Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis

Noori, Hamid; Linan, Alejandro Cosa; Spanagel, Rainer

doi:10.1016/j.euroneuro.2016.06.013

Cited by 143 publications

(106 citation statements)

References 41 publications

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“…Moreover, a recent meta-analysis (Noori et al, 2016) shows largely overlapping patterns of brain activation common to drug, food, sex and gambling cues including the cerebellum, which strongly supports the involvement of the cerebellum in motivation-related brain circuitry.…”

Section: The Cerebellum In Cravingmentioning

confidence: 72%

The cerebellum in drug craving

Moreno-Rius

Miquel

2017

Drug and Alcohol Dependence

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Craving has been considered one of the core features of addiction. It can be defined as the urge or conscious desire to use a drug elicited by the drug itself, drug-associated cues or stressors. Craving plays a major role in relapse, even after prolonged periods of abstinence, as well as in the maintenance of drug seeking in non-abstinent addicts. The circuitry of craving includes medial parts of the prefrontal cortex, ventral striatal zones, ventral tegmental area, ventral pallidum, and limbic regions. Interestingly, the cerebellum shows reciprocal loops with many of these areas. The cerebellum has been linked traditionally to motor functions but increasing evidence indicates that this part of the brain is also involved in functions related to cognition, prediction, learning, and memory. Moreover, the functional neuroimaging studies that have addressed the study of craving in humans repeatedly demonstrate cerebellar activation when craving is elicited by the presentation of drug-related cues. However, the role of cerebellar activity in these craving episodes remains unknown. Therefore, the main goal of this review is to provide a brief update on craving studies and the traditional neural basis of this phenomenon, and then discuss and propose a hypothesis for the function of the cerebellum in craving episodes.

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Section: The Cerebellum In Cravingmentioning

confidence: 72%

The cerebellum in drug craving

Moreno-Rius

Miquel

2017

Drug and Alcohol Dependence

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“…Both natural and drug reward cues evoked activation in the insula (Noori et al, 2016). In rodents inactivation of the caudal insular cortex decreased operant responding for alcohol along with a corresponding decrease in oral alcohol intake (Pushparaj and Le Foll, 2015).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study

Ide

Zhornitsky

et al. 2017

NeuroImage: Clinical

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Alcohol expectancy and impulsivity are implicated in alcohol misuse. However, how these two risk factors interact to determine problem drinking and whether men and women differ in these risk processes remain unclear. In 158 social drinkers (86 women) assessed for Alcohol Use Disorder Identification Test (AUDIT), positive alcohol expectancy, and Barratt impulsivity, we examined sex differences in these risk processes. Further, with structural brain imaging, we examined the neural bases underlying the relationship between these risk factors and problem drinking. The results of general linear modeling showed that alcohol expectancy best predicted problem drinking in women, whereas in men as well as in the combined group alcohol expectancy and impulsivity interacted to best predict problem drinking. Alcohol expectancy was associated with decreased gray matter volume (GMV) of the right posterior insula in women and the interaction of alcohol expectancy and impulsivity was associated with decreased GMV of the left thalamus in women and men combined and in men alone, albeit less significantly. These risk factors mediated the correlation between GMV and problem drinking. Conversely, models where GMV resulted from problem drinking were not supported. These new findings reveal distinct psychological factors that dispose men and women to problem drinking. Although mediation analyses did not determine a causal link, GMV reduction in the insula and thalamus may represent neural phenotype of these risk processes rather than the consequence of alcohol consumption in non-dependent social drinkers. The results add to the alcohol imaging literature which has largely focused on dependent individuals and help elucidate alterations in brain structures that may contribute to the transition from social to habitual drinking.

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“…Durch die Aufnahme der IGD in das DSM-5 erhielt das Erleben von Craving zusätzlich einen bedeutsamen Fokus, da es somit als wichtiges Diagnosekriterium benannt wurde [Drummond, 2001; [Carter und Tiffany, 1999;Noori et al, 2016].…”

Section: Herleitung Von Theoretischen Annahmen Aus Der Substanzbezogeunclassified

Reizreaktivität und Craving bei Verhaltenssüchten mit Fokus auf Internetnutzungsstörungen

Wegmann

Brand

2018

Verhaltenstherapie

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Verhaltenssüchte sind gekennzeichnet durch das wiederholte Ausüben eines spezifischen Verhaltens unter Missachtung negativer Konsequenzen und des erlebten Kontrollverlusts im Alltag. Zentrale Konstrukte sind dabei Reizreaktivität und Craving, die aus der substanzbezogenen Suchtforschung auch durch aktuelle theoretische Modelle auf die Verhaltenssüchte übertragen werden. Dieser Artikel gibt einen Überblick über theoretische und empirische Arbeiten, die konsistent die Relevanz von Reizreaktivität und Craving als Schlüsselkonzepte auf subjektiver, peripherphysiologischer und neuraler Ebene bei der Entwicklung und Aufrechterhaltung spezifischer Verhaltenssüchte unterstreichen. Ein besonderer Schwerpunkt wird hierbei auf spezifische Internetnutzungsstörungen und die bisherigen empirischen Befunde gelegt. Aus den dargestellten Erkenntnissen werden Empfehlungen für therapeutische Konzepte abgeleitet, die vor allem Reizreaktivität und Craving in den Fokus rücken sollten. Die Wirksamkeit dieser Ansätze sollte in zukünftigen Studien systematisch zur Optimierung therapeutischer Interventionen im Rahmen der Behandlung von Verhaltenssüchten überprüft werden.

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Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis

Cited by 143 publications

References 41 publications

The cerebellum in drug craving

The cerebellum in drug craving

Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study

Reizreaktivität und Craving bei Verhaltenssüchten mit Fokus auf Internetnutzungsstörungen

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