We propose a reaction-diffusion model of spatial pattern formation whose solutions can exhibit scaleinvariance over any desired range for suitable choices of parameters in the model. The model does not invoke preset polarity or any other adboc distinction between cells and provides a solution to the French flag probleit without sources at the boundary. Furthermore, patterns other than the polar pattern that usually arises first in a growing one-dimensional syst6m described by Turing's model can be obtained. Evidence is given that suggests that the model may apply in the slug stage of Dictyostelium discoideum. (5).The assumption that the kinetic and diffusion coefficients in a reaction-diffusion model are constant is certainly only an approximation, and our purpose here is to show that any desired degree of scale-invariance can be achieved via a simple, yet plausible, mechanism by which the overall size of the system is reflected in these coefficients. We treat in detail a case in which it is assumed that the diffusion coefficients of the morphogens depend on the concentration of a diffusible regulatory species that is produced at a constant rate by all cells, and we show that the desired invariance can be obtained by adjusting the production rate and the rate at which the regulatory species leaks into the sourroundings.There are several ways in which such concentration-dependence could arise. For instance, the permeability of the cell membrane (either junctional or ordinary) could be increased by the regulatory species; in the continuum description we adopt here, this would be reflected in an increased diffusion coefficient. Alternatively, the regulatory species could facilitate transport by increasing adsorption of the morphogens on cellular structures, thereby enhancing surface diffusion, or through the formation of specialized transport structures. Recent experimental evidence shows that the postulated effect on membrane permeability actually occurs in some developing systems. For example, the molting hormone ecdysone stimulates a period of increased epidermal communication, as measured by the degree of electrical coupling between cells, in the prepupa stage of the beetle Tenebrio (7), and there is evidence that gap junctions in some amphibian oocytes are hormonally controlled (8). In these examples the source of the regulatory species is, extracellular, but the same effect can be achieved when the source is intracellular.
SCALE-INVARIANCE IN TURING'S MODELLet S denote the region of space occupied by the developing system, whose boundary is assumed to be impermeable to the morphogens but not to the regulatory species, and suppose that transport within S is solely by diffusion. Suppose that there are N morphogens whose concentration is C = (C1, . . ., CN)T, and let CN+ 1 denote the concentration of the regulatory species.We first consider the case in which the regulatory species affects only the morphogen diffusivities and, for simplicity, we assume that the effect is linear in CN+ 1. Then the govern...