Large-duct cholangiopathies: aetiology, diagnosis and treatment

Abstract

Cholangiopathies describe a group of conditions affecting the intrahepatic and extrahepatic biliary tree. Impairment to bile flow and chronic cholestasis cause biliary inflammation, which leads to more permanent damage such as destruction of the small bile ducts (ductopaenia) and biliary cirrhosis. Most cholangiopathies are progressive and cause end-stage liver disease unless the physical obstruction to biliary flow can be reversed. This review considers large-duct cholangiopathies, such as primary sclerosing cholangitis, ischaemic cholangiopathy, portal biliopathy, recurrent pyogenic cholangitis and Caroli disease.

17q12 Recurrent Deletions and Duplications: Description of a Case Series with Neuropsychiatric Phenotype

“…Furthermore, Patient 7 had a cryptogenic cholangiopathy which may be related to 17q12 microdeletion, since elevated hepatic transaminase enzyme levels, cholestasis, liver abnormalities involving choledochal, and bile duct cysts have been reported [9]. We cannot exclude the possibility that chemokines involvement in this broader deletion may have also contributed to this hepatic disorder, which often has an inflammatory origin [35].…”

Progressing pancreaticobiliary medicine in the UK

“…[1][2][3][4][5][6][7] These discuss the diagnosis and management of-plus recent advances in-acute and chronic pancreatitis, immunoglobulin (Ig)G4-related disease, pancreatic cysts, pancreatic cancer, pancreatic neuroendocrine tumours and cholangiopathies. The papers would form the basis of developing the training curriculum for junior gastroenterologists interested in the subspeciality.…”

Diffuse Oligosymptomatic Caroli’s Disease: Case Report

“…2 It is most often revealed by recurrent episodes of cholangitis. 3 Hematological and biochemical examinations were normal (Table 1). There was no cholestasis or cytolysis.…”