Laparoscopic surgery in the rat Beneficial effect on body weight and tumor take

Bouvy, Nicole D.; Rl, Marquet; Hamming, J. F.; Jeekel, J.; Bonjer, H. J.

doi:10.1007/s004649910096

Cited by 38 publications

(58 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Jacobi et al 32 showed that the simple act of creating a CO 2 pneumoperitoneum caused increased tumor growth within the peritoneal cavity. Work by Bouvy et al 33,34 using both cell suspension and solid tumor models achieved similar results. In contrast, the results of Hubens and Eyskens 35 showed no difference in the rate intraperitoneal tumor growth between anesthetic controls and CO 2 insufflation.…”

Section: Discussionmentioning

confidence: 61%

“…38 However, studies generally demonstrate that this effect is less with laparoscopy. [32][33][34][35]39 These studies have examined the effects of laparoscopy on tumor growth at a site remote from the peritoneal cavity, such as the animal's flank, and may help to explain some of the differences between their findings and our study.…”

Section: Discussionmentioning

confidence: 90%

“…Bouvy et al 33 also investigated the effects of gasless laparoscopy on intraperitoneal tumor growth with use of a solid tumor model and showed that both laparotomy and CO 2 pneumoperitoneum produced significantly greater intraperitoneal tumor growth than gasless laparoscopy did. Portsite metastases were also significantly reduced in the gasless group compared with the CO 2 pneumoperitoneum group.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model

Dorrance

Oien

O’Dwyer

1999

Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model

Dorrance

Oien

O’Dwyer

1999

Surgery

View full text Add to dashboard Cite

“…4,5 Previously described clinical and experimental studies showed that surgical trauma promotes intra-abdominal tumor recurrence. [6][7][8] In an animal experimental study Raa et al 9 showed that this effect is mainly due to enhanced adhesion of tumor cells rather than enhanced growth of already adhered tumor cell clusters.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Reactive Oxygen Species on the Adhesion of Pancreatic Carcinoma Cells to the Peritoneum

Raa

Grevenstein

Kate

et al. 2007

Cell Adhesion & Migration

View full text Add to dashboard Cite

Postoperative peritoneal carcinomatosis is a significant clinical problem after "curative" resection of pancreatic carcinoma. Preoperative surgical trauma activates a cascade of peritoneal defense mechanisms responsible for postoperative intra-abdominal tumor recurrence. Reactive oxygen species (ROS) play a pivotal role in this postoperative inflammatory reaction. This study explores the influence of ROS on adhesion of human pancreatic carcinoma cells to human mesothelial cells. Furthermore this study explores the influence of ROS on the presentation of adhesion molecules on Panc-1 and mesothelial cells. ROS were produced using the enzymatic reaction of xanthine with xanthine oxidase (X/XO). A reproducible in vitro assay to study adhesion of human Panc-1 carcinoma tumor cells to a mesothelial cell monolayer of primary human mesothelial cells was used. Mesothelial monolayers were incubated with ROS produced prior to adhesion of the tumor cells. Incubation of the mesothelial cells with X/XO resulted in a significant increase (69.5%) in adhesion of Panc-1 in all patients. SOD/catalase, anti-oxidants, could reduce this increase by 56.7%. ROS significantly influenced the expression of the adhesion molecules ICAM-1, VCAM-1 and CD44h on mesothelial cells, but did not influence adhesion molecule expression on Panc-1. The ROS released during the post-operative inflammatory reaction may play an important role in the adhesion of pancreatic tumor cells to the mesothelium-possibly by influencing adhesion molecule expression on mesothelial cells. Therefore ROS can partly be responsible for the enhanced post-operative intra-abdominal tumor recurrence.

show abstract

“…Bouvy et al [2], who have provided some helpful insights into the behavior of malignant tumor cells during laparoscopic surgery. As with work previously reported by Allendorf et al [1], they have demonstrated that laparoscopic procedures may be associated with reduced growth of tumor cells in a smallanimal model.…”

mentioning

confidence: 99%

Laparoscopic surgery in the rat

Watson

Mathew

1997

Surg Endosc

View full text Add to dashboard Cite

We read with interest the paper from Drs. Bouvy et al. [2], who have provided some helpful insights into the behavior of malignant tumor cells during laparoscopic surgery. As with work previously reported by Allendorf et al. [1], they have demonstrated that laparoscopic procedures may be associated with reduced growth of tumor cells in a smallanimal model. This may be due to reduced physiological stress in animals undergoing laparoscopic surgery, resulting in less perioperative suppression of the immune system. However, we would caution readers not to draw the conclusion that laparoscopic approaches to the resection of abdominal malignancy are safe. In Dr. Bouvy's study, cancer cells were not introduced into the peritoneal cavity until after the surgical procedure was concluded. Therefore the potential for cancer cells to be redistributed by the insufflation of C0 2 gas and cause wound metastases was not tested.Our own recent experience [ 4] with laparoscopic and open surgical laceration of an implanted adenocarcinoma in a rat model has demonstrated a fivefold increase in the incidence of metastases in the abdominal access wounds of rats undergoing laparoscopic surgery despite the advantage of reduced growth of the implanted' 'primary'' tumor. Similar results have been reported by Jones et al. [3] following the introduction of free tumor cells into the abdominal cavity at the commencement of either laparoscopy with C0 2 insufflation or laparotomy in a hamster model. These studies suggest that if cancer cells are liberated during prolonged C0 2 insufflation, metastatic implantation and growth in abdominal wall wounds is more common following laparoscopic surgery. Interestingly, a further experiment using the same implanted tumor model in our institution during laparoscopic tumor laceration at both gasless and conventional laparoscopy demonstrated a threefold reduction in the incidence of wound metastases following gasless laparoscopy (unpublished data).It would be interesting to repeat the experiments per-

show abstract

Laparoscopic surgery in the rat Beneficial effect on body weight and tumor take

Abstract: Laparoscopic surgery is associated with less postoperative weight loss and less tumor take compared to open surgery. CO2 insufflation appears to increase tumor take.

Cited by 38 publications

References 0 publications

Effects of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model

Effects of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model

The Influence of Reactive Oxygen Species on the Adhesion of Pancreatic Carcinoma Cells to the Peritoneum

Laparoscopic surgery in the rat

Contact Info

Product

Resources

About