Large Adrenal Metastasis in Non-Small Cell Lung Carcinoma. Case                     Report and Literature Review

Charalambous, Stavros; Mylonaki, Efrosyni; Fotas, Asterios; Papatsoris, Athanasios; Παπαθανασίου, Αθανάσιος; Triantafyllidis, Argyrios; Rombis, V.; Touloupidis, Stravros

doi:10.1177/030089160809400125

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Adrenal metastasis are frequently reported, mainly related to lung and breast cancer, having been detected in up to 42% of patients with advanced non-small cell lung cancer 22 23. Adrenal insufficiency as a presenting manifestation of lung cancer is rare, as over 90% of the adrenal gland must be destroyed for the symptoms to develop 24.…”

Section: Discussionmentioning

confidence: 99%

Just another abdominal pain? Psoas abscess-likemetastasis in large cell lung cancer with adrenal insufficiency

Bernardino

Val-Flores²,

Dias

et al. 2015

BMJ Case Reports

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The authors report the case of a 69-year-old man with chronic obstructive pulmonary disease and previous pulmonary tuberculosis, who presented to the emergency department with abdominal and low back pain, anorexia and weight loss, rapidly evolving into shock. An initial CT scan revealed pulmonary condensation with associated cavitation and an iliopsoas mass suggestive of a psoas abscess. He was admitted in an intensive care unit unit; after a careful examination and laboratory assessment, the aetiology was yet undisclosed. MRI showed multiple retroperitoneal lymphadenopathies, bulky nodular adrenal lesions and bilateral iliac lytic lesions. Hypocortisolism was detected and treated with steroids. A CT-guided biopsy to the psoas mass and lytic lesions identified infiltration of non-small lung carcinoma. The patient died within days. Psoas metastases and adrenal insufficiency as initial manifestations of malignancy are rare and can be misdiagnosed, particularly in the absence of a known primary tumour.

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Section: Discussionmentioning

confidence: 99%

Just another abdominal pain? Psoas abscess-likemetastasis in large cell lung cancer with adrenal insufficiency

Bernardino

Val-Flores²,

Dias

et al. 2015

BMJ Case Reports

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“…[2] Adrenal metastases are usually solitary, diagnosed incidentally during staging and asymptomatic. [3] Bilateral adrenal metastases are rare, and often associated with diffuse systemic spread of the primary disease. [3,4] In advanced NSCLC, up to 40% of patients have metastatic adrenal gland involvement, however it is only apparent at the initial diagnosis in less than 10% of patients.…”

Section: Introductionmentioning

confidence: 99%

“…[3] Bilateral adrenal metastases are rare, and often associated with diffuse systemic spread of the primary disease. [3,4] In advanced NSCLC, up to 40% of patients have metastatic adrenal gland involvement, however it is only apparent at the initial diagnosis in less than 10% of patients. [5] In this report, we present a case of undiagnosed NSCLC manifesting as adrenal insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Adrenal insufficiency: an uncommon presentation of non-small cell lung cancer

Olayeye

Washington-Plaskett

Mbonu

et al. 2016

CRCP

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Metastasis to the adrenal gland has been observed in several malignancies; however, adrenal insufficiency as the presenting sign seems rare in these patients. This is a case of a patient presenting with nausea, vomiting, generalized fatigue, and hyponatremia. CT scan demonstrated left upper lobe opacity and bilateral adrenal masses. A biopsy of the adrenal gland revealed non-small cell lung cancer (NSCLC) with metastatic involvement of the adrenal glands. The non-specific symptoms and relative adrenal insufficiency in patients with lung masses should heighten the suspicion for metastatic involvement of the adrenals.

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Adrenal Insufficiency as a Presenting Manifestation of Nonsmall Cell Lung Cancer

Mohammad

Sadikot

2009

Southern Medical Journal

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The adrenals are a common site of metastases for lung cancers; adrenal insufficiency, however, as a presenting feature of lung cancer, is extremely rare. We report a case of primary adrenal insufficiency secondary to metastases from adenocarcinoma of the lung. Our patient presented with hypotension, abdominal pain, and weight loss. CT scans showed a right upper lobe mass and bilateral adrenal masses. The frequent occurrence of constitutional symptoms, metabolic derangements, and cardiovascular compromise in patients with advanced cancer may lead to an underestimation of the true incidence of adrenal insufficiency in this population.

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Large Adrenal Metastasis in Non-Small Cell Lung Carcinoma. Case Report and Literature Review

Cited by 3 publications

References 14 publications

Just another abdominal pain? Psoas abscess-likemetastasis in large cell lung cancer with adrenal insufficiency

Just another abdominal pain? Psoas abscess-likemetastasis in large cell lung cancer with adrenal insufficiency

Adrenal insufficiency: an uncommon presentation of non-small cell lung cancer

Adrenal Insufficiency as a Presenting Manifestation of Nonsmall Cell Lung Cancer

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