Large paravaginal angiomyofibroblastoma: magnetic resonance imaging findings

Geng, Jie; Hu, Shuqi; Wang, Fujiang

doi:10.1007/s11604-010-0512-3

Cited by 17 publications

(11 citation statements)

References 9 publications

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“…The imaging characteristics that differentiate AMFB from AAM are listed in Table I. While AMFB appears well-circumscribed with strong heterogeneous enhancement, AAM has a strong infiltrative tendency and is poorly circumscribed, while the contrast-enhanced images are characterized by a whorled or swirling growth pattern (9,10).…”

Section: Discussionmentioning

confidence: 99%

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

Shoji

Takeshita

Mukaida

et al. 2017

Molecular and Clinical Oncology

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Abstract.A 50-year-old woman (gravida 2, para 2) first noticed a small nodule in the right labium majus 2 years prior to the initial visit to the Hachinohe Red Cross Hospital (Hachinohe, Japan), which had gradually increased in size. On physical examination, a well-circumscribed, elastic, firm, goose egg-sized, subcutaneous mass protruding from the right labium majus was identified. On magnetic resonance imaging (MRI), the lesion was hypointense on T1-weighted images and was well-circumscribed, strongly enhanced and homogeneous on gadolinium-enhanced images, measuring 7.5x4 cm. The same tumor had measured 2.6 cm on an MRI performed 6 years earlier. Based on the clinical course and imaging findings, angiomyofibroblastoma was diagnosed and surgical resection of the tumor was performed. The tumor was well-circumscribed and highly vascular. The intraoperative blood loss was 70 ml. Histopathologically, the tumor cells were concentrated around blood vessels, were spindle-shaped to oval with mild atypia, and were positive for vimentin, desmin, neural cell adhesion molecule (N-CAM), CD-34, estrogen receptor and progesterone receptor, and negative for S-100. Based on these findings, the diagnosis of angiomyofibroblastoma was confirmed. Angiomyofibroblastoma is a benign mesenchymal tumor that occurs in the female external genitalia. Differentiation of this tumor from aggressive angiomyxoma, a fast-growing infiltrative malignancy that occurs in the same region, may be challenging. The diagnosis of angiomyofibroblastoma is usually based on the histopathological findings of the resected specimen. The present case is of value, as the angiomyofibroblastoma was successfully diagnosed preoperatively based on the clinical course and imaging findings.

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Section: Discussionmentioning

confidence: 99%

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

Shoji

Takeshita

Mukaida

et al. 2017

Molecular and Clinical Oncology

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“…All report a mass with well-defined margins and as in our case they have been found to appear as a heterogeneous signal intensity on T2-weighted MRI. All other cases reported fast and persistent enhancement on dynamic gadolinium-enhanced MRI whereas ours showed only mild enhancement [15, 16]. …”

Section: Discussionmentioning

confidence: 59%

A Vaginal Angiomyofibroblastoma as a Rare Cause of a Prolapsing Vaginal Mass: A Case Report and Review of the Literature

Calvert

Kapurubandara

Nikam

et al. 2018

Case Reports in Obstetrics and Gynecology

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Introduction Angiomyofibroblastoma (AMFB) is a rare, benign, mesenchymal cell tumour which presents as a slow-growing mass. It is most commonly seen in the vulva and is often mistaken for Bartholin's abscess. It is histologically diagnosed by the presence of stromal cells intermingled with small blood vessels. It is morphologically similar to cellular angiofibroma and aggressive angiomyxoma, the latter of which is locally invasive and has a possibility of metastasis and a high risk of local recurrence. There is one reported case of an AMFB undergoing sarcomatous transformation. Case Report We report a case of a multiparous, 36-year-old woman with an anterior vaginal mass which was inappropriately treated as a vaginal prolapse prior to definitive surgical management. This is only the second reported case of an AMFB presenting as a prolapsing mass.

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“…The deep pink areas are hypercellular with numerous spindle cells set in dense collagen, reflected as low T 2 signal avidly enhancing area. Geng et al 11 made a similar observation when discussing the imaging features in a report of an angiomyofibroblastoma, another type of mesenchymal tumour. The similarity in MRI signal characteristics reflects similar variably dense areas within these proliferations.…”

Section: Discussionmentioning

confidence: 64%

Superficial myofibroblastoma of the lower female genital tract with description of the MRI features

et al. 2017

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Superficial myofibroblastomas of the lower female genital tract are an unusual type of benign mesenchymal tumour. To the authors’ knowledge, there has been no previous imaging description of a superficial myofibroblastoma in the literature. Here, we describe a case that presented with symptoms consistent with vaginal prolapse. However, a mass was palpable on clinical examination with unusual features on MRI. Following surgery, the histopathological features were considered consistent with superficial myofibroblastoma. By presenting the MRI and histological findings, we aim to raise awareness about this lesion so that it may be considered in the differential diagnosis of a vaginal mass.

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Large paravaginal angiomyofibroblastoma: magnetic resonance imaging findings

Cited by 17 publications

References 9 publications

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

A Vaginal Angiomyofibroblastoma as a Rare Cause of a Prolapsing Vaginal Mass: A Case Report and Review of the Literature

Superficial myofibroblastoma of the lower female genital tract with description of the MRI features

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