Large-scale influenza vaccination promotion on a mobile app platform: A randomized controlled trial

Digital intervention increases influenza vaccination rates for people with diabetes in a decentralized randomized trial

“…Engagement rates with the intervention were overall high, with completion rates between 17 and 25% across intervention messages, consistent with digital communication industry standards 20 . The increase in vaccination rate seen in this study is much higher than that previously seen in other general digital interventions for increasing influenza vaccination rates 15 ; it was, however, smaller than that was seen in a prospective interventional study (5% increase) that provided compensation for vaccination 14 . Although compensation was provided for completion of the interventions, the total compensation was only $0.30 per participant, suggesting that this was not a motivating factor for completing the intervention.…”

“…For sample size determination, we estimated a 2.7% increase in vaccination rate between the PWD-I and PWD-C groups. This value was selected to be consistent with prior research and clinically meaningful 14 , 15 . Power analysis indicated the need for an analysis set of 4043 individuals in each arm of the study (total N = 8086) to achieve 80% power to detect a 2.7% increase in vaccination rate with a type I error rate of 0.05 34 .…”

“…One prospective digital interventional study demonstrated the potential effectiveness of general messaging and incentives via a health-related smartphone application (app) to increase vaccine uptake in a general Canadian population 14 , suggesting this kind of intervention could be effective in PWD. A large RCT using digital messaging was also effective in increasing vaccination rates in the general population of adults in the United States 15 . The use of health information technology (e.g., searching the internet for health information, emailing providers) and even simple electronic reminders delivered via digital patient portals have resulted in increased influenza vaccination rates, suggesting the potential of simple digital solutions 16 , 17 .…”

A rapid global review of strategies to improve influenza vaccination uptake in Australia

“…43 The interventions in all these studies reported a modest impact on improving influenza vaccination coverage across large high-risk populations. [40][41][42][43] In contrast to the systematic review findings by Isenor et al 14 recent studies of level III quality [44][45][46][47][48] produced inconsistent results in the effectiveness of a large-scale pharmacy-based vaccine distribution in increasing influenza vaccination rates (Supplementary table 2). Two recent studies 44,45 that reported no association of improved influenza vaccine rates following pharmacist administered vaccination encounters were identified as having a high risk of bias, primarily due to non-randomized design and use of historical control data to compare changes in influenza vaccination rates.…”

“…(iv) Large-scale regional programs Nine studies have evaluated large-scale vaccination interventions in different populations using a variety of approaches alone or in combination. Three RCTs [40][41][42] and one observational study 43 examined the effect of centralized reminder/ recall (autodialer, postcard, text reminders), 40 a state-wide immunization information system (IIS) for seasonal influenza vaccine reminders from local health departments, 41 large-scale messaging using mobile applications 42 and a free national text service providing influenza vaccination education and reminders. 43 The interventions in all these studies reported a modest impact on improving influenza vaccination coverage across large high-risk populations.…”