Large granular lymphocytosis in a cynomolgus macaque (Macacafascicularis) with a subclinical Trypanosomacruzi infection

Henderson, Sally E.; Pfeiffer, Sara C.; Novak, Joseph P.; Peace, Tracy A.

doi:10.1111/vcp.12879

Cited by 3 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Beagle dogs infected by different T. cruzi strains showed a positive correlation between leukocytosis, lymphocytosis and parasitemia peaks (73,74). The same correlation was found in cynomolgus macaque (Macaca fascicularis) naturally infected by T cruzi (75) and in Rhesus monkeys experimentally infected with T cruzi Colombian strain (76). Previous studies conducted by our group, also found a positive correlation between parasitemia levels and leukocytes counts in Swiss mice infected by T. cruzi SC2005.…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Host Genetics Background Influence in the Intragastric Trypanosoma cruzi Infection

et al. 2020

View full text Add to dashboard Cite

BackgroundConsidering the complexity of the factors involved in the immunopathology of Chagas disease, which influence the Chagas’ disease pathogenesis, anti-T. cruzi immune response, and chemotherapy outcome, further studies are needed to improve our understanding about these relationships. On this way, in this article we analyzed the host genetic influence on hematological, histopathological and immunological aspects after T. cruzi infection.MethodsBALB/c and A mice were intragastrically infected with T. cruzi SC2005 strain, isolated from a patient of an outbreak of Chagas disease. Parameters such as parasite load, survival rates, cytokines production, macrophages, T and B cell frequencies, and histopathology analysis were carried out.ResultsBALB/c mice presented higher parasitemia and mortality rates than A mice. Both mouse lineages exhibited hematological alterations suggestive of microcytic hypochromic anemia and histopathological alterations in stomach, heart and liver. The increase of CD8+ T cells, in heart, liver and blood, and the increase of CD19+ B cells, in liver, associated with a high level of proinflammatory cytokines (IL-6, TNF-α, IFN-γ), confer a resistance profile to the host. Although BALB/c animals exhibited the same findings observed in A mice, the response to infection occurred later, after a considerable parasitemia increase. By developing an early response to the infection, A mice were found to be less susceptible to T. cruzi SC2005 infection.ConclusionsHost genetics background shaping the response to infection. The early development of a cytotoxic cellular response profile with the production of proinflammatory cytokines is important to lead a less severe manifestation of Chagas disease.

show abstract

Section: Discussionsupporting

confidence: 85%

“…The enhancement of these T cell subpopulations occurred at the parasitemia peak and persisted until the end of the infection when there was a reduction of parasite load. It is occur probably due to cytotoxic activity of these cells, as reported previously (75).…”

Section: Discussionsupporting

confidence: 76%

Host Genetics Background Influence in the Intragastric Trypanosoma cruzi Infection

et al. 2020

View full text Add to dashboard Cite

show abstract

Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi: a scoping review

Sánchez Pérez,

Aranda-Coello,

De Fuentes Vicente

et al. 2024

Animal Diseases

View full text Add to dashboard Cite

Trypanosoma cruzi is the etiologic agent of Chagas disease. This flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family (known as “kissing bugs”). Despite the fact that hundreds of species of wild mammals are part of the reservoir system, the morphological changes and clinical manifestations resulting from the pathogenesis of the infection have been largely neglected. The aim of this review is to systematically compile the available information regarding clinicopathological alterations in wild mammals due to natural infection by T. cruzi. Information was obtained from six online bibliographic data search platforms, resulting in the identification of 29 publications that met the inclusion criteria. Mortality was the most common clinical manifestation, cardiac damage was the main finding at necropsy, and lymphoplasmacytic inflammation was the most frequent microscopic injury. Thus, regardless of its role as a reservoir, T. cruzi has the potential to affect the health status of wild mammals, a situation that highlights the need for further research to analyze, measure, and compare its effects at both the individual and population levels.

show abstract

How Do Mouse Strains and Inoculation Routes Influence the Course of Experimental Trypanosoma cruzi Infection?

Cardoso¹,

Domingues²,

Valle³

et al. 2022

Chagas Disease - From Cellular and Molecular Aspects of Trypanosoma Cruzi-Host Interactions to the Clinical Intervention

View full text Add to dashboard Cite

Chagas’ disease outcomes depend on several factors including parasite and host genetics, immune response, and route of infection. In this study, we investigate the influence of inoculation route and host genetic background on the establishment and development of Chagas disease in mice, using an isolate of Trypanosoma cruzi SC2005 strain (TcII), which was obtained from an oral Chagas’ disease outbreak in Santa Catarina, Brazil. Comparative analysis of the immunopathological, histopathological, and hematological profiles of mice was performed demonstrating the influence of the route of infection in disease severity. In outbred mice, intraperitoneal (IP) infection led to higher infection and mortality rates and more severe parasitaemia, when compared with intragastric (IG) infection. Nevertheless, tissue colonization was similar, showing severe damage in the heart, with intense lymphocytic inflammatory infiltrates, regardless of the route of infection. On the other hand, in mice IG-infected, the host genetic background influences the start timing of immune response against Trypanosoma cruzi. The susceptible BALB/c inbred mouse strain presented an earlier development of a cytotoxic cellular profile, when compared with A mice. We hypothesize that the cytotoxic response mounted before the parasitaemia increase allowed for a milder manifestation of Chagas’ disease in intragastrically infected mice.

show abstract

Large granular lymphocytosis in a cynomolgus macaque (Macacafascicularis) with a subclinical Trypanosomacruzi infection

Cited by 3 publications

References 19 publications

Host Genetics Background Influence in the Intragastric Trypanosoma cruzi Infection

Host Genetics Background Influence in the Intragastric Trypanosoma cruzi Infection

Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi: a scoping review

How Do Mouse Strains and Inoculation Routes Influence the Course of Experimental Trypanosoma cruzi Infection?

Contact Info

Product

Resources

About