Laparoscopic sleeve gastrectomy for diabetes treatment in nonmorbidly obese patients: Efficacy and change of insulin secretion

Lee, Wei-Jei; Ser, Kong-Han; Chong, Keong; Lee, Yi-Chih; Chen, Shuchun; Tsou, Ju-Juin; Chen, Jung-Chien; Chen, Chih‐Ming

doi:10.1016/j.surg.2009.10.059

Cited by 153 publications

(96 citation statements)

References 34 publications

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“…Studies reported that the Asian populations with type II diabetes and non-morbid obesity (BMI, 25-35 kg/m 2 ), sleeve gastrectomy has demonstrated up to 50% remission in diabetes at 1 year [27] and our study show remission of DM in 90% at the first year and almost all patients at 2 years.…”

Section: Discussionsupporting

confidence: 67%

Metabolic Improvement in Blood Glucose and Cholesterol after Sleeve Gastroectomy

Al-zobaydi¹,

Alkarak²,

Sharif³

et al. 2017

J Obes Weight Loss Ther

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Objective: To investigate the long-term effects of laparoscopic sleeve gastrectomy on weight loss, blood sugar and cholesterol. Materials & Methods:A total of 306 morbidly obese patients who underwent laparoscopic sleeve gastrectomy over three years from 2014-02-2017 at King Khalid Hospital Obesity Center, Najran (Saudi Arabia ) monitored postoperatively for a periodically over 24 months duration for weight reduction and metabolic changes by measurement of BMI, total body cholesterol and fasting blood sugar lower than 126 mg/(5.6-7 mmol). Hypercholesterolemia was defined as a total cholesterol level higher than 240 mg/dl (6.2 mmol), total cholesterol 200-240 mg/dl (5.2-6.2 mmol) considered as borderline, and less than 200 mg/dl (5.2 mmol) is normal. Result:The percentage of excess body weight was 50.8% (68 kh) and the percentage of excess weight loss was 18%, 34%, 55.6% and 73% at 3, 6, 12 and 24 months respectively and this excess weight loss was significant with P value less than 0.00001 and T value of 9.08. Blood sugar was significantly improved from preoperative 6 mmol to postoperative 5.75, 5.3, 5 and 4.3 mmol at 3, 6, 12 and 24 month respectively and this improvement was statistically significant as calculated using both T calculator for two dependent mean and the f-ratio value both yield P-value is <0.00001 which is statistically significant at p<0.01 and continue follow up for the mean blood sugar was normalized (4.3 mmol) which also statistically significant. Total body cholesterol was decreased from mean preoperative 5.6 mmol to 5.24, 5.2, 2, 4.97 and 4.3 mmol in 3, 6, 12, 24 months respectively and this reduction was statistically significant at P-value less than 0.01. Conclusion:Sleeve gastrectomy is a safe and effective bariatric procedure with approximately 75% of the excessive weight loss achieved at the first two-years, normalized blood sugar occurs in 96% of patients with normalization of total body cholesterol in all with satisfactory long-term results regarding weight loss and comorbidities.

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Section: Discussionsupporting

confidence: 67%

Metabolic Improvement in Blood Glucose and Cholesterol after Sleeve Gastroectomy

Al-zobaydi¹,

Alkarak²,

Sharif³

et al. 2017

J Obes Weight Loss Ther

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“…-Patients with BMI ≥ 30 and < 35 kg/m 2 with T2DM may be considered for bariatric surgery on an individual basis, as there is evidence-based data supporting bariatric surgery benefits in regards to T2DM remission or improvement (EL A, B, C, D [48][49][50][51][52][53][54][55][56][57][58][59][60] ). However there is not yet available large enough number of high evidence level data to unquestionably support a clear, long-term benefit, especially for merely and self-standing surgical treatment/control of glycaemia, dyslipidaemia and/or other metabolic diseases.…”

Section: Bariatric Surgery and T2dmmentioning

confidence: 99%

Interdisciplinary European guidelines on metabolic and bariatric surgery

Fried

Yumuk

Jm³

et al. 2017

Gastroent Hepatol

147

207

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In 2012, an outstanding expert panel derived from IFSO-EC (International Federation for the Surgery of Obesity -European Chapter) and EASO (European Association for the Study of Obesity), composed by key representatives of both Societies including past and present presidents together with EASO's OMTF (Obesity Management Task Force) chair, agreed to devote the joint Medico-Surgical Workshop of both institutions to the topic of metabolic surgery as a pre-satellite of the 2013 European Congress on Obesity (ECO) to be held in Liverpool given the extraordinarily advancement made specifically in this field during the past years. It was further agreed to revise and update the 2008 Interdisciplinary European Guidelines on Surgery of Severe Obesity produced in cooperation of both Societies by focusing in particular on the evidence gathered in relation to the effects on diabetes during this lustrum and the subsequent changes that have taken place in patient eligibility criteria. The expert panel composition allowed the coverage of key disciplines in the comprehensive management of obesity and obesity-associated diseases, aimed specifically at updating the clinical guidelines to reflect current knowledge, expertise and evidence-based data on metabolic and bariatric surgery.

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“…Hyperglycemia following the meal is the main stimulus for insulinsecretion. [27] Other factors that promote insulin synthesis and secretion are some amino acids such as alanine, glycine, arginine; vagal nerve (acetyl choline), incretins [GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)]. [27] It has many actions related to energy balance.…”

Section: Insulinmentioning

confidence: 99%

“…[27] Other factors that promote insulin synthesis and secretion are some amino acids such as alanine, glycine, arginine; vagal nerve (acetyl choline), incretins [GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)]. [27] It has many actions related to energy balance. Postprandial spikes of insulin result in glycogen storage in tissues such as muscle and liver and also triglycerides in the adipose tissues.…”

Section: Insulinmentioning

confidence: 99%

Physiologic changes in obesity and patient preparation for bariatric surgery

Şahin¹

2017

Laparosc Endosc Surg Sci

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Morbid obesity is pandemic. Regardless of the socioeconomic status of the population, incidence of obesity is increasing worldwide. Bariatric surgery provides the only stable means of surgical cure for obesity. Number of bariatric procedures performed is increasing around the world. Morbidly obese patients are physiologically prone to complications after such major surgery. In the present review, the mechanisms of obesity and altered organ systems were discussed, and a brief summary of key points in preoperative patient evaluation was explained.

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Laparoscopic sleeve gastrectomy for diabetes treatment in nonmorbidly obese patients: Efficacy and change of insulin secretion

Cited by 153 publications

References 34 publications

Metabolic Improvement in Blood Glucose and Cholesterol after Sleeve Gastroectomy

Metabolic Improvement in Blood Glucose and Cholesterol after Sleeve Gastroectomy

Interdisciplinary European guidelines on metabolic and bariatric surgery

Physiologic changes in obesity and patient preparation for bariatric surgery

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