R. 2004. Late Neogene-Quaternary evolution of the intermontane Clusone Basin (Southern Alps, Italy): integration of seismic and geological data.ABSTRACT: In the Clusone Basin (a large intermontane basin filled by thick late Neogene-Quaternary sediments in the Middle Val Seriana, Southern Alps), two high-resolution seismic profiles have been acquired in order to reconstruct the geometries of the sediments that fill the depression, with a maximum thickness of more than 200 m as documented by available well data, and to define their relationships with the bedrock, consisting of Late Triassic carbonates. In addition to standard seismic reflection processing, a seismic refraction inversion technique has been applied. The integration of geological (both surface and well data) and seismic data indicates a complex history of the drainage patterns of the Clusone Basin, documenting a shift of the Serio River from a palaeodrainage toward the southeast (Val Borlezza) to the present situation, toward the south (Val Seriana): between the older and the present-day drainages an important depositional stage occurred, as documented by the thick sediments that fill the Clusone Basin, controlling the capture of the Serio River along the Val Seriana.