Laparoscopic sleeve gastrectomy in adult and pediatric obese patients: a comparative study

Alqahtani, Aayed R.; Alamri, Hussam; Elahmedi, Mohamed; Mohammed, Rafiuddin

doi:10.1007/s00464-012-2345-x

Cited by 65 publications

(37 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been previously reported that children and adolescents who undergo laparoscopic sleeve gastrectomy (LSG) experience well-tolerated, effective, and sustained reduction of body weight, with resolution of the majority of their co-morbidities [7][8][9]. However, offering bariatric surgery to patients with syndromic forms of obesity, let alone PWS, is still controversial [10].…”

mentioning

confidence: 98%

See 1 more Smart Citation

Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study

Alqahtani

Elahmedi

Qahtani

et al. 2016

Surgery for Obesity and Related Diseases

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 98%

“…[2][3][4][5][6][7][8][9][10][11][12][13]. This syndrome has an estimated prevalence ranging from 1 in 8,000 to 1 in 50,000 individuals.…”

mentioning

confidence: 99%

Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study

Alqahtani

Elahmedi

Qahtani

et al. 2016

Surgery for Obesity and Related Diseases

View full text Add to dashboard Cite

show abstract

“…This technique involves the removal of a large portion of the stomach through a vertical resection, and the remaining stomach has a volume drastically reduced, with a capacity of around 100/150 ml. Weight loss outcomes in some study were similar between pediatric and adult patients at all time points, suggesting that LSG is similarly safe and effective in young and adult patients through at least 1 year of follow-up [192].…”

Section: Treatment Options In Patients With Genetic Obesitymentioning

confidence: 79%

New Thoughts on Pediatric Genetic Obesity: Pathogenesis, Clinical Characteristics and Treatment Approach

Stagi¹,

Bianconi²,

Sammarco³

et al. 2017

Adiposity - Omics and Molecular Understanding

View full text Add to dashboard Cite

Historically, some genetic syndromes and monogenic forms of obesity have been identified by clinical features and by sequencing candidate genes in patients with severe obesity. The phenotypic expression of genetic factors involved in obesity is variable, thereby allowing to distinguish several clinical pictures of obesity. Monogenic obesity is described as rare and severe early-onset obesity with abnormal feeding behavior and endocrine disorders. Many of the findings emerged from studying families who displayed a classical Mendelian pattern of inheritance. On the contrary, patients with syndromic obesity show a various degree of intellectual disability, different dysmorphic features, and organ-specific abnormalities. But to date, not all involved genes have been identified so far. New diagnostic tools, such as genome-wide studies, array CGH, and whole-exome sequencing, have highlighted more complex models of inheritance, and even more candidate genes were identified. This increase of knowledge may provide insights into the mechanisms involved in the regulation of body weight and finally lead to specific treatments. In these patients, hyperphagia is often a primary phenotypic component. Substantial gaps in understanding the molecular basis of inherited hyperphagia syndromes are present today with a lack of mechanistic targets that can serve as a basis for pharmacologic and behavioral treatments. We have evaluated retrospectively the literature data on weight, body mass index (BMI), clinical features, treatments, and treatment response in pediatric patients with forms of genetic obesity. However, this chapter provides an updated picture of emerging knowledge outlined by the more comprehensive genetic approaches, trying to outline more candidate genes for these forms of genetic obesity. Relevant papers will be identified through systematic searches of the PubMed, EMBASE and Cochrane databases. All published studies in the English language concerning these disorders will be evaluated. Keywords in the

show abstract

“…Bariatric surgery is the only effective intervention to achieve substantial long-term weight loss and improvement of comorbidities 1,2 in adults. With the increasing prevalence of childhood and adolescent obesity [3][4][5] and their related health risks both at current age [6][7][8] as well as later in life, 4,9 early treatment is of major importance and morbidly obese adolescents are increasingly being considered for bariatric surgery. However, there is controversy regarding the ethics of bariatric surgery in adolescents, with questions on long-term safety and effectiveness of bariatric surgery in adolescents remaining unanswered.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic Sleeve Gastrectomy versus Gastric Bypass in Late Adolescents: What Is the Optimal Surgical Strategy for Morbid Obesity?

et al. 2016

View full text Add to dashboard Cite

Interest in bariatric surgery in adolescents is increasing, because adolescent obesity equals increased health risks in adult life. To define the preferred procedure in adolescents, this study compares outcomes of LSG and LRYGB in late adolescents in our center. Data on baseline characteristics, operative details, and follow-up were collected retrospectively in all patients (age 18-20 years) who underwent LSG or LRYGB in our clinic. Outcomes were analyzed using nonparametric tests. Total 65 adolescents (54 females; median age 19 years) were included, 45 patients underwent LSG, and 20 underwent LRYGB.Significant differences in %EWL were observed at 2-year follow-up; 81.0% in LRYGB ( = 11) versus 96.8% in LSG ( = 23), = 0.007. No differences were observed in postoperative mortality, complication rate, and resolution of comorbidities between both procedures. LSG showed significant better results than LRYGB in terms of %EWL after 2 years in this selected group of late adolescents. Considering these results in LSG patients and the theoretical advantages of LSG (normal diet options, preservation of an intact GI-tract, less vitamin disturbances, and better quality of life), LSG may be an appropriate bariatric technique to perform in morbidly obese adolescents.

show abstract

Laparoscopic sleeve gastrectomy in adult and pediatric obese patients: a comparative study

Cited by 65 publications

References 39 publications

Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study

Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study

New Thoughts on Pediatric Genetic Obesity: Pathogenesis, Clinical Characteristics and Treatment Approach

Laparoscopic Sleeve Gastrectomy versus Gastric Bypass in Late Adolescents: What Is the Optimal Surgical Strategy for Morbid Obesity?

Contact Info

Product

Resources

About