Large-Amplitude Circadian Rhythm in Helper:suppressor Ratio of Peripheral Blood Lymphocytes

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

“…Moreover, a 12-h rhythm in both OKT8+ and HNK1+ lymphocytes was observed on 4 and 3 mo of study, respectively, including March, with similar rhythm characteristics. Of 15 reports in which circadian changes in the peripheral lymphocyte count are described, the season of study is only given in five (including three by us) (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(39)(40)(41)(42)(43). Ofthose, none was performed in March or in June.…”

“…Other discrepant reports pertained to the circadian rhythmicity in the T helper/T suppressor-cytotoxic ratio (20,21,23) and to that in phytohemagglutinin-induced lymphoblastic transformation in humans (19,22,24). This function test is known to primarily involve T lymphocytes.…”

“…A circadian rhythm in plasma luteinizing hormone was only found in the second half of the year in young men in two independent studies (27, 28). We hypothesized that the circadian time structure of the immune system would be subjected to a profound circannual modulation which would account for apparently discrepant results (16,23). The end points studied were the counts of circulating T and NK (29,30) lymphocyte subsets in healthy young men.…”

Effects of Prophylactic Thyroid Hormone Replacement in Euthyroid Hashimoto's Thyroiditis

“…Lymphocytic infiltration of the thyroid gland by equal number of B cells and cytotoxic T cells is a common histologic feature [4]. Studies evaluating peripheral and intrathyroidal lymphocytic populations from these patients revealed different results [5][6][7][8]. The effect of L-thyroxine (LT 4 ), which has been proven to modulate the immune process in animal models of spontaneous lymphocytic thyroditis animal models, is not clear when it comes to clinical studies especially for euthyroid patients for whom LT 4 therapy indication is controversial [9][10][11][12][13].…”

Viruses, Immunity, and Mental Disorders

“…Gender may also influence T-lymphocyte number: a fall in suppressor T cells may accompany acute relapse of multiple sclerosis in male but not female patients (Mingioli and McFarlin, 1984). Helper/suppressor ratios may manifest circadian rhythms (Levi et al, 1983). Serum (Rice et al, 1984), epinephrine (Crary et ai., 1983), immunosuppressive drugs [such as steroids (Hauser et al, 1983a)], and monoclonal problems themselves (Antel et al, 1982) may all modulate T-cell epitope expression.…”