Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome

Deng, Demao; Pang, Yong; Duan, Gaoxiong; Liu, Huimei; Liao, Hai; Liu, Peng; Liu, Yanfei; Li, Shasha; Chen, Wenfu; Wen, Danhong; Xuan, Chunmei; Li, Min

doi:10.1007/s00330-017-5206-0

Cited by 18 publications

(13 citation statements)

References 45 publications

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“…These findings are also broadly consistent with previous evidence showing differences in intrinsic network connectivity between healthy controls and women with PMS, a milder syndrome similar to PMDD. Similar to our finding of stronger connectivity between the left middle temporal gyrus and left ECN compared to controls, Liu et al 18 reported stronger connectivity between the left middle temporal gyrus and default mode network in women with PMS compared to controls. Intriguingly, in both studies, the effect was independent of menstrual cycle phase, despite the dramatic difference in symptom presentation between the follicular and late luteal phases.…”

Section: Discussionsupporting

confidence: 90%

“…Some preliminary forays have investigated the neural features of menstrual-related mood disorders, and differences in functional connectivity between women with Premenstrual Syndrome (PMS, a milder syndrome than PMDD) and healthy controls have been observed. Women with PMS have stronger amygdala-prefrontal cortical connectivity, and connectivity between the right amygdala and right precentral gyrus, left ACC, and left medial prefrontal cortex correlates positively with the strength of symptoms in these patients 18 . A network-level analysis using independent component analysis (ICA) to identify the DMN found stronger connectivity between the DMN and both the superior temporal gyrus and precentral gyrus in women with PMS as compared to healthy controls 19 .…”

Section: Introductionmentioning

confidence: 93%

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Resting-state functional connectivity in women with PMDD

et al. 2019

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BackgroundPremenstrual dysphoric disorder (PMDD) is an understudied, debilitating disorder of women. Given evidence for prefrontal cortical and limbic dysfunction in PMDD, we compared intrinsic connectivity of the executive control network (ECN), default mode network (DMN), and amygdala in women with PMDD vs. controls.MethodsThirty-six women (18 PMDD, 18 control) participated in fMRI during the follicular and luteal phases of the menstrual cycle. At each time, resting-state functional connectivity was evaluated both before and after participants performed an emotion regulation task. The ECN was identified using independent components analysis, and connectivity of left and right amygdala seeds was also evaluated.ResultsNonparametric permutation testing identified a cluster in the left middle temporal gyrus (MTG) with significantly stronger connectivity to the left ECN in women with PMDD vs. controls in all four fMRI sessions. Women with PMDD exhibited no difference in functional connectivity between menstrual cycle phases. Amygdala connectivity did not differ between the groups but differed significantly with menstrual phase, with left amygdala connectivity to cingulate cortex being significantly stronger during the follicular vs. luteal phase. Right amygdala connectivity to the middle frontal gyrus was also stronger during the follicular vs. luteal phase, with no group differences. These findings suggest that women with PMDD have different intrinsic network dynamics in the left executive control network compared to healthy controls.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 93%

Resting-state functional connectivity in women with PMDD

et al. 2019

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“…Women between the ages of 18 and 35, with regular menstrual cycles lasting 21 to 35 days [31][32][33][34], were recruited from the general population using flyers, word-of-mouth referrals and electronic media (Facebook, Instagram, and Craigslist).…”

Section: Study Samplementioning

confidence: 99%

Association between Neuroticism and Premenstrual Affective/Psychological Symptomatology

Hamidovic

Dang

Khalil

et al. 2022

Psychiatry International

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Neuroticism and premenstrual conditions share pleiotropic loci and are strongly associated. It is presently not known which DSM-5 symptoms of premenstrual syndrome/premenstrual mood disorder are associated with neuroticism. We enrolled 45 study participants to provide prospective daily ratings of affective (“depression”, “anxiety, “anger”, “mood swings”) and psychological (“low interest”, “feeling overwhelmed”, and “difficulty concentrating”) symptoms across two-three menstrual cycles (128 total cycles). Generalized additive modeling (gam function in R) was implemented to model the relationships between neuroticism and the premenstrual increase in symptomatology. Significance level was adjusted using the False Discovery Rate method and models were adjusted for current age and age of menarche. Results of the association analysis revealed that “low interest” (p ≤ 0.05) and “difficulty concentrating” (p ≤ 0.001) were significantly associated with neuroticism. None of the remaining symptoms reached statistical significance. The late luteal phase of the menstrual cycle is characterized by complex symptomatology, reflecting a physiological milieu of numerous biological processes. By identifying co-expression between neuroticism and specific premenstrual symptomatology, the present study improves our understanding of the premenstrual conditions and provides a platform for individualized treatment developments.

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“…These alterations may involve regulatory feedback mechanisms related to the menstrual cycle. In contrast, morphological measurements in PMS patients, compared with healthy individuals, indicated significantly enlarged subcortical volumes in the bilateral amygdala (27,28). Moreover, several studies have verified that enhanced functional activity of the amygdala correlated with emotion dysregulation such as degree of anxiety and depression in LP (12,38).…”

Section: Amygdalamentioning

confidence: 97%

The Prominent Role of the Temporal Lobe in Premenstrual Syndrome and Premenstrual Dysphoric Disorder: Evidence From Multimodal Neuroimaging

Long

Wang²,

Liu³

et al. 2022

Front. Psychiatry

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Premenstrual syndrome (PMS) is a group of psychological, physical, and behavioral symptoms that recur with the menstrual cycle, usually occurring a few days before menstruation and ceasing with the onset of menstruation. Premenstrual dysphoric disorder (PMDD) is a severe form of PMS that has been included in a subcategory of depression in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) according to the latest diagnostic criteria. Patients usually present with mild to moderate emotional and physical symptoms that affect their routine work, social activities, and family lives. The pathogenesis of PMDD remains unclear, and some researchers believe that it is related to fluctuations in ovarian hormone levels. However, the details of the interrelationships and regulating effects between ovarian hormones, symptoms, and the brain need to be more comprehensively determined. Recent studies have revealed some novel findings on PMS and PMDD based on brain morphology, function, and metabolism. Additionally, multiple studies have suggested that PMS and PMDD are closely related to brain structural and functional variations in certain core temporal lobe regions, such as the amygdala and hippocampus. We summarized neuroimaging studies of PMS and PMDD related to the temporal lobe by retrospectively reviewing relevant literature over the past decade. This review contributes to further clarifying the significant role of the temporal lobe in PMS and PMDD and understanding the neurochemical links between hormones, symptoms, and the brain.

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Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome

Abstract: • Functional and structural MRI used to explore amygdala in PMS patients. • Aberrant amygdala structural and functional connectivity were found in PMS patients. • Amygdala strength FC was positively correlated with individual clinical symptom scores.

Cited by 18 publications

References 45 publications

Resting-state functional connectivity in women with PMDD

Resting-state functional connectivity in women with PMDD

Association between Neuroticism and Premenstrual Affective/Psychological Symptomatology

The Prominent Role of the Temporal Lobe in Premenstrual Syndrome and Premenstrual Dysphoric Disorder: Evidence From Multimodal Neuroimaging

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