Laponite–Gelatin Nanofibrous Microsphere Promoting Human Dental Follicle Stem Cells Attachment and Osteogenic Differentiation for Noninvasive Stem Cell Transplantation

Abstract

Back Cover: Nanofibrous architecture of 3‐dimensional scaffold can be an exceptional candidate for cell delivery. In article number 2200347, Jyotsnendu Giri and co‐workers fabricated the laponite loaded osteoinductive nanofibrous microspheres to mimic the native stem cell niche. Osteoinductive nanofibrous microspheres, facilitate the excellent stem cell attachment, proliferation, and osteogenic differentiation for noninvasive stem cell transplantation.

ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration

“…Scaffold materials are critical for optimizing bone tissue engineering. The microsphere scaffold with biomimicking nanostructure enable support excellent cell binding, metabolic activity, specific differentiations, and reconstruction of the stem cell niche [ 21 , 22 ]. To take complete advantage of the metabolic activity and microenvironmental regulation of ETV2, we fabricated HA/CS MS using microfluidic technology.…”

“…Microspheres are expected to reconstruct native stem cell niches, supporting the regulatory functions and metabolic activity of MSCs in the microenvironment [ 21 , 22 ]. We utilized hydroxyapatite/chitosan microspheres to deliver ETV2-DPSCs/MS complexes to critically sized rat cranial defect models, resulting in accelerated bone regeneration.…”