LARS-like symptoms in the general population may suggest the significance of postoperative functional problems and emotional implications of rectal surgery

Frunza, Tudor; Luncă, Sorinel; Baciu, Iustina; Axinia, Iulia; Mocanu, C; Crudu, Andreea; Bujor, Narcis; Livenschi, Lucia F; Nicolaiev, Claudiu A; Hulubencu, Andreea; Diaconu, Anca; Valasciu, Emilia; Jalobceastai, Ioana; Tibirna, Malina; Dimofte, Mihail G

doi:10.22543/7674.62.p278285

Cited by 2 publications

(1 citation statement)

References 13 publications

(14 reference statements)

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“…This has been confirmed in a recent study, showing LARS-score increase, not only after low anterior resection, but also after sigmoid resection. (9,10) According to clinical experience as well, LARS can occur after any type of colorectal surgery as we have seen multiple patients suffering from functional bowel complaints even after right sided colectomy.…”

Section: Introductionmentioning

confidence: 99%

Low anterior resection syndrome (LARS) and quality of life after colectomy

Meurs,

Dumoulin,

De Sutter

et al. 2023

Int J Colorectal Dis

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This study was approved by the Ethical Committee of the Antwerp University Hospital and the University of Antwerp. (number B3002020000262) Meurs Juul and Komen Niels are the founders of this study. Meurs Juul, Dumoulin Xavier, De Sutter Nicolas and Smolders Yannick are the main authors, performing data extraction, data analysis and drafting the manuscript. Furthermore, Komen Niels and Van Den Broeck Sylvie contributed to this work by critically revising it and giving their approval for this version to be published .

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Section: Introductionmentioning

confidence: 99%

Low anterior resection syndrome (LARS) and quality of life after colectomy

Meurs,

Dumoulin,

De Sutter

et al. 2023

Int J Colorectal Dis

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Low Anterior Resection Syndrome in a Reference North American Sample: Prevalence and Associated Factors

Moon

Ehlebracht

Cwintal

et al. 2023

Journal of the American College of Surgeons

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Background: Low anterior resection syndrome(LARS) is a well described consequence of rectal cancer treatment. Studying the degreeto which bowel dysfunction exists in the general population may help to better interpret to what extent LARS is related to disease and/or cancer treatment. Currently, North American LARS normative data is lacking. The aim of this study was to describe the prevalence of bowel dysfunction, as measured by the LARS score, and quality of life(QoL) in a reference North American sample. Quality of life was measured and associations between participant characteristics and LARS were identified. Study Design: This was a single-institution cross-sectional study of asymptomatic adults who underwent screening and surveillance colonoscopies from 2018-2021 with no/benign endoscopic findings. Survey was conducted on select comorbidities, sociodemographic factors, LARS, and QoL. Outcomes were LARS and QoL. Multivariable linear regression accounting for a priori clinical factors associated with bowel dysfunction was performed. Results: Of 1,004 subjects approached, 502(50.0%) participated, and 135(26.9%) participants had major/minor LARS. On multiple linear regression, female gender (β=2.15, 95%CI 0.30,4.00), younger age (β=-0.10, 95%CI -0.18,-0.03), Caucasian ethnicity (β=2.45, 95%CI 0.15,4.74), and presence of at least one of the following factors: diabetes, depression, neurological disorder, or cholecystectomy (β=3.54, 95%CI 1.57,5.51) were independently associated with a higher LARS score. Individuals with LARS had lower global QoL, functional subscales and various symptom subscales scores. Conclusions: Our study identified the baseline prevalence of LARS in asymptomatic adults who have not undergone a low anterior resection. This normative data will allow for more accurate interpretation of ongoing studies on LARS in North American rectal cancer patients.

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LARS-like symptoms in the general population may suggest the significance of postoperative functional problems and emotional implications of rectal surgery

Abstract: LARS-like symptoms in the general population may suggest the significance of postoperative functional problems and emotional implications of rectal surgery

Cited by 2 publications

References 13 publications

Low anterior resection syndrome (LARS) and quality of life after colectomy

Low anterior resection syndrome (LARS) and quality of life after colectomy

Low Anterior Resection Syndrome in a Reference North American Sample: Prevalence and Associated Factors

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