Laponite nanoparticle-associated silated hydroxypropylmethyl cellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engineering

Boyer, Cinda M.; Figueiredo, Lara; Pace, Richard; Lesoeur, Julie; Rouillon, Thierry; Visage, Catherine Le; Tassin, Jean-François; Guicheux, Jérôme; Réthoré, Gildas

doi:10.1016/j.actbio.2017.11.027

Cited by 120 publications

(88 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydrogels are three-dimensional, cross-linked polymeric networks which possess an ability to swell in water without getting dissolved in it [3]. With the advantages of renewability, biocompatibility, biodegradability, and thermal and chemical stabilities, cellulose-based hydrogels can be used for wound healing [4], tissue engineering [5], and drug carrying [6].…”

Section: Introductionmentioning

confidence: 99%

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel

Zhang

Zhu

et al. 2019

Journal of Nanomaterials

View full text Add to dashboard Cite

A novel cellulose/TiO2/β-CD hydrogel with high photocatalytic antibacterial activity and sustained release of drug was prepared. TiO2 sol with a diameter of about 9 nm in this hydrogel was the photoantibacterial agent. β-CD can significantly enhance photoantibacterial activity and the sustained-release effect of this hydrogel. The structure and property of this hydrogel composite were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Escherichia coli and Staphylococcus aureus were selected as model bacteria to evaluate the antibacterial activity of the composite hydrogel under natural light irradiation and darkness, respectively. The in vitro release experiment used curcumin as a model drug in PBS buffer solution. The influence of β-CD on the antibacterial activity and sustained-release effect of the composite hydrogel was investigated. The results showed that the hydrogel composite presented a good photoantibacterial property, while the antibacterial activity can be neglected under the condition of no light. The complete release of curcumin from the composite was achieved after 120 h. Therefore, the hydrogel system has the characteristics of low cost and high effect, which could be used for an antibacterial sustained-release material.

show abstract

Section: Introductionmentioning

confidence: 99%

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel

Zhang

Zhu

et al. 2019

Journal of Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Moreover, previous studies have suggested that the mechanical properties of Si-HPMC remain far from those of native cartilage tissue. The stiffness of hydrogels is often reported has being two orders of magnitude lower than cartilage's (100-1000 kPa) (Levental et al, 2007;Boyer et al, 2018). These low mechanical properties have drastically limited their clinical translatability and hydrogels are mainly used as space-filling scaffolds used for the delivery of bioactive molecules and cells (Drury and Mooney, 2003;Kopeček, 2007).…”

Section: Discussionmentioning

confidence: 99%

A Self-Setting Hydrogel of Silylated Chitosan and Cellulose for the Repair of Osteochondral Defects: From in vitro Characterization to Preclinical Evaluation in Dogs

Boyer

Réthoré

Weiss

et al. 2020

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Articular cartilage (AC) may be affected by many injuries including traumatic lesions that predispose to osteoarthritis. Currently there is no efficient cure for cartilage lesions. In that respect, new strategies for regenerating AC are contemplated with interest. In this context, we aim to develop and characterize an injectable, self-hardening, mechanically reinforced hydrogel (Si-HPCH) composed of silanised hydroxypropymethyl cellulose (Si-HPMC) mixed with silanised chitosan. The in vitro cytocompatibility of Si-HPCH was tested using human adipose stromal cells (hASC). In vivo, we first mixed Si-HPCH with hASC to observe cell viability after implantation in nude mice subcutis. Si-HPCH associated or not with canine ASC (cASC), was then tested for the repair of osteochondral defects in canine femoral condyles. Our data demonstrated that Si-HPCH supports hASC viability in culture. Moreover, Si-HPCH allows the transplantation of hASC in the subcutis of nude mice while maintaining their viability and secretory activity. In the canine osteochondral defect model, while the empty defects were only partially filled with a fibrous tissue, defects filled with Si-HPCH with or without cASC, revealed a significant osteochondral regeneration. To conclude, Si-HPCH is an injectable, self-setting and cytocompatible hydrogel able to support the in vitro and in vivo viability and activity of hASC as well as the regeneration of osteochondral defects in dogs when implanted alone or with ASC.

show abstract

“…The nanocomposite hydrogel loaded with secretome provided a dual therapeutic system through its ability to promote angiogenesis and protect the heart, possessing the potential to improve the therapeutic efficacy of stem cellderived secretome for cardiac tissue repair and regeneration. Another strategy for tissue engineering is incorporated a small amount of laponites (XLG) with the silated hydroxypropylmethyl cellulose (Si-HPMC) hydrogel [97]. The prepared composite hydrogel led to the development of a hybrid interpenetrating network, improving the mechanical properties of the hydrogel.…”

Section: Silicate Clays For Biomedical Applicationsmentioning

confidence: 99%

Two-dimensional nanomaterials: fascinating materials in biomedical field

et al. 2019

View full text Add to dashboard Cite

Laponite nanoparticle-associated silated hydroxypropylmethyl cellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engineering

Cited by 120 publications

References 36 publications

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel

A Self-Setting Hydrogel of Silylated Chitosan and Cellulose for the Repair of Osteochondral Defects: From in vitro Characterization to Preclinical Evaluation in Dogs

Two-dimensional nanomaterials: fascinating materials in biomedical field

Contact Info

Product

Resources

About

Laponite nanoparticle-associated silated hydroxypropylmethyl cellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engineering

Cited by 120 publications

References 36 publications

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO2/β-CD Composite Hydrogel

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO2/β-CD Composite Hydrogel

A Self-Setting Hydrogel of Silylated Chitosan and Cellulose for the Repair of Osteochondral Defects: From in vitro Characterization to Preclinical Evaluation in Dogs

Two-dimensional nanomaterials: fascinating materials in biomedical field

Contact Info

Product

Resources

About

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel

Study on Photocatalytic Antibacterial and Sustained-Release Properties of Cellulose/TiO₂/β-CD Composite Hydrogel