Largest size of extra-abdominal fibromatosis of axilla in a young man

Kumar, Anil; Kumar, Subhash; Sinha, Ruchi; Kumari, Veena

doi:10.1136/bcr-2019-230670

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Factors reported to increase the risk of recurrence include age (younger patients have an increased risk), involved margins, and site of origin (breast or pectoralis). The clinical presentation of DF is broad with initial presentation including an asymptomatic mass in young patients [5,9,10] following surgeries such as a latissimus dorsi myocutaneous pedicled flaps after breast surgery for recurrent breast carcinoma [11][12][13], or can present concomitantly with other types of tumors, for example, in case report showing its presentation after thyroidectomy for papillary thyroid cancer [14].…”

Section: Epidemiologymentioning

confidence: 99%

Desmoid-type Fibromatosis of the Breast. A Literature Review Based on 2 Case Reports

2024

J Oncol Res Ther

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The goal of this review is twofold; to highlight the difficulties in identifying, diagnosing, and treating desmoid-type fibromatosis (DF) of the breast and to discuss the current understanding of the key genetic mutations in the disease process that lead to specific treatment regimens. Currently, there are three groups of DF as classified by the World Health Organization (WHO): abdominal wall, extra-abdominal, and intrabdominal. They all present unique diagnostic challenges; however, the gold standard for diagnosis remains histopathologic confirmation even with the increased availability and sensitivity of imaging modalities. Given the importance of genetic alteration in this disease, the following three genes will be discussed: Catenin Beta 1, Rad51, and Poly Adenosine Diphosphate Ribose Polymerase-1. There is mounting evidence that these could potentially be targets for therapy in addition to surgery alone. Historically, diagnosis and treatment of DF of the breast have been difficult, which leads to a need for an interdisciplinary team approach composed of surgeons, pathologists, radiologists, oncologists, and internists which leads to the best overall care for patients with this pathology.

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