LAPONITE® nanodisk-“decorated” Fe<sub>3</sub>O<sub>4</sub> nanoparticles: a biocompatible nano-hybrid with ultrafast magnetic hyperthermia and MRI contrast agent ability

Basina, Georgia; Diamantopoulos, G.; Devlin, Eamonn; Psycharis, Vassilis; Alhassan, Saeed M.; Pissas, M.; Hadjipanayis, G. C.; Tomou, Aphrodite; Bouras, Alexandros; Hadjipanayis, Constantinos; Tzitzios, Vasileios

doi:10.1039/d2tb00139j

Cited by 5 publications

(2 citation statements)

References 85 publications

(176 reference statements)

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“…The development of these platforms expands the possibilities of nano-reagent research. [49][50][51][52] Future reviews will provide a detailed description of these promising diagnostic and therapeutic integrated nano-reagent platforms.…”

Section: Discussionmentioning

confidence: 99%

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Lai,

Luo,

Chen

et al. 2024

Science Progress

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X-ray computed tomography (CT) and magnetic resonance (MR) imaging are essential tools in modern medical diagnosis and treatment. However, traditional contrast agents are inadequate in the diagnosis of various health conditions. Consequently, the development of targeted nano-contrast agents has become a crucial area of focus in the development of medical image-enhancing contrast agents. To fully understand the current development of nano-contrast agents, this review provides an overview of the preparation methods and research advancements in CT nano-contrast agents, MR nano-contrast agents, and CT/MR multimodal nano-contrast agents described in previous publications. Due to the physicochemical properties of nanomaterials, such as self-assembly and surface modifiability, these specific nano-contrast agents can greatly improve the targeting of lesions through various preparation methods and clearly highlight the distinction between lesions and normal tissues in both CT and MR. As a result, they have the potential to be used in the early stages of disease to improve diagnostic capacity and level in medical imaging.

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Section: Discussionmentioning

confidence: 99%

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Lai,

Luo,

Chen

et al. 2024

Science Progress

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“…Basina et al [ 146 ] synthesised Fe 3 O 4 nanoparticles “decorated” with LAPONITE ® nanodisks, a synthetic clay with diamagnetic properties. The hybrids exhibited differing sizes, while the zeta potential varied in a Fe 3 O 4 -content-dependant fashion, decreasing as iron content increased.…”

Section: Treatmentmentioning

confidence: 99%

Highlighted Advances in Therapies for Difficult-To-Treat Brain Tumours Such as Glioblastoma

et al. 2023

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Glioblastoma multiforme (GBM) remains a challenging disease, as it is the most common and deadly brain tumour in adults and has no curative solution and an overall short survival time. This incurability and short survival time means that, despite its rarity (average incidence of 3.2 per 100,000 persons), there has been an increased effort to try to treat this disease. Standard of care in newly diagnosed glioblastoma is maximal tumour resection followed by initial concomitant radiotherapy and temozolomide (TMZ) and then further chemotherapy with TMZ. Imaging techniques are key not only to diagnose the extent of the affected tissue but also for surgery planning and even for intraoperative use. Eligible patients may combine TMZ with tumour treating fields (TTF) therapy, which delivers low-intensity and intermediate-frequency electric fields to arrest tumour growth. Nonetheless, the blood–brain barrier (BBB) and systemic side effects are obstacles to successful chemotherapy in GBM; thus, more targeted, custom therapies such as immunotherapy and nanotechnological drug delivery systems have been undergoing research with varying degrees of success. This review proposes an overview of the pathophysiology, possible treatments, and the most (not all) representative examples of the latest advancements.

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Smectite-supported metal nanoparticles: current trends and approaches

et al. 2023

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LAPONITE® nanodisk-“decorated” Fe₃O₄ nanoparticles: a biocompatible nano-hybrid with ultrafast magnetic hyperthermia and MRI contrast agent ability

Abstract: Magnetic Fe3O4 nanoparticles “decorated” by Laponite nanodisks have been materialized utilizing the Schikorr reaction following a facile approach; and tested as mediators of heat for the localized magnetic hyperthermia (MH)...

Cited by 5 publications

References 85 publications

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Highlighted Advances in Therapies for Difficult-To-Treat Brain Tumours Such as Glioblastoma

Smectite-supported metal nanoparticles: current trends and approaches

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LAPONITE® nanodisk-“decorated” Fe3O4 nanoparticles: a biocompatible nano-hybrid with ultrafast magnetic hyperthermia and MRI contrast agent ability

Abstract: Magnetic Fe3O4 nanoparticles “decorated” by Laponite nanodisks have been materialized utilizing the Schikorr reaction following a facile approach; and tested as mediators of heat for the localized magnetic hyperthermia (MH)...

Cited by 5 publications

References 85 publications

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Highlighted Advances in Therapies for Difficult-To-Treat Brain Tumours Such as Glioblastoma

Smectite-supported metal nanoparticles: current trends and approaches

Contact Info

Product

Resources

About

LAPONITE® nanodisk-“decorated” Fe₃O₄ nanoparticles: a biocompatible nano-hybrid with ultrafast magnetic hyperthermia and MRI contrast agent ability