Large scale genotyping study for asthma in the Japanese population

Imada, Yoshiko; Fujimoto, Masaya; Hirata, Kohji; Hirota, Tomomitsu; Suzuki, Yôichi; Saito, Hirohisa; Matsumoto, Kenji; Akazawa, Akira; Katsunuma, Toshio; Yoshihara, Shigemi; Ebisawa, Motohiro; Shibasaki, Masanao; Arinami, Tadao; Tamari, Mayumi; Noguchi, Emiko

doi:10.1186/1756-0500-2-54

Cited by 12 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another Japanese genomewide asthma study used multiplex PCR-Invader assay methods at 82 935 SNPs in 288 atopic asthmatics and 1032 controls (Stage 1). 38 The associations of SNPs with asthma were further investigated in samples from asthmatic families (216 families, 762 members, Stage 2) and in 541 independent patients and 744 controls (Stage 3). 38 This study failed to find any associations that attained genome-wide significance.…”

Section: Findings In Several Gwa Studies On Asthmamentioning

confidence: 99%

“…38 The associations of SNPs with asthma were further investigated in samples from asthmatic families (216 families, 762 members, Stage 2) and in 541 independent patients and 744 controls (Stage 3). 38 This study failed to find any associations that attained genome-wide significance. Only one SNP in the 5¢ region of PEX19 (rs2820421) was significantly associated with asthma across all three stages of the analyses.…”

Section: Findings In Several Gwa Studies On Asthmamentioning

confidence: 99%

See 1 more Smart Citation

The era of genome-wide association studies: opportunities and challenges for asthma genetics

2009

View full text Add to dashboard Cite

In the era of genome-wide association (GWA) studies, delineating pathogenic asthma genetic pathways has provided both challenges and opportunities. Initial GWA studies on asthma and asthma-like phenotypes provided some successes in terms of ascertaining new potential asthma candidate genes. However, due to asthma having a heterogeneous etiology, replications of these genotype-phenotype association studies are generally lacking. Furthermore, genes by environment interactions are generally not considered when GWA studies are conducted. Therefore, there is a need for extensive collaborations in multi-disciplinary research fields, including different environments and populations, to investigate the functional importance of variations in the human genome in relation to asthma pathogenesis.

show abstract

Section: Findings In Several Gwa Studies On Asthmamentioning

confidence: 99%

Section: Findings In Several Gwa Studies On Asthmamentioning

confidence: 99%

The era of genome-wide association studies: opportunities and challenges for asthma genetics

2009

View full text Add to dashboard Cite

show abstract

“…However, the loci most consistently identified are on chromosomes 2, 5, 6, 11, 12, and 13 because these regions contain a large number of candidate genes (33,34). More recently studies in a Japanese population demonstrate several loci for possible association (35).…”

Section: Discussionmentioning

confidence: 96%

Chromosome Instability on Children with Asthma

Lialiaris

Polyzou

Mpountoukas

et al. 2009

LJAS

View full text Add to dashboard Cite

show abstract

“…Although population stratification was not controlled in this study, we consider the confounding effect of this factor to be of a lesser extent in comparison to studies conducted on North American 35,36 or Western European 37,38 populations. From the genetic point of view, this assumption is based on the fact that our control subjects were residents of the mainland of Japan, the population of which belongs to the genetically homogeneous Hondo cluster, 39 and also on the results of genomic control analysis 40 that showed the populations from the Kinki and Kanto regions (where we recruited our samples and controls) do not differ in the allele frequency of the null marker. In terms of stratification determined by an individual's socioeconomic position, we would refer to the specific egalitarian characteristic of the Japanese society in support of our claim.…”

Section: Discussionmentioning

confidence: 99%

Replication of genetic association studies in asthma and related phenotypes

et al. 2010

Self Cite

View full text Add to dashboard Cite

In asthma genetics, the association of highly replicated susceptibility genes lacks consistency across populations. To identify genuine associations, we investigated the reproducibility of the 23 most promising asthma and asthma-related candidate genes in a moderately sized sample from the Japanese population. We compared the frequency of 33 polymorphisms in unrelated cases and controls and tested for their association with asthma, atopy and serum total IgE levels using allele frequency, codominant, dominant and recessive genotype models. On the basis of the consistency of our findings with previous metaanalyses and large replication studies, IL13, TNF, ADAM33, IL4RA and TBXA2R might represent common major asthma and asthma-related trait genes. Individual gene assessment was extended to the interactions between two polymorphisms using our original method. Interactions between TBXA2R and ADAM33, and IL4RA and C3 were suggested to increase the risk for childhood and all asthma (adult and childhood asthma combined). The confirmation of previously reported associations between gene polymorphisms and phenotypes was problematic when as few as several hundred samples per group were used. Stratification of the subjects by environmental factors or other confounding factors may be necessary to improve the sensitivity and reliability of association results. Keywords: association; asthma; atopy; polymorphism; replication INTRODUCTIONAsthma is a heritable trait 1 and investigations to determine the genetic components underlying asthma using linkage mapping and the candidate gene approach have been carried out. By 2006, more than 100 genes were associated with asthma and asthma-related phenotypes; 2 25 of these genes have been replicated in more than six independent association studies. In 2008, this list was complemented with an additional three genes, FLG, NAT2 and CCL15. 3 However, no single polymorphic marker or gene locus has been unanimously labeled as a strong and independent genetic determinant of asthma, and the results for the highly replicated genes have been inconsistent across the tested populations. 3 To identify true associations, it is of critical importance to comprehensively replicate the initial finding. 4 To this aim, we investigated whether the 23 most replicated genes for asthma and asthma-related phenotypes were positively associated with extrinsic childhood and adult asthma, atopy and total serum IgE levels in a moderately sized sample drawn from the Japanese population.We also tested eight genes that were significantly associated with asthma in our subjects: IL13, 5 TBXA2R, 6 GSTP1, 7 ADAM33, 8 MMP9, 9 IL12B, 10 C3 11 and SOCS1. 12 The re-evaluation of these associations is

show abstract

Large scale genotyping study for asthma in the Japanese population

Cited by 12 publications

References 24 publications

The era of genome-wide association studies: opportunities and challenges for asthma genetics

The era of genome-wide association studies: opportunities and challenges for asthma genetics

Chromosome Instability on Children with Asthma

Replication of genetic association studies in asthma and related phenotypes

Contact Info

Product

Resources

About