“…We suggest classifying the predictor factors of VPS failure into two groups: CSF-related disorders and abdominal-related conditions. Indeed, CSF with a high protein concentration, speci cally caused by opticchiasmal hypothalamic glioma [8, 15,17,24], craniopharyngioma [10], plasminogene de ciency [11] and tuberculosis [7,17] may be subject for proteinaceous ascites and therefore VPS failure.In these cases, the gallbladder is an e cient receptacle: CSF will be excreted and then absorbed in the intestinal tract. Nevertheless, the lytic action of bile may catabolize brinous adhesion around the distal shunt tip CSF [7,15,17,22].…”