Large Scale Oxidative Cyclization of ( E )‐Hex‐3‐en‐1‐yl (4‐Methoxyphenyl)sulfamate

Abstract

This chapter describes the procedure for large scale oxidative cyclization of (E)‐Hex‐3‐en‐1‐yl (4‐Methoxyphenyl)sulfamate. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards. The aza ‐Wacker cyclization is a very elegant but relatively underexplored alkene functionalization reaction. To date, most aza ‐Wacker protocols have been developed with alkenyl amines or amides, thus requiring the nitrogen functionality to be native to the molecule.