“…Pigs have been utilized in the exploration of neurological disorders due to their genetic, anatomical, and physiological similarities to humans. In the review by Han et al ( 2024a ), pigs, NHPs, and sheep were compared for their utility in studying HD, a monogenetic disorder with a genetic mutation that can be replicated across different species. Similar to mouse models of AD and PD, mouse models carrying the HD gene also fail to exhibit the robust and overt neurodegeneration observed in afflicted patient brains.…”