Compact Type IIB D = 4, N = 1 orientifolds have certain U (1) σ-model symmetries at the level of the effective Lagrangian. These symmetries are generically anomalous.We study the particular case of Z N orientifolds and find that these anomalies may be cancelled by a generalized Green-Schwarz mechanism. This mechanism works by the exchange of twisted RR-fields associated to the orbifold singularities and it requires the mixing between twisted and untwisted moduli of the orbifold. As a consequence, the Fayet-Iliopoulos terms which are present for the gauged anomalous U (1)'s of the models get an additional untwisted modulus dependent piece at the tree level.