Laparoscopic resection of gastric gastrointestinal stromal tumors (GIST) is safe and effective, irrespective of tumor size

Vogelaere, Kristel De; Loo, Ines Van; Peters, O.; Hoorens, Anne; Haentjens, Patrick; Delvaux, Georges

doi:10.1007/s00464-012-2186-7

Cited by 91 publications

(62 citation statements)

References 23 publications

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“…Although current guidelines recommend laparoscopic resection of gastric GISTs < 2.0 cm in size, 3,4 recent studies have demonstrated that even relatively large gastric GISTs ≥ 2.0 cm in size can be safely resected using the laparoscopic approach, and long-term outcomes have shown that only small number of cases recurred (0%~8%) during 36 to 75 months of follow-up period. [5][6][7][8][9][10] Laparoscopic resection of gastric GISTs facilitates substantial negative margins.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic versus surgical resection of GI stromal tumors in the upper GI tract

Joo

Park

Kim

et al. 2016

Gastrointestinal Endoscopy

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Section: Introductionmentioning

confidence: 99%

Endoscopic versus surgical resection of GI stromal tumors in the upper GI tract

Joo

Park

Kim

et al. 2016

Gastrointestinal Endoscopy

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“…2 GISTs can occur anywhere throughout the GI tract and are seen most commonly in the stomach (40–70%), followed by small intestine (20–40%), and colon and rectum (5–15%). 3 Many clinicopathological features were reported as prognostic factors for GISTs, including tumor location, 4 tumor size, mitotic index, 5 Ki-67, 6 histological types, 7 gene mutations, 8 and so on. However, only tumor size and mitotic index are the best prognostic indicators for determining the malignant potential of GISTs.…”

Section: Introductionmentioning

confidence: 99%

Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors

et al. 2016

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Systemic inflammation and immune response were associated with prognosis of tumors. However, data was limited due to the relatively low incidence of gastrointestinal stromal tumors (GISTs). The aim of the present study was to investigate the predictive value of preoperative peripheral blood cells in prognosis of GISTs.From September 2008 to July 2015, a total of 274 GIST patients in our department were enrolled in the present study. Clinicopathological features of GISTs were recorded. The association between preoperative peripheral blood cells and prognosis of GISTs were analyzed.Tumor location, tumor size, mitotic index, intratumoral necrosis, and National Institutes of Health (NIH) risk category were associated with prognosis of GISTs. High neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-white blood cell ratio (NWR), monocyte-to-white blood cell ratio (MWR) and low lymphocyte-to-white blood cell ratio (LWR) was associated with poor prognosis of GISTs (76.2% vs 83.7%, P = 0.010. 70.5% vs 98.7%, P = 0.000. 65.7% vs 96.4%, P = 0.004. 78.5% vs 82.5%, P = 0.044. 73.5% vs 97.8%, P = 0.004. 76.6% vs 83.6%, P = 0.012, respectively). However, tumor size was the only independent risk factor for prognosis according to multivariate analysis (P = 0.006). Tumor location, tumor size, mitotic index, and NIH risk category were significantly correlated with the above-mentioned parameters (all P < 0.05). The prognosis of GISTs with tumor size >5 cm, high MLR, high PLR, and high MWR was significantly lower than the remnant patients (P = 0.010).The peripheral blood routine test is convenient, reproducible, and inexpensive. High NLR, MLR, PLR, NWR, MWR, and low LWR were associated with poor prognosis of GISTs. The association between the above parameters and prognosis of GISTs may be attributed to their correlation with tumor size, mitotic index, and NIH risk category. The combination of tumor size, MLR, PLR, and MWR could further increase the predictive value of prognosis of GISTs.

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“…Lai et al [20] reported a 5-year survival rate of 100 % and a disease-free survival rate of 100 %. Likewise, De Vogelaere et al [8] reported a 100 % 5-year survival rate and a 100 % disease-free survival rate in laparoscopic resection regardless of tumor size. Tabrizian et al [9] reported comparable outcomes in their series with laparoscopic management of GISTs.…”

Section: Discussionmentioning

confidence: 99%

“…Laparoscopic procedures are currently favored given the excellent short-and long-term results [7][8][9][10][11]. A combined approach with endoscopy is a recent alternative in select cases.…”

mentioning

confidence: 99%

Long-term outcomes of combined endoscopic/laparoscopic intragastric enucleation of presumed gastric stromal tumors

et al. 2015

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Laparoscopic resection of gastric gastrointestinal stromal tumors (GIST) is safe and effective, irrespective of tumor size

Abstract: The low morbidity rates and the long-term disease-free interval of 100% observed in our cohort indicate that laparoscopic resection is safe and effective in treating gastric GISTs, even for tumors larger than 2 cm.

Cited by 91 publications

References 23 publications

Endoscopic versus surgical resection of GI stromal tumors in the upper GI tract

Endoscopic versus surgical resection of GI stromal tumors in the upper GI tract

Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors

Long-term outcomes of combined endoscopic/laparoscopic intragastric enucleation of presumed gastric stromal tumors

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