Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid

Arteaga, Silvia; Andrade‐Cetto, Adolfo; Cárdenas, René

doi:10.1016/j.jep.2005.02.002

Cited by 209 publications

(195 citation statements)

References 61 publications

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“…ex DC.) Coville (Zygophyllaceae)], which has been used in traditional medicine against at least 50 ailments including kidney stones, diabetes, inflammation, and arthritis (Arteaga et al, 2005). Previous studies also confirmed NDGA as an antifungal against pathogenic fungi (Beggs et al, 1978;Martinez-Tellez et al, 2005) and that it has antioxidant activity in vitro and in vivo (Harper et al, 1999).…”

Section: In Vivo Antioxidant Assaysmentioning

confidence: 97%

Secondary Assays for Testing the Mode of Action of Natural Products with Bioactivity Against Fungi

Smith

Cruz

Golshani

et al. 2008

Pharmaceutical Biology

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Identification of novel antifungals is needed, and plantderived compounds offer important leads in this respect. This article initiates a compendium of secondary assays for testing hypotheses on mode of action of plant-derived compounds. Three assays were developed to evaluate compounds that are hypothesized to effect cell wall function, transcription, and oxidative stress. A hypothesized perturbation on cell wall integrity by chimaphilin and Echinacea root extracts was supported using sonication and heat shock assays. Heat shock treatments reduced the number of viable cells recovered when yeast was grown in the presence of subinhibitory concentrations of chimaphilin. A reduction in cell numbers was also observed with both sonicationbased and heat shock-based assays when yeast was grown in the presence of Echinacea purpurea (L.) Moench (Asteraceae) extracts. The hypothesis that chimaphilin impedes mRNA transcription processes was also supported by a β-galactosidase reporter gene assay. The antioxidant activity of nordihydroguaiaretic acid (NDGA) and ascorbic acid were assessed using a yeast strain that does not grow under hyperoxic conditions. At the concentrations assayed, NDGA did not remediate this sensitivity to hyperoxia, whereas ascorbic acid did. These and additional assays are further reviewed with an aim to collate and standardize secondary assays and streamline antifungal mode of action determinations.

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Section: In Vivo Antioxidant Assaysmentioning

confidence: 97%

Secondary Assays for Testing the Mode of Action of Natural Products with Bioactivity Against Fungi

Smith

Cruz

Golshani

et al. 2008

Pharmaceutical Biology

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“…L. tridentada is a common shrub of North American warm deserts. Its dominance has increased within 19 million ha of lands previously considered desert grasslands in response to disturbances such as grazing (Arteaga et al, 2005). While often viewed as an indicator of desertified conditions and the focus of extensive control efforts it is also an important plant with a long history of medicinal use (Arteaga et al, 2005).…”

Section: Gobernadora (Larrea Tridentata (Dc) Cav)mentioning

confidence: 99%

Mexican Plants Used in the Salmonellosis Treatment

Arrieta-Báez¹,

Esparza²,

Manuel³

2012

Salmonella - A Diversified Superbug

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“…5) Meanwhile, a few studies have been performed on LOX inhibitors originated from algae. 6,7) Recently, we have isolated alkapolyenes and pheophytin a as LOX inhibitors from the brown alga Sargassum thunbergii and the red alga Odonthalia corymbifera, respectively.…”

mentioning

confidence: 99%