Large neurotoxic amygdala lesion impairs reinforcement omission effects

Tavares, Tatiane Ferreira; Judice-Daher, Danielle Marcilio; Bueno, José Lino Oliveira

doi:10.1016/j.bbr.2014.02.026

Cited by 8 publications

(14 citation statements)

References 25 publications

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“…Furthermore, fluorogold injections in the SNc demonstrate these c-fos positive CeA cells project to the SNc [89], implicating a CeA-SNc pathway in the detection of changes in reward contingencies. Lesions of the CeA produce a mild impairment in performance when an expected reward of small magnitude is omitted [90]; however, lesions of the entire CeA and BLA combined substantially reduce sensitivity to omission and so the specific contribution of the CeA is somewhat unclear [91].…”

Section: The Cea In Instrumental Learningmentioning

confidence: 99%

The Contribution of the Amygdala to Reward-Related Learning and Extinction

Chesworth¹,

Corbit²

2017

The Amygdala - Where Emotions Shape Perception, Learning and Memories

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There has been substantial research into the role of the amygdala in fear conditioning and extinction of conditioned fear. The role of the amygdala in appetitive conditioning is relatively less explored. Here, we will review research into the role of the amygdala in reward-related learning. Research to date suggests that the basolateral and central amygdala are responsible for learning about distinct aspects of a reinforcing event. For example, the basolateral amygdala is essential for distinguishing and choosing between specific rewards based on the specific-sensory properties of those rewards as well as updating the relative value of specific rewarding events. In contrast, the central amygdala is involved in encoding reinforcement more generally and for regulating motivational influences on responding. We will also review what is known about the role of the amygdala in extinction of reward-related behaviours and highlight areas for future research.

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Section: The Cea In Instrumental Learningmentioning

confidence: 99%

The Contribution of the Amygdala to Reward-Related Learning and Extinction

Chesworth¹,

Corbit²

2017

The Amygdala - Where Emotions Shape Perception, Learning and Memories

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“…This form of urgency is particularly interesting because it serves as a predictor of problem drinking and smoking in children as young as fifth grade (Settles et al, 2012), and is associated with cocaine dependence (Albein-Urios, et al, 2012; Verdejo-Garcia et al, 2008; Whiteside and Lynam, 2003). The neural mechanisms underlying negative urgency are purported to involve an imbalance of functional connectivity between cortical, striatal, and limbic areas (Cyders and Smith, 2008; Gipson et al, 2012; Judice-Daher and Bueno, 2013; Judice-Daher et al, 2012; Tavares, Judice-Daher, and Bueno, 2014). Repeated cocaine use impairs global functioning of frontal cortex, which manifests as hypofrontality, but also causes damage locally in orbito-frontal cortex, resulting in impairments in judgment and cognitive flexibility, as well as in increased impulsivity (Albein-Urios et al, 2013; Stalnaker et al, 2007a; Stalnaker et al, 2007b; Stalnaker, 2007c; Zuo, et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Cocaine withdrawal alters the reward omission effect and enhances traits of negative urgency in rats across multiple days of testing

Barker

Rebec

2016

Drug and Alcohol Dependence

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Background The personality trait of negative urgency, characterized as behaving rashly when emotionally perturbed, is gaining attention as an indicator for susceptibility to problematic substance use. How this trait is influenced by exposure to drugs of abuse is still unclear. Using an animal model of binge cocaine consumption, we tested this relationship in a reward-omission task across multiple days. Methods Adult, male, Sprague-Dawley rats received seven daily (ip) injections of saline, cocaine (10-20 mg/kg), or cocaine (20-40 mg/kg). Cocaine doses increased linearly each day from the lower to the higher dose. A separate group received RTI-113 (3.0 mg/kg), a selective dopamine transporter inhibitor, for 7 days. Fifteen days after their final injection, rats were trained on a reward-omission task with an operant component to earn further rewards. Results Previous exposure to cocaine resulted in dose-dependent increases in negative urgency in separate behavioral variables across days of testing. The lower dose range increased negative urgency on the dimension of decreased reaction time to press a lever, while the higher dose range increased the rate of increase in lever presses made per trial. Rats receiving RTI-113 did not resemble either cocaine group and instead showed a decrease in lever pressing across days. Conclusions Our results indicate that previous binge cocaine consumption enhances behavioral markers of negative urgency in a dose-dependent, time-sensitive manner on discrete behavioral dimensions. The results with RTI-113 suggest the relationship between cocaine exposure and negative urgency is unlikely to be explained solely by inhibition of dopamine reuptake.

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“…Os resultados obtidos em nosso laboratório, em conjunto Judice-Daher et al, 2012;Bueno, Bernardes & Judice-Daher, 2012;Tavares et al, 2014) sugerem que a amígdala está envolvida, de alguma forma, na modulação dos efeitos de omissão do reforço.…”

Section: Lesão Da Amígdala E Efeitos De Omissãounclassified

“…Os resultados do presente trabalho corroboram com a ideia de que os EORs podem também ser compreendidos como resultado de uma supressão comportamental após o reforçamento (Seward, Pereboom, Butler, & Jones, 1957) e de que o reforço adquire controle inibitório temporal (Staddon, 1974;Staddon & Innis, 1969 (Tavares et al, 2014), lesões em outras estruturas corticais (Judice et al, 2013) e mudanças no repertório comportamental dos animais .…”

Section: Núcleo Accumbens E Omissão De Reforçounclassified

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Efeitos da omissão do reforço sobre o repertório comportamental em ratos com lesão do núcleo accumbens

Bernardes¹

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Large neurotoxic amygdala lesion impairs reinforcement omission effects

Cited by 8 publications

References 25 publications

The Contribution of the Amygdala to Reward-Related Learning and Extinction

The Contribution of the Amygdala to Reward-Related Learning and Extinction

Cocaine withdrawal alters the reward omission effect and enhances traits of negative urgency in rats across multiple days of testing

Efeitos da omissão do reforço sobre o repertório comportamental em ratos com lesão do núcleo accumbens

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