Large airway constriction in allergic rhinitis: Response to inhalation of helium-oxygen

Fairshter, Ronald D.; Novey, Harold S.; Marchioli, Louis E.; Wilson, Archie F.

doi:10.1016/0091-6749(79)90160-x

Cited by 10 publications

(4 citation statements)

References 23 publications

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“… 36 Studies have reported the involvement of small or large airway constriction in patients with AR. 41 Therefore, a dilatory effect on pre-constricted airways is likely to bring about an improvement in patient symptomatology in AR. The effects of MP-AzeFlu on inflammatory markers such as cytokines and eosinophil survival have been studied through an in vitro model.…”

Section: Preclinical Evidencementioning

confidence: 99%

The Use of Azelastine Hydrochloride/Fluticasone Propionate in the Management of Allergic Rhinitis in Asia: A Review

Tantilipikorn,

Kirtsreesakul,

Bunnag

et al. 2024

JAA

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The incidence of allergic rhinitis (AR) in Asia and the world is steadily rising. Patients experience incomplete symptom relief despite existing treatment options, which warrants the need for new therapeutic regimes. Azelastine hydrochloride/fluticasone propionate (MP-AzeFlu), a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate has been indicated in the treatment of AR. The current review discusses the effects of MP-AzeFlu versus conventional therapies in achieving superior clinical improvement with a very rapid onset of action (5 minutes). The superiority of MP-AzeFlu in offering complete symptom control with sustained relief in patients with AR compared to the existing therapeutic options is also discussed. MP-AzeFlu has been shown to improve the quality of life for patients with AR, thereby enhancing patient adherence to therapy and establishing its preference for the treatment of AR. Currently, the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines recommend the use of a combination of intranasal corticosteroids and intranasal antihistamines as first-line treatment in patients with persistent AR with visual analog scores ≥5 or when prior treatment with single agents has been ineffective. Widely published data on the efficacy and safety of its prolonged use in adults and children have validated that effective treatment of AR can be achieved with MP-AzeFlu.

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Section: Preclinical Evidencementioning

confidence: 99%

The Use of Azelastine Hydrochloride/Fluticasone Propionate in the Management of Allergic Rhinitis in Asia: A Review

Tantilipikorn,

Kirtsreesakul,

Bunnag

et al. 2024

JAA

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“…Airflow obstruction in patients with allergic rhinitis was first reported more than 30 years ago. 2,3 However, relatively small numbers of subjects were included in these earlier studies. Ciprandi and Cirillo 1 report on 4782 subjects with allergic rhinitis without asthma symptoms and with a normal FEV 1 .…”

Section: Replymentioning

confidence: 99%

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Simon

Chinchilli

Phillips

et al. 2011

Journal of Allergy and Clinical Immunology

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“…2,3 However, relatively small numbers of subjects were included in these earlier studies. Airflow obstruction in patients with allergic rhinitis was first reported more than 30 years ago.…”

Section: Replymentioning

confidence: 99%