Large artery stiffness and pulse wave reflection: Results of a population‐based study

Filipovský, Jan; Tichá, M.; Cífková, Renata; Lánská,; Stastná,; Roučka, Patrik

doi:10.1080/08037050510008814

Cited by 47 publications

(37 citation statements)

References 16 publications

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“…24,[36][37][38][39][47][48][49][50][51][52][53]63 However, a few other studies did not consistently find this effect. 32,[40][41][42] For example, Filipovsky et al 41 and Rehill et al 42 found that AIx was significantly higher in smokers than in nonsmokers, while differences in PWV did not reach significance. Kool et al 32 also did not find significant differences between smokers and nonsmokers when measuring compliance and distensibility; however, they only included 14 nonsmokers.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, three different groups found no significant correlation between smoking status and increased cfPWV. [41][42][43] However, AIx was increased in smokers (17.25%) compared with nonsmokers (11.75%; P¼0.004) in one of the same subject Smoking and arterial stiffness RJ Doonan et al Smoking and arterial stiffness RJ Doonan et al populations. 42 A number of other studies found AIx to be increased in chronic smokers compared with nonsmokers.…”

Section: Chronic Smokingmentioning

confidence: 99%

“…42 A number of other studies found AIx to be increased in chronic smokers compared with nonsmokers. 24,41,44,45 Furthermore, Tomiyama et al 46 showed that AIx was independently correlated with smoking status in men and women. Some of the identified studies evaluated arterial stiffness using ultrasonographic methods: SI, distensibility and compliance.…”

Section: Chronic Smokingmentioning

confidence: 99%

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The effect of smoking on arterial stiffness

et al. 2010

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A systematic literature review was conducted using PubMed, Embase and the Cochrane Library to determine the effect of acute, chronic and passive smoking on arterial stiffness and to determine whether these effects are reversible after smoking cessation. A total of 39 relevant studies were identified and included. Acute smoking was found to cause an acute increase in arterial stiffness. Similarly, passive smoking increased arterial stiffness acutely and chronically. The majority of studies identified chronic smoking as a risk factor for increasing arterial stiffness. However, some studies found no statistical difference in arterial stiffness between nonsmokers and long-term smokers, although chronic smoking seems to sensitize the arterial response to acute smoking. In addition, whether arterial stiffness is reversed after smoking cessation and the timeline in which this may occur could not be determined from the identified literature. The effect of smoking discontinuation on arterial stiffness remains to be established by prospective smoking cessation trials.

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Section: Discussionmentioning

confidence: 99%

Section: Chronic Smokingmentioning

confidence: 99%

Section: Chronic Smokingmentioning

confidence: 99%

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The effect of smoking on arterial stiffness

et al. 2010

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“…17,18 Arterial stiffness was assessed by pulse wave velocity (PWV), measured in supine position in the aorta, that is, between carotid and femoral arteries (aortic PWV, APWV) and in the lower extremity, that is, between femoral and dorsalis pedis or tibialis posterior arteries (peripheral PWV, PPWV). Consecutive registrations of the pulse waves are electrocardiogram gated and thus, the time shift between the appearance of wave at the first and the second sites can be calculated.…”

Section: Methodsmentioning

confidence: 99%

Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffness

et al. 2007

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Angiotensin II and nitric oxide belong to important factors in the functional and structural changes of vessel wall, leading to its increased stiffness. We investigated, whether common mutations of angiotensin II type 1 receptor (AGTR 1 ) and endothelial nitric oxide synthase (eNOS) are associated with increased arterial stiffness. Two polymorphisms, A 1166 C of AGTR 1 and T 786 C of Enos, were estimated in a random, general population-based sample of 250 subjects. Arterial stiffness was measured using Sphygmocor as aortic (carotid-femoral) and peripheral (femoral-tibial) pulse wave velocities (PWV). Carriers of 3-4 mutant alleles from both polymorphisms, that is, homozygous for both mutations or homozygous for one and heterozygous for the second one, showed significantly higher peripheral PWV (17.9272.40) than those with none or only 1-2 mutant alleles (12.3770.51; Po0.003). Carriers of 3-4 mutant alleles had three times higher risk of having increased peripheral PWV (X13.63 m s À1 , that is, in the top quartile) and this association remained significant after adjustment for potential confounders. No association was found between estimated genotypes and aortic PWV. In conclusion, combination of A 1166 C of AGTR 1 and T 786 C of eNOS mutations increased stiffness of muscular-type arteries.

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“…11 The first part of this examination was the registration of radial pulse wave which was used to evaluate wave reflection; the parameter showing wave reflection is augmentation index (AIx), defined as the ratio of pulse pressure at the peaks of secondary to primary wave. Immediately before the radial pulse wave registration, an additional BP reading was obtained using the Omron 705CP oscillometric device.…”

Section: Examinations and Materialsmentioning

confidence: 99%

Mild hyperhomocysteinaemia is associated with increased aortic stiffness in general population

et al. 2006

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Total homocysteine (tHcy) level was identified as a strong and independent predictor of cardiovascular events. We investigated the association between tHcy and mechanical properties of large arteries in a random, general population-based sample of 251 subjects (mean age 48 years). Large artery properties, such as aortic and peripheral (lower-limb) pulse wave velocity (PWV), and augmentation index of radial artery were measured using semi-automatic Sphygmocor s device. Aortic PWV (APWV) positively correlated with tHcy (r ¼ 0.28, Po0.0001), and a significant increasing trend of APWV was found by tHcy quartiles (P ¼ 0.0003 by ANOVA). This association remained significant after adjustment for conventional cardiovascular risk factors (age, gender, smoking, overweight, hypertension, dyslipidaemia and impaired glucose metabolism) and for usual homocysteine confounders (folate, B 12 , renal function). Subjects with mild hyperhomocysteinaemia (i.e. with tHcy X15 lmol/l) had 2.74 times higher risk of having their APWV over 8.42 m/s (i.e. in the top quartile). No such association was found either for PWV measured at lower extremity or for radial augmentation index. In conclusion, in our series of subjects from general population, we found a strong and independent relationship between homocysteine concentration and APWV, a parameter of stiffness of central arteries.

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Large artery stiffness and pulse wave reflection: Results of a population‐based study

Cited by 47 publications

References 16 publications

The effect of smoking on arterial stiffness

The effect of smoking on arterial stiffness

Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffness

Mild hyperhomocysteinaemia is associated with increased aortic stiffness in general population

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