2004
DOI: 10.1016/j.theochem.2003.12.053
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Large scale MD simulation of 8-oxoguanine and AP site multiple lesioned DNA molecule combined with biomolecular visualization software

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Cited by 2 publications
(2 citation statements)
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“…Besides, short 1ns molecular dynamics simulations were performed for elucidation of the effect of guanine lesion presence in B-DNA [19]. Much larger MD simulation were carried out by Fujimoto et al combined with biomolecular visualization software [20]. However, most of theoretical studies on 8-oxoguanine in B-DNA are related to explanation [21,22] f activities of human oxoguanine glycosylase (hOGG1) [23][24][25][26] and TRF1 binding was analyzed with much lower intensity [27][28][29][30].…”
Section: Introductionmentioning
confidence: 99%
“…Besides, short 1ns molecular dynamics simulations were performed for elucidation of the effect of guanine lesion presence in B-DNA [19]. Much larger MD simulation were carried out by Fujimoto et al combined with biomolecular visualization software [20]. However, most of theoretical studies on 8-oxoguanine in B-DNA are related to explanation [21,22] f activities of human oxoguanine glycosylase (hOGG1) [23][24][25][26] and TRF1 binding was analyzed with much lower intensity [27][28][29][30].…”
Section: Introductionmentioning
confidence: 99%
“…These changes were compared with those of ordinary native (nonlesioned) DNA molecules. One of the six DNA containing clustered damage sites has been recently examined and found to have specific structural conformations 25. Because sequences of each of the six DNA molecules were designed to correspond to those that were used experimentally in previous reports,6, 16, 18, 19 results obtained from simulations presented here are compared with those reported experimentally to gain insights into the MD changes resulting when a second lesion is in close proximity to another lesion in a clustered DNA damage site.…”
Section: Introductionmentioning
confidence: 99%