Laparoscopic Versus Open Surgery for Rectal Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Zhang, Fengwa; Zhou, Zhao-Yu; Wang, Hailin; Zhang, Jv-Xia; Di, Baoshan; Huang, Wenhui; Yang, Kehu

doi:10.7314/apjcp.2014.15.22.9985

Cited by 37 publications

(27 citation statements)

References 45 publications

(181 reference statements)

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“…The mortality, recurrence, and survival were no different between open and laparoscopic surgery . Similarly, an earlier systematic review and meta‐analysis of RCTs showed fewer complications and lower LOS for laparoscopic surgery and, again, no significant difference in recurrence and survival rates between open and laparoscopic surgery for rectal cancer . However, one systematic review and meta‐analysis published in 2013 suggested lower mortality and morbidity (RR 0.46 and 0.83, respectively) for laparoscopic surgery for rectal cancer .…”

Section: Discussionmentioning

confidence: 84%

Comparison of outcome and cost among open, laparoscopic, and robotic surgical treatments for rectal cancer: A propensity score matched analysis of nationwide inpatient sample data

Chen

Hsu

et al. 2017

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 84%

Comparison of outcome and cost among open, laparoscopic, and robotic surgical treatments for rectal cancer: A propensity score matched analysis of nationwide inpatient sample data

Chen

Hsu

et al. 2017

Journal of Surgical Oncology

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“…The main treatment options for CRC include surgery, chemotherapy and radiotherapy . While surgical resection is associated with anastomotic leakage, postoperative intestinal obstruction, urinary retention and deep venous thrombosis, radiotherapy can cause serious side‐effects such as fecal incontinence, sexual dysfunction and secondary malignancies . In addition, the occurrence of chemo‐resistance and serve toxic side effects also limited the clinical utility of chemotherapeutic drugs .…”

Section: Introductionmentioning

confidence: 99%

Chrysophanol exhibits inhibitory activities against colorectal cancer by targeting decorin

Deng

Xue

et al. 2019

Cell Biochemistry & Function

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Colorectal cancer (CRC) is a common human malignancy that accounts for 600,000 deaths annually worldwide. Chrysophanol, a naturally occurring anthraquinone compound, exhibits anti-neoplastic effects in various cancer cells. The aim of this study was to explore the biological effects of chrysophanol on CRC cells, and determine the underlying mechanism. Chrysophanol inhibited proliferation of and promoted apoptosis in CRC cells by activating the intrinsic mitochondrial apoptotic pathway.In addition, chrysophanol also suppressed tumor growth in vivo and increased the percentage of apoptotic cells in tumor xenografts, without general toxicity. Proteomic iTRAQ analysis revealed decorin (DCN) as the major target of chrysophanol. DCN was upregulated in the tumor tissues following chrysophanol treatment, and ectopic DCN expression markedly augmented the pro-apoptotic effects of chrysophanol in CRC cells. In contrast, DCN knockdown significantly abrogated chrysophanolinduced apoptosis in CRC cells. Taken together, chrysophanol exerts anti-neoplastic effects in vitro and in vivo in CRC cells by modulating DCN, there by highlighting its therapeutic potential in CRC.

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“…Compared with open surgery, it has similar short1 and long-term2–5 outcomes, but with more clinical advantages, such as less blood loss and postoperative pain, faster recovery, and less hospital stay time 1,6,7. Laparoscopic surgery enables the shortening of time to initiate chemotherapy in colorectal cancer patients following surgery 8…”

mentioning

confidence: 99%

Factors Influencing Difficulty of Laparoscopic Abdominoperineal Resection for Ultra-Low Rectal Cancer

Jiang

et al. 2017

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Purpose:Our current study was conducted to identify patients’ anatomic, pathologic, and clinical factors to predict difficulty of performing laparoscopic abdominoperineal resection for ultra-low rectal cancer.Materials and Methods:Records of 117 consecutive patients with rectal cancer 2 to 5 cm from the anal verge were retrospectively reviewed. Using univariate and multivariate linear or logistic regression models, standardized operative time and blood loss, as well as postoperative morbidity were utilized as endpoints to screen patients’ multiple variables to predict operative difficulty.Results:Multivariate linear regression analysis showed body mass index (BMI) (estimate=0.07, P=0.0056), interspinous distance (estimate=−0.02, P=0.0011), tumor distance from anal verge (estimate=−0.17, P=0.0355), prior abdominal surgery (estimate=0.51, P=0.0180), preoperative chemoradiotherapy (estimate=0.67, P=0.0146), and concurrent diseases (hypertension and/or diabetes mellitus) (estimate=0.49, P=0.0122) are predictors for standardized operative time. Age (estimate=0.02, P=0.0208) and concurrent diseases (estimate=0.43, P=0.0476) were factors related to standardized blood loss. BMI (estimate=0.15, P=0.0472) was the only predictor for postoperative morbidity based on logistic regression analysis.Conclusions:Age, BMI, interspinous distance, tumor distance from anal verge, prior abdominal surgery, preoperative chemoradiotherapy, and concurrent diseases influence the difficulty of performing laparoscopic abdominoperineal resection for ultra-low rectal cancer. Standardized operative time allows researchers to amass samples by pooling data from all published studies, thus building reliable models to predict operative difficulty for clinical use.

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Laparoscopic Versus Open Surgery for Rectal Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Cited by 37 publications

References 45 publications

Comparison of outcome and cost among open, laparoscopic, and robotic surgical treatments for rectal cancer: A propensity score matched analysis of nationwide inpatient sample data

Comparison of outcome and cost among open, laparoscopic, and robotic surgical treatments for rectal cancer: A propensity score matched analysis of nationwide inpatient sample data

Chrysophanol exhibits inhibitory activities against colorectal cancer by targeting decorin

Factors Influencing Difficulty of Laparoscopic Abdominoperineal Resection for Ultra-Low Rectal Cancer

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