Laparoscopic resection of gastric gastrointestinal stromal tumors

Hindmarsh, Andrew; Koo, Brendan; Lewis, Michael P.; Rhodes, Michael

doi:10.1007/s00464-004-8168-7

Cited by 43 publications

(24 citation statements)

References 25 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unter Ausschluss von Einzelfalldarstellungen finden sich in der Literatur bis dato etwa 400 publizierte Fälle laparoskopisch resezierter GIST [17,18,26,27,29,30]. Da es sich hierbei nahezu ausnahmslos um GIST des Magens handelt, beziehen sich alle weiteren Aussagen primär auf Magen-GIST.…”

Section: Diskussionunclassified

“…[5]. Im Allgemeinen beträgt die publizierte durchschnittliche Größe laparoskopisch resezierter GIST des Magens 4,3 cm (1-8,5 cm), die Konversionsrate schwankt zwischen 0-31% und in nahezu 100% der Fälle werden R0-Resektionen angegeben [5,17,18,26,27,29,30]. Die perioperative Morbidität und Mortalität nach laparoskopischer Operation liegt meist unter jeweils 1% (0-9% bzw.…”

Section: Ergebnisse Laparoskopischer Verfahrenunclassified

“…0-2%) [5,26,27,30]. Bei noch kurzen Nachbeobachtungszeiten von durchschnittlich 35 Monaten (2-84 Monate) geben die meisten Autoren Rezidivraten von <5% (0-9,1%) an, wobei leider exakte Angaben zu Lokalisation und Therapie der Rezidive durchweg fehlen [5,18,26]. Sofern angegeben, treten die Rezidive ausschließlich nach Resektion von High-risk-GIST (nach Fletcher) auf (>5 cm und >5/50 HPF oder >10 cm oder >10/50 HPF), dies überwiegend innerhalb der ersten 24 Monate postoperativ und sie finden sich nahezu ausnahmslos lokoregionär-intrabdominell oder fernmetastatisch-intrahepatisch [5,17,18,30].…”

Section: Ergebnisse Laparoskopischer Verfahrenunclassified

See 2 more Smart Citations

Gastrointestinale Stromatumoren aus chirurgischer Sicht

Langer

Schüler

Becker

et al. 2008

Chirurg

View full text Add to dashboard Cite

Gastrointestinal stromal tumors (GIST) are the most frequent soft tissue tumors of the gastrointestinal tract. The demonstration of KIT expression (CD117) defined GIST as a distinct tumor entity. Despite many improvements in the medical therapy, complete tumor resection remains the standard treatment for resectable GIST and is the precondition for cure. Data concerning the role of laparoscopic surgery are sparse, but small gastric GIST (<5 cm) could be a good indication for laparoscopic procedures. In principle laparoscopic GIST resections should be performed only by interdisciplinary teams of surgeons and gastroenterologists experienced in laparoscopy, endoscopy, and oncology.

show abstract

Section: Diskussionunclassified

Section: Ergebnisse Laparoskopischer Verfahrenunclassified

See 1 more Smart Citation

Gastrointestinale Stromatumoren aus chirurgischer Sicht

Langer

Schüler

Becker

et al. 2008

Chirurg

View full text Add to dashboard Cite

show abstract

“…However, the tumor entity as such had not even been defined at the time, and the resection was performed inadvertently during laparoscopic cholecystectomy. At the beginning of the 21st century, the first case series of laparoscopically resected GIST were published [11,12,13]. They were limited to gastric GIST and most of them had no comparator group of patients who underwent open resection.…”

Section: Laparoscopy For Primary Gistmentioning

confidence: 99%

Surgery for Gastrointestinal Stromal Tumors: State of the Art of Laparoscopic Resection and Surgery for M1 Tumors

Ronellenfitsch

Hohenberger

2018

Visc Med

View full text Add to dashboard Cite

Background: The principles of surgery for primary gastrointestinal stromal tumor (GIST) are resection with clear margins without lymphadenectomy, thus enabling organ-preserving resection in many cases. Tumor rupture needs to be avoided, because it entails peritoneal sarcomatosis. Given these preconditions, there is a rationale for laparoscopic resection of primary GIST. In metastatic GIST, surgery cannot achieve cure, but constitutes an important cornerstone of treatment. Resection can be performed either for residual lesions in responding patients, for focally progressive lesions, or as palliative measure in generalized progression. Methods: Selective literature review. Results: There is ample evidence on laparoscopic resection of gastric GIST, but none from randomized trials. The studies show favorable perioperative outcomes and suggest adequate oncological results; however, a direct comparison to open resection is difficult. For surgery in M1 stages, survival outcomes are better for resection in generalized response than in focal progression. Perioperative morbidity is acceptable. Surgery in generalized progression does not prolong survival and bears relevant morbidity risks. Conclusion: Laparoscopy seems an adequate surgical approach for primary gastric GIST, as long as the surgical principles relevant for this entity are respected. For other tumor sites, there is no sufficient evidence available. In M1 stages, selected patients may benefit from surgery. Survival differences between resection at different stages probably mirror the biology of the disease rather than the effect of the timing of the operation.

show abstract

“…An open approach is usually reserved for larger tumours and when previous surgery renders a laparoscopic approach difficult [11]. Postoperative risk stratification can be useful in determining follow-up protocols and for assessing the benefit of adjuvant imatinib therapy [10].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Outcomes and Recurrence Patterns in Upper Gastrointestinal Tract Gastrointestinal Stromal Tumours (GISTs) Treated by Minimally Invasive Surgery

Photi

Igali²,

Cheong³

et al. 2014

Dig Surg

View full text Add to dashboard Cite

Background/Aims: Gastrointestinal stromal tumours are the most frequently occurring sarcoma of the gastrointestinal tract. Current treatment involves complete resection although the surgical or pathological margin required remains unclear. In this study we aimed to examine the risk of local and distant recurrence following laparoscopic resection. Methods: From a prospective tumour database, we identified and risk stratified primary non-metastatic tumours treated by laparoscopic resection from 2002-2012. Local technique involves allowing a 1 cm margin for resection. We then identified all cases of tumour recurrence and tumour related death in order to calculate overall survival, freedom from GIST recurrence and disease-specific survival respectively. Results: 90 patients were identified with a median follow-up of 3.9 years (range 1 week to 12.3 years). Five-year freedom from GIST recurrence and disease-specific survival rates in the high-risk group stood at 0.63 and 0.90. In the moderate-risk group these figures stood at 0.61 and 0.80 respectively. The low- and very-low-risk groups had a 10-year recurrence-free survival of 100% with no incidences of tumour-related recurrence. There were no local recurrences seen in any group at up to 10 years. Conclusion: The low recurrence rate suggests that these tumours can safely be treated laparoscopically with an R0 resection using a macroscopic surgical margin of 10 mm. Disease-specific survival was high. This may reflect earlier detection and the use of adjuvant imatinib.

show abstract

Laparoscopic resection of gastric gastrointestinal stromal tumors

Abstract: Stapled laparoscopic resection is a safe and effective treatment option for nonmetastatic primary gastric GIST.

Cited by 43 publications

References 25 publications

Gastrointestinale Stromatumoren aus chirurgischer Sicht

Gastrointestinale Stromatumoren aus chirurgischer Sicht

Surgery for Gastrointestinal Stromal Tumors: State of the Art of Laparoscopic Resection and Surgery for M1 Tumors

Long-Term Outcomes and Recurrence Patterns in Upper Gastrointestinal Tract Gastrointestinal Stromal Tumours (GISTs) Treated by Minimally Invasive Surgery

Contact Info

Product

Resources

About