Large Dipole Moments of Phosphorus-Containing Dendrimers

Lartigue, Marie-Laure; Donnadieu, Bruno; Galliot, Christophe; Caminade, Anne‐Marie; Majoral, Jean‐Pierre; Fayet, Jean-Pierre

doi:10.1021/ma970570s

Cited by 154 publications

(124 citation statements)

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“…The hydrodynamic radius (Rh) of generation 4 with aldehyde terminal groups and of generation 5 with ammonium terminal groups was measured by diffusion NMR (pulse gradient spin-echo) experiments. Rh decreased from 35.4 Å at 4 mol % of water to 32.5 Å at 64 mol % of water in THF for G 4 CHO, and from 41 Å at 90 mol % of water to 30 Å at 100 mol % of water for G 5 N + [12], showing in both cases the hydrophobic nature of these dendrimers. Furthermore, 1 H-NMR spectra carried out in pure water displayed only the signals corresponding to the ammonium terminal groups, but in water/THF mixtures, the signals corresponding to the internal structure were recovered ( Figure 2).…”

Section: Functional Cores Of Dendrimers (Type A)mentioning

confidence: 93%

“…Each time a new layer of branching points is created, a new generation is obtained. High generations have been obtained in some cases: generation 9 for polyphenylene dendrimers [1], generation 10 for PAMAM dendrimers [2] and for polylysine dendrimers [3], generation 12 for phosphorhydrazone dendrimers [4], and recently generation 13 for triazine dendrimers [5]. In most cases, the internal structure has no specific function usable for further functionalization, and all the terminal functions are identical.…”

Section: Introductionmentioning

confidence: 99%

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Bifunctional Phosphorus Dendrimers and Their Properties

Caminade

Majoral

2016

Molecules

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Dendrimers are hyperbranched and monodisperse macromolecules, generally considered as a special class of polymers, but synthesized step-by-step. Most dendrimers have a uniform structure, with a single type of terminal function. However, it is often desirable to have at least two different functional groups. This review will discuss the case of bifunctional phosphorus-containing dendrimers, and the consequences for their properties. Besides the terminal functions, dendritic structures may have also a function at the core, or linked off-center to the core, or at the core of dendrons (dendritic wedges). Association of two dendrons having different terminal functions leads to Janus dendrimers (two faces). The internal structure can also possess functional groups on one layer, or linked to one layer, or on several layers. Finally, there are several ways to have two types of terminal functions, besides the case of Janus dendrimers: either each terminal function bears two functions sequentially, or two different functions are linked to each terminal branching point. Examples of each type of structure will be given in this review, as well as practical uses of such sophisticated structures in the fields of fluorescence, catalysis, nanomaterials and biology.

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Section: Functional Cores Of Dendrimers (Type A)mentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Bifunctional Phosphorus Dendrimers and Their Properties

Caminade

Majoral

2016

Molecules

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“…Dendrimers are synthesized generation after generation, step by step. The state of the art is reached with this phosphorus containing dendrimers series: the 12th generation; but details of synthesis of this amorphous polymers are published elsewhere [2,3]. Numbering of these compounds hereafter will be done as follows:…”

Section: Sub-glass Transition Region: Secondary Relaxation In Dendrimersmentioning

confidence: 99%

Dielectric relaxations in amorphous polymers with complex chain architectures

Dantras

Dudognon

Samouillan

et al. 2002

Journal of Non-Crystalline Solids

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. Abstract By combining thermostimulated current and dynamic dielectric spectroscopies, the dielectric properties characteristic of the molecular mobility can be described over a very broad frequency range. The study of dielectric relaxations of phosphorus-containing dendrimers in the sub-glass transition region, and of poly(n-alkyl methacrylates) at and above the glass transition region allows us to gain insight into the molecular dynamics of complex architecture systems. From these sets of data we make an attempt to propose a structural interpretation of molecular mobility through the glass transition.

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“…We will focus this review on the most salient biological properties of the phosphorhydrazone dendrimers that we synthesize. These dendrimers are synthesized starting from a trifunctional core (P(S)Cl 3 ) (Lartigue et al, 1997), or a hexafunctional core (N 3 P 3 Cl 6 ) (Launay et al, 1997) as shown in Figure 2. The phosphorhydrazone linkage (P-N-N=CH) is created by the condensation reaction of a phosphorhydrazide with an alhedyde.…”

Section: Introductionmentioning

confidence: 99%

Biological properties of water-soluble phosphorhydrazone dendrimers

Caminade

Turrin

Majoral

2013

Braz. J. Pharm. Sci.

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1984-8250Dendrimers are hyperbranched and perfectly defined macromolecules, constituted of branches emanating from a central core in an iterative fashion. Phosphorhydrazone dendrimers constitute a special family of dendrimers, possessing one phosphorus atom at each branching point. The internal structure of these dendrimers is hydrophobic, but hydrophilic terminal groups can induce the solubility of the whole structure in water. Indeed, the properties of these compounds are mainly driven by the type of terminal groups their bear; this is especially true for the biological properties. For instance, positively charged terminal groups are efficient for transfection experiments, as drug carriers, as anti-prion agents, and as inhibitor of the aggregation of Alzheimer's peptides, whereas negatively charged dendrimers have anti-HIV properties and can influence the human immune system, leading to anti-inflammatory properties usable against rheumatoid arthritis. This review will give the most representative examples of the biological properties of water-soluble phosphorhydrazone dendrimers, organized depending on the type of terminal groups they bear

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Large Dipole Moments of Phosphorus-Containing Dendrimers

Cited by 154 publications

References 4 publications

Bifunctional Phosphorus Dendrimers and Their Properties

Bifunctional Phosphorus Dendrimers and Their Properties

Dielectric relaxations in amorphous polymers with complex chain architectures

Biological properties of water-soluble phosphorhydrazone dendrimers

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