Large‐Scale Evaluation of Enzyme‐Linked Immunospot Assay and Skin Test for Diagnosis of<i>Mycobacterium tuberculosis</i>Infection against a Gradient of Exposure in The Gambia

Hill, Philip C.; Brookes, Roger H.; Fox, Annette; Fielding, Katherine; Jeffries, David; Jackson-Sillah, Dolly; Lugos, Moses D.; Owiafe, Patrick K.; Donkor, Simon; Hammond, Abdulrahman S.; Otu, Jacob; Corrah, Tumani; Adegbola, Richard A.; McAdam, Keith P. W. J.

doi:10.1086/382362

Cited by 153 publications

(166 citation statements)

References 24 publications

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“…254 One relevant citation 177 was identified by contact with authors. In total, 13 studies [153][154][155]158,166,177,178,[255][256][257][258][259][260] were included in the review.…”

Section: Selection Of Studiesmentioning

confidence: 99%

“…Five 153,166,177,178,258 studies used assays based on ELISPOT (n = 1461), seven 154,155,158,[255][256][257]259 used whole blood interferon-␥ ELISA (n = 2516) and one 260 used an unspecified interferon-␥ assay [peripheral blood mononuclear cells (PBMC) ELISA] (n = 58), including a total of 4035 subjects (Figure 25, Appendix 27). Four studies provided no information on TB exposure.…”

Section: Characteristics and Quality Of Studiesmentioning

confidence: 99%

“…The performance of interferon-␥ assays had been examined comparing test results among groups with high and low TB exposure in nine studies. 154,155,158,166,177,178,256,258,260 Four of the studies 153,255,258,260 (n = 1578) were carried out in high TB prevalence countries.…”

Section: Characteristics and Quality Of Studiesmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

525

361

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) programme, now part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the costs, effectiveness and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as ...

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“…254 One relevant citation 177 was identified by contact with authors. In total, 13 studies [153][154][155]158,166,177,178,[255][256][257][258][259][260] were included in the review.…”

Section: Selection Of Studiesmentioning

confidence: 99%

Section: Characteristics and Quality Of Studiesmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

525

361

View full text Add to dashboard Cite

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“…(35,(50)(51)(52) In the ELISPOT, IFN-γ molecules secreted by cells of the peripheral blood bind specifically to anti-IFN-γ monoclonal antibodies previously immobilized on a plate, avoiding the problem of cytokine consumption during culture, thus increasing the sensitivity of the ELISPOT in comparison with the ELISA.The T SPOT.TB ® assay (Oxford Immunotec, Oxon, UK) uses ESAT-6 and CFP-10 as specific antigens for the stimulation of blood T lymphocytes. This assay is awaiting FDA approval.…”

Section: Initiatives For a Precise Diagnosis Of Tbmentioning

confidence: 99%

“…Most studies demonstrate a concordance ranging from modest to high (60-80%) between the two tests. (52)(53) Various studies suggest that the tests directed at the detection of RD1 antigen-induced IFN-γ production surpass the PPD test in terms of the following characteristics: specificity; correlation with indirect measurements of exposure to M. tuberculosis; lower cross reactivity with BCG vaccination or with infection caused by environmental mycobacteria; and faster laboratory test results. (35,(46)(47) Due to the lack of a standard determinant in the diagnosis of TB, it is impossible to define with precision the sensitivity and specificity of the tests that can quantify IFN-γ production for the diagnosis of latent infection.…”

Section: Initiatives For a Precise Diagnosis Of Tbmentioning

confidence: 99%

Diagnóstico imunológico da tuberculose: problemas e estratégias para o sucesso

Teixeira

Abramo

Munk³

2007

J. bras. pneumol.

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Tuberculosis remains a serious social and public health problem, affecting millions of people annually. The bacille Calmette-Guerin (BCG) vaccine, used prophylactically, does not impede the progression of the disease, which usually manifests as decreased cellular immunity. Early diagnosis, together with polychemotherapy, can control the dissemination of the tuberculosis infection. The current diagnostic methods present certain problems. Such problems include the low sensitivity of sputum smear microscopy, the fact that performing microbiological cultures is quite time-consuming, and the low specificity of the skin test with the purified protein derivative of Mycobacterium tuberculosis.New diagnostic methods, which use specific antigens such as the early secreted antigenic target 6-kDa and culture filtrate protein 10-kDa, are being evaluated. The genes that encode these antigens are located in the DNA region of difference 1 of M. tuberculosis, M. africanum and M. bovis. However, they are absent from the M. bovis (BCG) and from most environmental mycobacteria. Diagnostic methods such as QuantiFERON-TB ® and T SPOT.TB ® , which are based on the production of interferon-gamma by T lymphocytes, in response to those antigens, are being tested and have been found to outstrip the purified protein derivative skin test in the following characteristics: greater sensitivity; lower cross-reactivity due to BCG vaccination or infection with environmental mycobacteria; and execution time. The introduction of diagnostic methods that are more specific and sensitive, together with gaining a better understanding of the molecular and cellular mechanisms that regulate the parasite-host interaction, can increase the efficiency of strategies devised to combat tuberculosis.

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Mycobacterium tuberculosis Infection in Health Care Workers in Rural India

Pai

Gokhale²,

Joshi³

et al. 2005

JAMA

291

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N ESTIMATED ONE THIRD OF the world's population is infected with Mycobacterium tuberculosis, 1 presenting a major impediment to tuberculosis control. Despite the importance of latent tuberculosis infection (LTBI), the tuberculin skin test (TST) was, until recently, the only test available for its diagnosis. [2][3][4][5] The TST measures hypersensitivity response to purified protein derivative (PPD), a crude mixture of antigens, many of which are shared among M tuberculosis, Mycobacterium bovis bacille Calmette-Guérin (BCG), and several nontuberculous mycobacteria (NTM). The TST has limitations with respect to accuracy and reliability. [2][3][4][5][6] Advances in genomics and immunology have led to a promising alternative,

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Large‐Scale Evaluation of Enzyme‐Linked Immunospot Assay and Skin Test for Diagnosis ofMycobacterium tuberculosisInfection against a Gradient of Exposure in The Gambia

Cited by 153 publications

References 24 publications

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Diagnóstico imunológico da tuberculose: problemas e estratégias para o sucesso

Mycobacterium tuberculosis Infection in Health Care Workers in Rural India

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