Abstract. For the nonlinear vibration response problems of aerospace thin-walled structures to thermalacoustic excitation, the theory of structural-acoustic coupling and the coupled FEM/BEM method were used to analyze dynamic response characteristics of super-alloy thin-walled rectangular plates with four edges clamped. Based on different loading ways: diffusion field, progressive wave 0°/ 45°/ 90°, the theories of buckling and snap-through were employed to study the stress/strain response of structures which were subjected to the different thermal-acoustic loading combinations. The majority of the analyses have dealt with the influence of acoustic loading ways and thermal loadings on structure stress/strain responses, the interaction mechanism of phenomenon of buckling and snap-through on stress/strain responses. Meanwhile, the experimental verifications of nature frequencies and strain have been done, respectively. The analysis results will provide a reference to determine a reasonable fatigue life prediction model.