Laparoscopic Total Pancreatectomy With Islet Autotransplantation and Intraoperative Islet Separation as a Treatment for Patients With Chronic Pancreatitis

Fan, Caleb J.; Hirose, Kenzo; Walsh, Christi; Quartuccio, Michael; Desai, Niraj M.; Singh, Vikesh K.; Kalyani, Rita R.; Warren, Daniel; Sun, Zhaoli; Hanna, Marie N.; Makary, Martin A.

doi:10.1001/jamasurg.2016.5707

Cited by 40 publications

(27 citation statements)

References 35 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ 12 ] No 30-days surgery related mortality after LTP was reported in the literature. Some surgeons may dissect the pancreatic neck during LTP, [ 11 , 28 ] dividing the LTP into 2 independent procedures: laparoscopic pancreaticoduodenectomy and laparoscopic distal pancreatectomy. This maneuver might facilitate the LTP, however, it violated the principle of en-bloc resection, especially in setting of diffuse malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

A novel surgical approach for en-bloc resection laparoscopic total pancreatectomy

Cai

Gao²,

Peng

2020

Medicine

View full text Add to dashboard Cite

Laparoscopic total pancreatectomy (LTP) is technical challenging and rarely reported in the literature. Herein, we introduced a safe and feasible approach to perform LTP basing on our own experience. Over the period of July 2015 to August 2018, we performed 13 cases of LTP at our institution. Demographic characteristics, intraoperative and postoperative variables, and follow-up outcomes were prospectively collected. The surgical procedures were also described in this study. Seven male and six female patients were included in this study. The median age of the patients was 51 years (range 29–79 years). The median operative time was 355 minutes (range 300–470 minutes). The median estimated blood loss was 200 mL (range 50–1000 mL). The median postoperative hospital stay was 17 days (range 12–23 days). One patient suffered from bile leakage and another patient suffered from delayed gastric emptying. Both patients cured with conservative therapy. Laparoscopic total pancreatectomy can be safely and feasibly performed in well-selected patients.

show abstract

Section: Discussionmentioning

confidence: 99%

A novel surgical approach for en-bloc resection laparoscopic total pancreatectomy

Cai

Gao²,

Peng

2020

Medicine

View full text Add to dashboard Cite

show abstract

“…Количество подобных оперативных вмешательств в последнее время имеет стойкую тенденцию к увеличению [57][58][59]. Абсолютное большинство центров демонстрируют нулевую летальность после операции, при общем анализе она не превышает 1% [60,61]. Результаты подобных вмешательств оцениваются на основании изменения качества жизни: исчезновения болевого синдрома и снижения потребности в опиоидах, профилактике гипогликемий.…”

Section: аутотрансплантация клеток островкового аппарата при хроничесunclassified

“…Этот эффект может сохраняться длительное время. Примерно 73% пациентов сохраняют независимость от анальгетиков более 5 лет [60].…”

Section: аутотрансплантация клеток островкового аппарата при хроничесunclassified

Transplantation technologies for treatment of carbohydrate metabolism disorders

Загайнов¹,

Meleshina

Korneva

et al. 2020

RJTAO

View full text Add to dashboard Cite

The review includes results of retrospective and prospective clinical studies (foreign and national) and guidelines on the use of transplantation technologies for treatment of type 1 diabetes and pancreatogenic diabetes in chronic pancreatitis and pancreatic conditions. Modern data on prevalence of diabetes and modern insulin delivery methods are presented. Results of transplantation of pancreas and islets of Langerhans in primary insulin-dependent conditions are considered. Analysis of the technology for isolation and autotransplantation of islets after pancreatectomy in chronic pancreatitis and benign tumor diseases are given.

show abstract

“…Total pancreatectomy serves as an opportunity to alleviate chronic abdominal pain and reduce opiate usage. Published rates of successful withdrawal of opiates following total pancreatectomy vary (Table 1) [79][80][81][82][83][84][85][86]. The highest rates are observed in the younger patient cohort [87].…”

Section: Surgical Managementmentioning

confidence: 99%

Hereditary Pancreatitis – A Review of Current Concepts and Management

Hughes¹,

Gordon-Weeks²,

Silva³

2019

obm hg

View full text Add to dashboard Cite

Background: Hereditary Pancreatitis is a rare cause of acute pancreatitis. These patients usually present at a young age with recurrent episodes of acute pancreatitis that usually progresses to chronic pancreatitis with associated endocrine and exocrine failure. Hereditary pancreatitis also carries an increased lifetime risk of pancreatic adenocarcinoma. These high risk patients need early intervention where appropriate by specialist multidisciplinary teams and tailored long term management. Methods: A review of the relevant literature regarding the epidemiology, the genetic mechanisms responsible for the disease and current management strategies for Hereditary Pancreatitis was performed. Results: Several underlying genetic driver mutations for Hereditary Pancreatitis have been identified, notably PRSS1, SPINK1, CFTR and CRTC mutations. Recurrent episodes of pancreatitis result in a progressive loss of normal pancreatic parenchyma, which is

show abstract

Laparoscopic Total Pancreatectomy With Islet Autotransplantation and Intraoperative Islet Separation as a Treatment for Patients With Chronic Pancreatitis

Abstract: This study represents the first series of L-TPIAT, demonstrating its safety and feasibility. Our approach enables patients to experience shorter operative times and the benefits of laparoscopy, including reduced length of stay and quicker opioid independence.

Cited by 40 publications

References 35 publications

A novel surgical approach for en-bloc resection laparoscopic total pancreatectomy

A novel surgical approach for en-bloc resection laparoscopic total pancreatectomy

Transplantation technologies for treatment of carbohydrate metabolism disorders

Hereditary Pancreatitis – A Review of Current Concepts and Management

Contact Info

Product

Resources

About