Lapine rotaviruses of the genotype P[22] are widespread in Italian rabbitries

Are Human P[14] Rotavirus Strains the Result of Interspecies Transmissions from Sheep or Other Ungulates That Belong to the Mammalian Order Artiodactyla ?

“…The P [14] genotype is also prevalent in rabbits (7,25), but the G3P [14] lapine rotavirus strain 30/96 and the human lapinelike G3P [14] rotavirus strain B4106 share only five to seven genotypes within the genomic constellation with the human and ungulate P [14] rotavirus strains investigated in this study, suggesting that lapine rotaviruses might have a distant evolutionary relationship with these nonlapine P [14] rotavirus strains. The VP2 gene segment of B4106 is a notable exception (Fig.…”

“…G12 might be the next important emerging strain, as it has been identified in sporadic cases and outbreaks in countries around the world (3, [6] in Africa or, more specifically, G8P [6] in Malawi and G5P [8] in Brazil, are regionally prevalent (1,10,29,47). Additional G types (G6, G8, G10, and G11) and P types ( [1], [3], [9], [10], [11], [14], [19], and [25]) have also been detected sporadically in humans (29,47). Many of these genotypes are believed to have originated from animal rotaviruses that were introduced into the human populations through interspecies transmission and/or gene reassortments, one of the major ways in which genetic rotavirus diversity is generated (12,27,29,43).…”

Frequent rearrangement may explain the structural heterogeneity in the 11th genome segment of lapine rotaviruses — Short communication

“…The nucleotide sequence of genome segment 11 of the two strains was determined by direct sequencing after amplification of the dsRNA by reverse transcription-PCR (Bányai et al, 2005;Martella et al, 2005). The alignment of genome segments 11 was prepared with the Multalin (Corpet, 1988) server and then manually adjusted using the GeneDoc software to obtain the best matches (Nicholas et al, 1997).…”

“…Such super-short Etype has been observed rarely in bovine (VMRI), porcine (MC345, CC86, CC117, C60) simian (YK-1) and human (69M, B37, B38, AU19, Z10262) strains (Paul et al, 1988;González et al, 1989;Nuttall et al, 1989;Scott et al, 1989;Mattion et al, 1990;Ciarlet et al, 1997;Palombo et al, 1998;Nakagomi et al, 1999;Westerman et al, 2006). In addition, super-short RNA profile has been observed frequently in lapine rotaviruses (ALA, BAPwt, BAP-2, 3489/3, LRV-4; Thouless et al, 1986;Tanaka et al, 1988;Bányai et al, 2005;Martella et al, 2005) and in a lapine-like human strain, B4106, detected in Belgium (De Leener et al, 2004;Matthijnssens et al, 2006a). In addition, some tissue-culture adapted lapine rotavirus (LRV) strains has atypical long genome pattern (strain C-11) due to abnormal mobility of genome segment 10 or a short pattern (strain R-2) due to slower migration of genome segment 11 (Thouless et al, 1986).…”

Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain

“…After the original identification of the P11 [14] VP4 type in HRV strains isolated in Italy and Finland [55], characterization of lapine rotavirus has also revealed that P11 [14]G3 are a common P/G combination in rotaviruses of rabbits [21,30,56]. Although the VP4 of the P11 [14] lapine and HRV strains may have a common origin, it was always speculated that the HRV P11 [14] strains are naturally occurring reassortants between humans and cattle [30].…”