Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Dunne, Jessica L.; Richardson, Sarah J.; Atkinson, Mark A.; Craig, Maria E.; Dahl‐Jørgensen, Knut; Flodström‐Tullberg, Malin; Hyöty, Heikki; Lloyd, Richard E.; Morgan, Noel G.; Pugliese, Alberto

doi:10.1007/s00125-019-4873-6

Cited by 3 publications

(2 citation statements)

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“…Nevertheless, due to the asymptomatic nature of some acute infections, it is unlikely that we can diagnose these pathologies in the early stages, as healthy populations will never get sampled. The therapeutic options are to develop preventive vaccination, as explained by Dunne et al [63], or to find ways to reverse tissue damage and remodeling in patients. For both options, a comprehensive understanding of cell-specific replication determinants and the pathogenic effects on infected tissues is critical to better anticipate these events and design therapeutic strategies.…”

Section: Discussionmentioning

confidence: 99%

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation

Bouin

Semler

2020

Curr Clin Micro Rpt

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Purpose of Review To highlight recent findings on how picornavirus infections of the airways and cardiac tissues impact cellular inflammation and remodeling events. Recent Findings Recent published work has revealed that although many picornavirus infections appear to be initially asymptomatic, there are significant disease sequelae that result from chronic or persistent infections and the long-term, pathogenic effects on host tissues. Summary Because many acute picornavirus infections are asymptomatic, it is difficult to diagnose these pathologies at the early stages of disease. As a result, we must rely on preventative measures (i.e., vaccination) or discover novel treatments to reverse tissue damage and remodeling in affected individuals. Both of these strategies will require a comprehensive knowledge of virusand cell-specific replication determinants and how these processes induce pathogenic effects in infected cells and tissues.

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Section: Discussionmentioning

confidence: 99%

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation

Bouin

Semler

2020

Curr Clin Micro Rpt

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“…A placebo-controlled trial of antivirals to control T1D is currently taking place in Norway. We eagerly await the results of that effort [52][53][54].…”

Section: Ljungan Virus Associated With Diabetes In Humans?mentioning

confidence: 99%

Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?

Klitz

Niklasson

2020

Microorganisms

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We found an association between the abundance of rodents in the wild and onset of type 1 diabetes (T1D) in humans. A picornavirus named Ljungan virus (LV) was subsequently isolated from wild bank voles. Both picornavirus-like particles detected by electron microscopy and LV antigen visualized by immunohistochemistry was seen in islets of Langerhans in diabetic wild bank voles. LV antigen has also been found in islets of Langerhans in a patient with recent onset of T1D and in the commonly used Bio Breeding (BB) T1D rat model. We discuss the possibility of T1D and type 2 diabetes (T2D) as parts of a single disease entity. Antiviral compounds directed against picornavirus have been found to be an effective treatment of diabetes in BB rats. We propose using the same currently available antiviral compounds in clinical trials in humans. Antiviral treatment would have the potential to be both proof of concept for involvement of a picornavirus in diabetes pathogenesis and also present a first-generation therapy.

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Changing the landscape for type 1 diabetes: the first step to prevention

et al. 2019

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Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Cited by 3 publications

References 20 publications

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation

Extending the Enterovirus Lead: Could a Related Picornavirus be Responsible for Diabetes in Humans?

Changing the landscape for type 1 diabetes: the first step to prevention

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