Laringitis por rhodococcus equi en paciente con sida

Mateu, Leandro; Serra, Monsoriu; segovia, M.T. Llavero; cuenca, B. Cano; Climent, Francisco Pérez; Vaíllo, F Giménez; alario, E. Grau; Santander, R. Lázaro

doi:10.1016/s0001-6519(02)78376-3

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Of note, when our patient underwent fiberoptic bronchoscopy, a nascent mass was found at the mouth of the middle and lower lobes of the right lung, which was diagnosed as an inflammatory granulomatous hyperplasia on histopathologic biopsy. We hypothesized that the endobronchial mass was associated with R. equi infection, which has been previously reported as an associated endobronchial mass in addition to pulmonary manifestations in HIV patients infected with R. equi [ 10 - 12 ]. To our knowledge, this is the first reported case about a renal transplant recipient who developed pleural empyema combined with endobronchial mass after infection with R. equi .…”

Section: Discussionmentioning

confidence: 99%

Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

Liang,

Chao,

Sun

et al. 2024

World J Clin Cases

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BACKGROUND Kidney transplantation is the best option for patients with end-stage renal disease. However, the need for lifelong immunosuppression results in renal transplant recipients being susceptible to various infections. Rhodococcus equi (R. equi ) is a rare opportunistic pathogen in humans, and there are limited reports of infection with R. equi in post-renal transplant recipients and no uniform standard of treatment. This article reports on the diagnosis and treatment of a renal transplant recipient infected with R. equi 21 mo postoperatively and summarizes the characteristics of infection with R. equi after renal transplantation, along with a detailed review of the literature. CASE SUMMARY Here, we present the case of a 25-year-old man who was infected with R. equi 21 mo after renal transplantation. Although the clinical features at the time of presentation were not specific, chest computed tomography (CT) showed a large volume of pus in the right thoracic cavity and right middle lung atelectasis, and fiberoptic bronchoscopy showed an endobronchial mass in the right middle and lower lobe orifices. Bacterial culture and metagenomic next-generation sequencing sequencing of the pus were suggestive of R. equi infection. The immunosuppressive drugs were immediately suspended and intravenous vancomycin and azithromycin were administered, along with adequate drainage of the abscess. The endobronchial mass was then resected. After the patient’s clinical symptoms and chest CT presentation resolved, he was switched to intravenous ciprofloxacin and azithromycin, followed by oral ciprofloxacin and azithromycin. The patient was re-hospitalized 2 wk after discharge for recurrence of R. equi infection. He recovered after another round of adequate abscess drainage and intravenous ciprofloxacin and azithromycin. CONCLUSION Infection with R. equi in renal transplant recipients is rare and complex, and the clinical presentation lacks specificity. Elaborate antibiotic therapy is required, and adequate abscess drainage and surgical excision are necessary. Given the recurrent nature of R. equi , patients need to be followed-up closely.

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Section: Discussionmentioning

confidence: 99%

Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

Liang,

Chao,

Sun

et al. 2024

World J Clin Cases

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Pseudotumor of the Tracheal-Laryngeal Junction with Unusual Morphologic Features Caused by Rhodococcus equi Infection

Akilesh

Cross

Kimmelshue

et al. 2011

Head and Neck Pathol

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Infectious pseudotumors are unusual proliferations of histiocytes in response to certain microbial organisms. Occasionally this process may involve large airways, producing a mass lesion that may cause respiratory obstruction. Infectious pseudotumors can be confused with malignancy in their radiologic appearance and clinical presentation. We present a case of an aggressive endotracheal pseudotumor associated with Rhodococcus equi infection in a patient with advanced HIV disease. Microscopically, the lesion was composed of sheets of epithelioid histiocytes with large, strongly eosinophilic intra-cytoplasmic granules and features of malakoplakia. In this report, we review the literature of these unusual lesions and compare them to cases of conventional malakoplakia involving the large airways. We also explore the pathogenetic mechanisms that may contribute to the distinctive histologic appearance of Rhodococcus-associated pseudotumors.

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Rhodococcus equiInfection in HIV-Infected Individuals: Case Reports and Review of the Literature

Topino

Galati

Grilli

et al. 2010

AIDS Patient Care and STDs

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Rhodococcus equi is a gram-positive, coryneform bacterium that causes zoonotic infection mainly in horses and foals. It sometimes affects humans presenting as cavitary pneumonia. Immunocompromised patients, including HIV-infected patients, are more susceptible to R. equi infection. We present 10 cases of R. equi infection in HIV-positive patients admitted to our institute from 1991 to June 2008. Moreover, we have reviewed 272 cases of R. equi infection in HIV-infected persons, published from 1986 through 2008. With respect to the literature data, the R. equi strains isolated in our case series showed lower sensitivity to ceftriaxone, amoxicillin/clavulanic acid, and cotrimoxazole. Prompt diagnosis, early initiation of antiretroviral treatment and combined antimicrobial treatment seem to be effective to eradicate the infection and to improve the outcome.

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Laringitis por rhodococcus equi en paciente con sida

Cited by 3 publications

References 22 publications

Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

Pseudotumor of the Tracheal-Laryngeal Junction with Unusual Morphologic Features Caused by Rhodococcus equi Infection

Rhodococcus equiInfection in HIV-Infected Individuals: Case Reports and Review of the Literature

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