Laparoscopic sentinel lymph node procedure using a combination of patent blue and radioisotope in women with cervical carcinoma

Barranger, Emmanuel; Grahek, D.; Cortez, Annie; Talbot, J.-N.; Uzan, Serge; Daraı̈, Émile

doi:10.1002/cncr.11423

Cited by 89 publications

(40 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SN procedure. SN procedure was performed in accordance with previous studies using combined radiocolloid and colorimetric technique [7,9,12,13]. The position of each SN relative to the major pelvic vessels, and the count rate, were recorded.…”

Section: Patients and Methods Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Coutant¹,

Barranger²,

Cortez

et al. 2007

Annals of Oncology

View full text Add to dashboard Cite

Background: It has been suggested that histologically undetectable or 'occult' metastases in the lymphatic system could explain some recurrences. HPV DNA screening by means of the polymerase chain reaction (PCR) has been proposed as a method to detect occult metastases. This study was designed to determine the frequency of HPV DNA detection by PCR in sentinel lymph node (SN), and its relation to the clinical characteristics and outcome of women with cervical cancer. Patients and methods:The primary cervical tumor and SN were tested for HPV DNA by means of PCR in 59 patients.Results: Fifteen (25.4%) of the 59 women undergoing the SN procedure had an involved SN. HPV DNA was more frequent in positive SN than in negative SN (P < 0.0001). Seven patients had a recurrence, after a mean delay of 17 months (range: 10-26). One of seven patients with a recurrence had an involved SN. HPV DNA was detected in an SN of one of seven patients with recurrence and nine (19.5%) of 46 patients without recurrence (not significant). Conclusion:In women with cervical cancer, HPV DNA screening of sentinel nodes might help to identify patients at risk of lymph node metastases and recurrence.

show abstract

Section: Patients and Methods Patientsmentioning

confidence: 99%

“…The sentinel lymph node (SN) procedure has emerged as a less aggressive alternative [7,9,10]. Moreover, serial sectioning and immunohistochemical analysis of SN can detect micrometastasis [7,9,10].…”

mentioning

confidence: 99%

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Coutant¹,

Barranger²,

Cortez

et al. 2007

Annals of Oncology

View full text Add to dashboard Cite

show abstract

“…In addition, the method of detection varied from study to study, with some investigators using only blue dye injection, 5,13,15 some using only radioisotope injection, 11,16 and some using a combination of these two methods. 10,12,14,17,18 Our preliminary study 5 indicated that SLN biopsy was reliable in predicting the status of the pelvic lymph nodes, with a negative predictive value of 100% for pelvic SLNs and NSLNs when classical pathologic evaluation techniques were used. Our experience with the assessment of this technique subsequently expanded, with more than 100 patients eventually being evaluated; the observed negative predictive value remained at 100%.…”

Section: Discussionmentioning

confidence: 94%

Sentinel lymph node biopsy is not accurate in predicting lymph node status for patients with cervical carcinoma

Marchiolè

Buénerd

Scoazec

et al. 2004

Cancer

View full text Add to dashboard Cite

BACKGROUNDThe authors evaluated the accuracy of sentinel lymph node biopsy in predicting lymph node status for patients with early cervical carcinoma. In particular, the authors set out to determine the false‐negative rate associated with sentinel lymph node biopsy in this setting.METHODSTwenty‐nine consecutive patients with early cervical carcinoma who were treated with pelvic laparoscopic lymphadenectomy and radical surgery underwent sentinel lymph node biopsy following lymphatic mapping with patent blue dye. All sentinel and nonsentinel lymph nodes were evaluated for micrometastases via multilevel sectioning followed by immunohistochemical staining.RESULTSAt least one sentinel lymph node was identified for each patient. On routine pathologic evaluation, 3 patients (10%) were found to have positive lymph nodes. Among the remaining 26 patients, multilevel sectioning in conjunction with immunohistochemical analysis identified 5 patients (19%) who had micrometastases in the pelvic lymph nodes. Two of these five patients had micrometastases in a sentinel lymph node; however, the more notable finding was that the other three patients had micrometastases in nonsentinel pelvic lymph nodes despite having negative findings on sentinel lymph node biopsy. Thus, the negative predictive value of sentinel lymph node biopsy in the current study was 87.5%.CONCLUSIONSMultilevel sectioning followed by cytokeratin immunohistochemistry may identify additional patients who have lymph node micrometastases; in the current study, this technique identified cases in which micrometastases were present in nonsentinel lymph nodes even when sentinel lymph nodes were found to be negative for disease on biopsy. This high false‐negative rate associated with sentinel lymph node biopsy, raises questions regarding the validity of the sentinel lymph node concept in cervical carcinoma. Cancer 2004. © 2004 American Cancer Society.

show abstract

“…In a study of 50 patients with cervical cancer of FIGO stages I-IV by Malur et al, a combination of radioactively labeled albumin and blue dye yielded an SLN detection rate of 78 %. [11] Barranger et al emphasised in several publications that in cervical cancer, regional lymph node status is a major prognostic factor and a criterion for the use of adjuvant therapy [16]. They asserted that the SLN procedure based on blue dye and radiocolloid is suitable for evaluation of lymph node status.…”

Section: Discussionmentioning

confidence: 99%

Role of Sentinel Lymph Node Biopsy in Early Cervical Cancer

Somashekhar

Naikoo

Zaveri

et al. 2012

Indian J Surg Oncol

View full text Add to dashboard Cite

Laparoscopic sentinel lymph node procedure using a combination of patent blue and radioisotope in women with cervical carcinoma

Abstract: The results of this study suggest that SN detection with a combination of radiocolloid and patent blue is feasible in patients with cervical carcinoma. The combination of laparoscopy and the SN procedure permitted minimally invasive management of early-stage disease.

Cited by 89 publications

References 32 publications

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Sentinel lymph node biopsy is not accurate in predicting lymph node status for patients with cervical carcinoma

Role of Sentinel Lymph Node Biopsy in Early Cervical Cancer

Contact Info

Product

Resources

About