Large Meta-Analysis in the CHARGE Consortium Provides Evidence For an Association of Serum Vitamin D With Pulmonary Function

Abstract

was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/144717 doi: bioRxiv preprint first posted online 4 ABSTRACT Background Epidemiological studies have reported mixed cross-sectional findings for the

Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function: A Randomized Controlled Trial

“…To our knowledge, this is the first study to show that vitamin D supplementation (compared to placebo) increases FEV1 and FEV1 z -score in ever-smokers. The restriction of this effect to ever-smokers only is consistent with observational research, which has shown stronger 25(OH)D-lung function associations among smokers [ 1 , 17 , 18 , 19 ] and a stronger smoking-FEV1 relationship in vitamin D-deficient people [ 2 ]. Taken together, these findings suggest that vitamin D supplementation may mitigate smoking-associated lung function damage, although smoking avoidance and cessation remain paramount for preserving lung health.…”

“…Trials should also investigate vitamin D-deficient people and smokers, as vitamin D supplementation could potentially be more effective in these people. This is because non-linear relationships between 25(OH)D and health outcomes suggest that adverse effects associated with low vitamin D status are greatest in vitamin D-deficient people [ 14 , 15 , 16 ], while observational studies suggest that the relationship between 25(OH)D and lung function could be stronger in smokers than in non-smokers [ 1 , 17 , 18 , 19 ].…”