Large Production System for Hyperpolarized 129Xe for Human Lung Imaging Studies

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129

“…Nonetheless, several avenues exist for substantially improving the Xe129 images using our technique. Ongoing efforts suggest that gas polarizations approximately double those achieved in our studies can be expected in the near future (12). Such a polarization-and hence signal-improvement could be traded for increased spatial resolution.…”

“…Such images were subsequently acquired in animals using repeated inhalations of hyperpolarized Xe129 (5, 10, 11), but with current technology, a multiple-inhalation approach is not feasible in humans. However, with improvements in gas-polarization hardware (12), liter quantities of hyperpolarized Xe129 can be obtained with sufficient polarization to make direct dissolved-phase imaging in humans feasible during a single breath-hold period. Recently, Cleveland et al (13) produced breath-hold images of the dissolved phase in humans following inhalation of 1 L of Xe129.…”

Preservation of Nuclear Spin Order by Precipitation

“…Other cases where spin magnetization is knownt ob ep reserved through phase transitions include dissolution-DNP [6,7] and the freezing and sublimation of hyperpolarized 129 Xe gas [8] or molecules dissolved within. [14,15] In this work, the precipitation and redissolutionw as carried out on as ample of disodium fumarate-1-13 C-2,3-d 2 ,m ixed with disodiumf umarate-2,3-d 2 in a1 :9 ratio, and dissolved in water.…”

“…[1][2][3][4][5][6][7][8][9][10] Clinical studies involving hyperpolarized [1-13 C]pyruvate have been used to monitor tumour metabolism. [2] In vivo imaging studies have also been performed using hyperpolarized [1-13 C]fumarate.…”

“…[1][2][3][4][5][6][7][8][9][10] Clinical studies involving hyperpolarized [1-13 C]pyruvate have been used to monitor tumour metabolism. [2] In vivo imaging studies have also been performed using hyperpolarized [1][2][3][4][5][6][7][8][9][10][11][12][13] C]fumarate. [3] Hyperpolarization methods are limited by an intrinsic longitudinalr elaxation time (T 1 )t hat governst he return of nonequilibriumm agnetization to thermal equilibrium.T he time for extractingt he sample from the hyperpolarizatione quipment, purification, transport, delivery,a nd signal acquisition is often similar to the nuclear T 1 ,m eaning that the polarizer needs to be located close to the point of use.…”