (Diptera: Muscidae)

et al. 2013

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The behavior of ectotherm organisms is affected by both abiotic and biotic factors. However, a limited number of studies have investigated the synergistic effects on behavioral traits. This study examined the effect of temperature and density on locomotor activity of Musca domestica (L.). Locomotor activity was measured for both sexes and at four densities (with mixed sexes) during a full light and dark (L:D) cycle at temperatures ranging from 10 to 40ºC. Locomotor activity during daytime increased with temperature at all densities until reaching 30ºC and then decreased. Highdensity treatments significantly reduced the locomotor activity per fly, except at 15ºC. For both sexes, daytime activity also increased with temperature until reaching 30 and 35ºC for males and females, respectively, and thereafter decreased. Furthermore, males showed a significantly higher and more predictable locomotor activity than females. During nighttime, locomotor activity was considerably lower for all treatments. Altogether the results of the current study show that there is a significant interaction of temperature and density on daytime locomotor activity of M. domestica and that houseflies are likely to show significant changes in locomotor activity with change in temperature. BioOne (www.bioone.org) is a nonprofit, online aggregation of core research in the biological, ecological, and environmental sciences. BioOne provides a sustainable online platform for over 170 journals and books published by nonprofit societies, associations, museums, institutions, and presses.Your use of this PDF, the BioOne Web site, and all posted and associated content indicates your acceptance of BioOne's Terms of Use, available at www.bioone.org/page/terms_of_use.Usage of BioOne content is strictly limited to personal, educational, and non-commercial use. Commercial inquiries or rights and permissions requests should be directed to the individual publisher as copyright holder. BEHAVIOR Temperature and Population Density Effects on Locomotor Activity ofMusca domestica (Diptera: Muscidae) ABSTRACT The behavior of ectotherm organisms is affected by both abiotic and biotic factors. However, a limited number of studies have investigated the synergistic effects on behavioral traits. This study examined the effect of temperature and density on locomotor activity of Musca domestica (L.). Locomotor activity was measured for both sexes and at four densities (with mixed sexes) during a full light and dark (L:D) cycle at temperatures ranging from 10 to 40ЊC. Locomotor activity during daytime increased with temperature at all densities until reaching 30ЊC and then decreased. Highdensity treatments signiÞcantly reduced the locomotor activity per ßy, except at 15ЊC. For both sexes, daytime activity also increased with temperature until reaching 30 and 35ЊC for males and females, respectively, and thereafter decreased. Furthermore, males showed a signiÞcantly higher and more predictable locomotor activity than females. During nighttime, locomotor activity ...

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Larval crowding in Drosophila melanogaster induces Hsp70 expression, and leads to increased adult longevity and adult thermal stress resistance

Cited by 163 publications

References 37 publications

Stress resistance and aging: Influence of genes and nutrition

Stress resistance and aging: Influence of genes and nutrition

Lifespan and oxidative stress show a non-linear response to atmospheric oxygen inDrosophila

Temperature and Population Density Effects on Locomotor Activity of <I>Musca domestica</I> (Diptera: Muscidae)

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