Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Abstract

Construction of functional porous titanium scaffold is drawing ever growing attention, due to its effectiveness in solving the mechanical mismatch between titanium implant and bone tissue. However, the poor water permeability as well as the problem in achieving uniform surface modification inside scaffold hinders the further biomedical application of porous titanium scaffold. In this study, largescale functional TiO 2 nanostructures (nanonetwork, nanoplate and nanowire) were constructed on three-dimensional porous titanium scaffolds surface via an effective hydrothermal treatment method. These nanostructures increase the hydrophilicity of the titanium scaffold surface, facilitating the cell culture medium to penetrate into the inner pore of the scaffold. Zeta potential analyses indicate that the surface electrical properties depend on the nanostructure, with nanowire exhibiting the lowest potential at pH 7.4. The influence of the nano-functionalized scaffold on protein adsorption and cell adhesion was examined. The results indicate that the nano-functionalized surface could modulate protein adsorption and bone marrow derived mesenchymal stem cells (BMSCs) adhesion, with the nanowire functionalized porous scaffold homogeneously promoting protein adsorption and BMSCs adhesion. Our research will facilitate future research on the development of novel functional porous scaffold.

Fabricating Honeycomb Titanium by Freeze Casting and Anodizing for Biomedical Applications

“…The results were consistent with the research of Qian et al on the surface micro–nano morphology that could improve the permeability of porous titanium and promote cell adhesion and diffusion. [ 50 ]…”

“…The results were consistent with the research of Qian et al on the surface micro-nano morphology that could improve the permeability of porous titanium and promote cell adhesion and diffusion. [50] 2.6. MG-63 Cell Proliferation Table 1 and Figure 8 present the effects of porous titanium scaffolds with different surface treatments on cell proliferation after coculture with MG-63 cells for 1, 5, 7, and 14 days.…”

Titanium and Protein Adsorption: An Overview of Mechanisms and Effects of Surface Features

“…In the case of FIB, adsorption on hydrothermally treated cp-Ti and Ti64 resulted affected more by topography than WCA [ 121 ]. Protein adsorption on different morphologies obtained by hydrothermal treatments was also related to their surface potential [ 122 ]. High treating temperature, 140 °C, allows to obtain nano-wires on the surface, which exhibit the lowest zeta potential, about −50 mV at pH 7.4, among other nano-structures, such as a nano-network or nano-plate, about −30 and −35 mV at pH 7.4, respectively.…”

Engineering oxygen vacancy on rutile TiO2 for efficient electron-hole separation and high solar-driven photocatalytic hydrogen evolution

“…Since Fujishima and Honda [5][6][7] discovered hydrogen production from water splitting on TiO 2 for the first time, it is considered as the most promising photocatalyst candidate due to nontoxicity, high stability and low-cost [8][9][10]. Therefore, TiO 2 is widely used in photocatalytic degradation of pollutants, photocatalytic hydrogen production, solar cells, photoelectrochemical devices, and so on [11][12][13][14]. It is well-known that TiO 2 has three different crystal phases, anatase, brookite and rutile [15].…”